The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

Usenova, Asel; Akhunbaev, Stalbek; Tumanbaev, Arstanbek; Lim, Evgeniya

doi:10.31557/apjcp.2023.24.2.613

Cited by 3 publications

(2 citation statements)

References 44 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study conducted with children with acute leukaemia, it was investigated whether there was a relationship between gender and being ill, but no relationship was found [48]. In our study, no relationship was found between gender and being ill ( p>0.05) (Table 1).…”

Section: Discussioncontrasting

confidence: 54%

Investigation of mitochondrial oxidative phosforylation enzymes in hematological cancers

DAG Seker,

AKMAN Serif

2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

It is known that cancerous cells are different from normal cells in their structure and functions. It is aimed to determine whether there is a change in the activities of mitochondrial oxidative phosphorylation (OXPOS) respiratory enzymes, the main energy production site of cells, in various haematological cancers and to use the obtained data for therapeutic purposes. In this study, leukocyte mitochondria were isolated from blood samples obtained from patients with non-hodgkin lymphoma (NHL), hodgkin lemphoma (HL), chronic lymphocytic leukaemia (CLL), acute myelogenic leukaemia (AML), acute lymphocytic leukaemia (ALL), chronic myeloid leukaemia (CML), multiple myeloma and myelodysplastic syndrome (MDS) and controls. The enzyme activities of oxidative phosphorylation complexes I, II and IV were measured by spectrophotometric method. Enzyme activity results were statistically evaluated according to various criteria. Enzyme activities were evaluated according to gender, chemotherapy or not and disease groups. As a result of these statistical evaluations, no correlation was found between the type of haematological cancer and gender (p>0.05). The difference in mitochondrial oxidative complex enzyme activities between patients receiving chemotherapy and those not receiving chemotherapy was insignificant (p>0.05). When the enzyme activities of the control group and all haematological cancer cells studied were compared, the difference was found to be statistically significant (p<0.05). As a result, changes in the activities of OXPOS respiratory enzymes were found in various haematological cancers. The large number of therapies that specifically target mitochondria, the altered metabolic functions and dynamics of mitochondria in cancer cells make it a target for cancer therapeutics.

show abstract

Section: Discussioncontrasting

confidence: 54%

Investigation of mitochondrial oxidative phosforylation enzymes in hematological cancers

DAG Seker,

AKMAN Serif

2023

GSC Biol. Pharm. Sci.

View full text Add to dashboard Cite

show abstract

“…A previous study conducted in Sudan has reported an association between Arg/Pro genotype and risk of both CLL and acute lymphoblastic leukemia (ALL) (45). Also, a Moroccan study has detected a protective effect of Arg/Arg and the Arg/Pro genotypes (46).…”

Section: Discussionmentioning

confidence: 98%

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemia

Ounalli,

Moumni,

Mechaal

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

BackgroundGenetic variations in TP53 gene are known to be important in chronic lymphocytic leukemia (CLL) and may cause its inactivation which is associated with an aggressive form of the disease. Single nucleotide polymorphism (rs1042522:G>C) in TP53 gene at codon 72 encodes for arginine (Arg) or proline (Pro) variant which results in amino acid substitution affecting the apoptotic potential of TP53 protein. The aim of this study was to assess the correlation between TP53 codon 72 polymorphism and risk susceptibility as well as severity of CLL among Tunisian patients.Materials and methodsA case-control study was conducted in Tunisia from February 2019 to November 2021, 160 de novo CLL patients and 160 healthy volunteers matched in age and gender were involved. DNA was extracted from peripheral blood mononuclear cells and the rs1042522 was analyzed using PCR-RFLP.ResultsPro variant was associated with higher susceptibility to CLL than Arg variant (p= 0.023). A significant association was found between Pro variant and prognostic classification of Binet stage C (p= 0.001), low hemoglobin level (p= 0.003) and low platelet count (p= 0.016).ConclusionWe suggest that Pro variant may increase the risk of developing CLL in our population and could be associated with the severity of the disease.

show abstract

Diagnostic and Prognostic Value of DNA Repair Gene XRCC1 ARG399GLN Polymorphism in Childhood Acute Lymphoblastic Leukemia: A Single-Center Egyptian Study

Hablas,

Mahmoud,

Qassem

et al. 2024

Alexandria Journal of Pediatrics

View full text Add to dashboard Cite

Background Repair pathways for DNA damage are essential for repairing various forms of DNA damage. Leukemia risk may be increased by poor DNA repair. This study was conducted to better understand the significance of XRCC1Arg399 Gln polymorphisms in acute lymphoblastic leukemia (ALL) susceptibility and prognosis. Patients and methods Twenty children with ALL participated in the pediatric trial at Tanta University. Thirty healthy controls were of the same age and sex. Complete blood counts, bone marrow aspirates, immunophenotyping, flow cytometry, and XRCC1 genotyping by PCR were performed. Results The allele Gln/Gln was found in one (3.3%) of the controls and two (10%) cases had an odds ratio of 0.13 (0.27–38.1), P=0.34. Eight (40%) patients and six controls [odds ratio of 2.66 (0.75–9.4), P=0.11], had the Arg/Gln allele. Finally, 23 (76.7%) members of the control group and 10 (50%) patients carried this allele (Arg/Arg). The genotype’s prognostic value for alleles: two (20%) of patients with the allele (Arg/Arg) were refractory. Two (25%) patients died during the induction for the allele (Arg/Gln), while four (50%) patients were refractory. Last but not least, no one experienced total remission under the allele (Gln/Gln). Conclusion The XRCC1 polymorphism is not linked to the development of ALL; nevertheless, having mutant alleles was linked to a poorer prognosis.

show abstract

The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia

Cited by 3 publications

References 44 publications

Investigation of mitochondrial oxidative phosforylation enzymes in hematological cancers

Investigation of mitochondrial oxidative phosforylation enzymes in hematological cancers

TP53 Gene 72 Arg/Pro (rs1042522) single nucleotide polymorphism increases the risk and the severity of chronic lymphocytic leukemia

Diagnostic and Prognostic Value of DNA Repair Gene XRCC1 ARG399GLN Polymorphism in Childhood Acute Lymphoblastic Leukemia: A Single-Center Egyptian Study

Contact Info

Product

Resources

About