The relationship between gestational diabetes mellitus and interleukin 1beta gene polymorphisms in southwest of China

Abstract

Gestational diabetes mellitus (GDM) is a kind of chronic inflammatory condition with carbohydrate metabolism disorder. Interleukin-1beta (IL-1β) plays an important role in inflammatory response, but its role in GDM development remains unknown. The aim of this study was to analyze the association between Interleukin 1beta (IL1B) rs1143623 and rs16944 polymorphisms and susceptibility to GDM. In total, 300 pregnant women with GDM and 261 healthy pregnant women were included in the study. In both groups, single nucleotide polymorphism (SNP) rs1143623 and rs16944 were analyzed by using snapshot technology. IL-1β serum values were determined by ELISA. Serum IL-1β levels involvement in GDM development. According to the results, we found the association between the IL1B rs1143623 polymorphism and susceptibility to GDM. In further analysis, IL1B rs1143623 GG genotype had a higher level of total cholesterol (TCHO) and lower level of high density lipoprotein (HDL) in GDM patients compared with the CC/GC genotypes. However, there were no statistically significant difference between the GDM and healthy control groups in terms of rs16944 polymorphism. Our results indicated that rs1143623 in IL1B gene may lead to GDM in the southwest of china. However, no significant difference was found between GDM and rs16944. The rs1143623 genotype may significantly impact the fat metabolism, especially the levels of TCHO and HDL. We believe that our findings will contribute to understanding of the etiology and possible novel prognostic markers for GDM.

NLRP3 inflammasome activation in gestational diabetes mellitus placentas is associated with hydrogen sulfide synthetase deficiency

“…Cytokines of the IL-1 family critically regulate the inflammatory response by controlling several inflammation processes ( 39 , 40 ). Both IL-1β and IL-18, which are classic pro-inflammatory cytokines of the IL-1 family, participate in the initiation of IR of GDM and type 2 DM ( 17-19 ). The production of IL-1β and IL-18 is regulated by the NLRP3 inflammasome in different types of tissues and cells.…”

“…Interleukin (IL)-1β and IL-18 are important inflammatory cytokines in the initiation of maternal IR during GDM (17)(18)(19). The animal experimental study by Schulze et al (20) reported that treatment with an anti-IL-1β antibody improved glucose-tolerance of GDM mice.…”