The relationship between glycated hemoglobin A1c levels and exacerbation status in the patients with chronic obstructive pulmonary disease

Abstract

Objective This study was performed in Razi Hospital, Rasht, Iran, between March 2016 and August 2018 on a population of chronic obstructive pulmonary disease (COPD) patients (56 as COPD exacerbation group and 56 as COPD stable group). Study variables include age, sex, occupation, body mass index (BMI), cigarette consumption, duration of COPD, annual hospitalization, dyspnea, glycated hemoglobin (HbA1c), FEV1, and FEV1/FVC indices. Result The mean age of the participants was 63.92 ± 10.75 years. There was a significant difference in the hospitalization between the patients with both exacerbation and normal state of COPD (P ≤ 0.001). HbA1c in the patients with exacerbation of COPD was significantly higher than stable status (P = 0.001). Logistic regression showed that HbA1c levels and hospitalization were predictors of exacerbation of COPD. HbA1c levels were statistically significant in terms of hospitalization in patients with COPD exacerbation. There was a significant difference between the HbA1c levels and MMRC in patients with COPD. The percentage of HbA1c was associated with exacerbation of COPD and HbA1c is a good predictor of disease severity in patients with COPD. It also shows that patients with COPD exacerbation and severe COPD are at the higher risk of hyperglycemia.

Association between glycated haemoglobin and the risk of chronic obstructive pulmonary disease: A prospective cohort study in UK biobank

“…Previous studies reported the association of HbA1c level with the exacerbation of COPD, which is a severe complication associated with increased short-and long-term mortality. 7,13,51 A case-control study reported that HbA1c in COPD patients was associated with exacerbation of COPD and was significantly higher compared with those that were stable, which indicated that HbA1c is a good predictor of disease severity in patients with COPD. 7 A cohort study of 526 patients with COPD found that higher HbA1c levels were significantly associated with the risk of severe exacerbation in patients with COPD.…”

“…7,13,51 A case-control study reported that HbA1c in COPD patients was associated with exacerbation of COPD and was significantly higher compared with those that were stable, which indicated that HbA1c is a good predictor of disease severity in patients with COPD. 7 A cohort study of 526 patients with COPD found that higher HbA1c levels were significantly associated with the risk of severe exacerbation in patients with COPD. 13 However, an observational study in Greece based on 156 patients with acute exacerbations of COPD (AECOPD) reported that neither the preceding nor the present HbA1c levels exhibit a predictive value regarding short-or long-term outcomes of an AECOPD.…”

“…Previous studies found a significant inverse correlation between HbA1c and lung functions 5,6 . Furthermore, HbA1c is a good predictor of disease severity in patients with COPD 7 . However, the association between HbA1c level and COPD risk and survival remains limited.…”

“…5,6 Furthermore, HbA1c is a good predictor of disease severity in patients with COPD. 7 However, the association between HbA1c level and COPD risk and survival remains limited.…”

Ultra-processed food consumption, mediating biomarkers, and risk of chronic obstructive pulmonary disease: a prospective cohort study in the UK Biobank

“…48 Biologically, unbalanced glucose metabolism may lead to airflow obstruction and reduced lung function by causing endothelial dysfunction, thereby increasing the risk of COPD. 49,50 Furthermore, pathophysiological research has demonstrated that lipid metabolism may be involved in its pathogenesis. 51 For instance, HDL increased the expression of ABCA1 and activated the p38MAPK signaling pathway, which promoted the migration and proliferation of lipopolysaccharide-stimulated alveolar type II epithelial cells, thereby exerting a pro-inflammatory effect.…”