The relationship between functional constipation and overweight/obesity in children: a systematic review and meta-analysis

Wang, G.; Zhang, Kun; Xiong, Yi; Liu, Si

doi:10.1038/s41390-023-02711-1

Cited by 3 publications

(4 citation statements)

References 58 publications

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“…However, we did not find a significant association between BMI and abnormal weight in relation to constipation, although children with abnormal body weight had a higher constipation prevalence than those without (18.4% vs. 12.9%). This finding contrasts with a previous report in adulthood, 74 and a recent meta-analysis 75 of nine studies (including one study in Asia 49 ) explored overweight/obesity was a risk factor for constipation in children residing in developed countries, but this effect was not observed in developing countries.…”

Section: Discussioncontrasting

confidence: 95%

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Djurijanto,

Lin,

et al. 2024

eClinicalMedicine

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Section: Discussioncontrasting

confidence: 95%

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Djurijanto,

Lin,

et al. 2024

eClinicalMedicine

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“…3 Furthermore, a recently published meta-analysis has confirmed the significant association between obesity and constipation in children in developed countries. 4 Interestingly, it seems that in developing countries children do not have an higher risk of having constipation if they are obese; however, the reason for this geographical difference is not yet clear. 4 Moreover, an Italian epidemiologic study that enrolled 103 obese/overweight children has shown a higher prevalence of functional dyspepsia in obese/overweight children than in the normal-weight controls (22.3% vs 6.9%, P = 0.0016).…”

mentioning

confidence: 99%

“…4 Interestingly, it seems that in developing countries children do not have an higher risk of having constipation if they are obese; however, the reason for this geographical difference is not yet clear. 4 Moreover, an Italian epidemiologic study that enrolled 103 obese/overweight children has shown a higher prevalence of functional dyspepsia in obese/overweight children than in the normal-weight controls (22.3% vs 6.9%, P = 0.0016). 5 Finally, a retrospective study that aimed to define the association between obesity and functional abdominal pain (FAP) disorders found that adolescents with FAP disorders had a significantly higher prevalence of overweight/obesity compared to controls (39.5% vs. 30%, respectively, p = 0.04).…”

mentioning

confidence: 99%

“…2,7,8 In addition, a diet rich in fats and proteins and low in vegetables, which typically increases caloric intake, inevitably has a negative effect on gastrointestinal tract motility, with consequences such as dyspepsia and constipation. 4,5 As for nutrition, even a diet rich in carbohydrates including fermentable oligos and monosaccharides and polyols, known as FODMAPs, can lead in predisposed subjects to the development of irritable bowel syndrome (IBS), which often seems to be associated with obesity. 9 Finally, it has been hypothesized that visceral fat may play a direct role in the onset of functional dyspepsia, not only due to mechanical effects, but also because it acts as a metabolically active organ, capable of producing pro-inflammatory adipokines.…”

mentioning

confidence: 99%

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Obesity in Children and Functional Gastrointestinal Disorders: Is It Time to Demonstrate the Causal Link?

Cinquetti,

Marchiotto,

Fingerle

2023

J Transl Gastroenterol

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Childhood obesity represents a current health emergency, due to the growing spread of this phenomenon and the complications associated with this condition. According to data from the World Health Organization (WHO), 18% of children aged between 5 and 19 are overweight or obese. 1 At the same time, the so-called functional gastrointestinal disorders (FGIDs) are also frequent in children and adolescents. These conditions are a broad spectrum of disorders, that manifest themselves with symptoms starting from the gastrointestinal tract, which cannot be explained by biochemical or structural abnormalities. 2 Their origin is based on the close connections between the gastrointestinal tract and the brain. 2 The brain-gut axis is the neuroanatomic substrate of this connection that allows communication from emotional and cognitive centers in the central nervous system to the peripheral centers of the gastrointestinal tract and vice versa. 2 Psychosocial factors such as psychological stress and mood disorders act on this substrate affecting sensory, motor, immune, and inflammatory functions of the digestive system At the same time, nutrition and microbiota com-Maternal and Child Department,

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Association between weight-adjusted-waist index and bowel habits

Yang,

Sun

2024

Sci Rep

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Obesity has become a global public health issue and is closely related to bowel habits. The Weight-Adjusted-Waist Index (WWI), a new indicator of obesity, provides a more accurate assessment of central obesity. This study aims to investigate the relationship between WWI and bowel habits. The 2005–2010 National Health and Nutrition Examination Survey (NHANES) dataset was used for the cross-sectional survey. Bowel habits were defined by self-report. Multiple logistic regression models were used to test the linear association of WWI with chronic diarrhea and constipation. Fitted smoothed curves and threshold effects analysis were used to characterize nonlinear relationships. Subgroup analyses and interaction tests were used to determine the heterogeneity and stability of the study. This population-based study included 14,238 adults (≥ 20 years). After adjusting for covariates, there was a significant positive association between WWI and chronic diarrhea (OR [95% CI] 1.27 [1.14, 1.41]). There was a non-linear association between WWI and chronic constipation, and we found a breakpoint of 9.77, with a positive correlation on the left side of the breakpoint and no statistical significance on the right side. Subgroup analyses and interaction tests showed stable and consistent results between WWI and bowel habits across the stratification factors. Elevated levels of WWI are associated with an increased risk of chronic diarrhea. A range of WWI < 9.77 is associated with an increased risk of chronic constipation. WWI is a stable valid indicator for assessing intestinal health in U.S. adults, and we should be mindful of the importance of maintaining good levels of body fat in our daily lives to maintain healthy bowel habits.

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The relationship between functional constipation and overweight/obesity in children: a systematic review and meta-analysis

Cited by 3 publications

References 58 publications

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis

Obesity in Children and Functional Gastrointestinal Disorders: Is It Time to Demonstrate the Causal Link?

Association between weight-adjusted-waist index and bowel habits

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