The relationship between frailty and serum alpha klotho levels in geriatric patients

Polat, Yasemin; Yalçın, Ahmet; Yazıhan, Nuray; Bahşi, Remzi; Sürmeli, Deniz Mut; Akdas, Sevginur; Aras, Sevgi

doi:10.1016/j.archger.2020.104225

Cited by 9 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A case–control study with a designated experimental group of 110 patients with histories of cardiovascular disease (CVD) showed that s-Klotho levels were significantly lower in the CVD group and inversely correlated with CRP and TNFα/IL10 [ 16 ]. Another study found that s-Klotho was inversely correlated with CRP levels in older populations (≥65 years), but the association was weak (R: −0.245; p =.022) [ 17 ]. However, these studies were performed in specific groups (either based on disease history or age) rather than in the general population, and the number of biomarkers were limited.…”

Section: Discussionmentioning

confidence: 99%

Soluble klotho as an effective biomarker to characterize inflammatory states

Chen

2022

Annals of Medicine

View full text Add to dashboard Cite

Background & Aims Soluble α-Klotho (s-Klotho) is a circulating protein with pleiotropic effects that mainly induce protective effects. Our study investigates the associations between s-Klotho and several established inflammatory biomarkers, with the aim of examining whether s-Klotho levels are representative of inflammatory states. Methods A total of 11,128 eligible participants from NHANES 2007–2016 were included in our study. Levels of four inflammatory biomarkers, uric acid (UA), C-reactive protein (CRP), white blood cell (WBC) count, and mean platelet volume (MPV), were examined for their relationship with s-Klotho levels. Sub-analyses sorted the total population by gender and into four quartiles. Linear regression models were used to evaluate the strengths of associations. Results All four inflammatory biomarkers were significantly associated with s-Klotho levels. UA, CRP, and WBC count showed an inverse association, while MPV showed a direct one. Of the four markers, UA was most strongly correlated with s-Klotho levels (β coefficient: −28.89 in unadjusted model, p <.001), and this relationship was stronger in women than in men (β coefficient of UA in men: −22.01, p <.001; in women: −31.54, p <.001). In addition, all four biomarkers manifested stronger associations with s-Klotho in higher quartiles, and the highest absolute values of β coefficients appeared in Q4 vs. Q1. Conclusion s-Klotho is significantly associated with well-recognized inflammatory biomarkers. A decrease in s-Klotho levels implies a general inflammatory status; therefore, s-Klotho serves as a potential biomarker that is inversely correlated with inflammatory conditions. Further applications in clinical practice will provide us with a better understanding of its role. Key messages Soluble α-Klotho (s-Klotho) levels are significantly associated with the inflammatory markers uric acid, C-reactive protein, white blood cell count, and mean platelet volume. S-Klotho is involved in inflammatory processes and plays a protective role. S-Klotho may serve as an inverse indicator of inflammation.

show abstract

Section: Discussionmentioning

confidence: 99%

Soluble klotho as an effective biomarker to characterize inflammatory states

Chen

2022

Annals of Medicine

View full text Add to dashboard Cite

show abstract

“…Martín-Núñez et al found that Patients with atherosclerotic vascular disease had lower blood concentrations and vascular expression of Klotho than control participants, although their inflammatory state was much greater, suggesting a negative and significant correlation between inflammatory parameters ( TNF-α , IL-6 , and IL-10 ) and Klotho 11 . In a cross-sectional analysis, it was shown that s-Klotho was weakly negatively linked with CRP levels in elderly populations (> 65 years) (R: − 0.245; p = 0.022) 28 . However, rather than studying the whole populace, these investigations were carried out in certain groups (based either on disease history or age).…”

Section: Discussionmentioning

confidence: 99%

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Wen,

Liu,

Zhang

2024

Sci Rep

View full text Add to dashboard Cite

The systemic immune-inflammation index (SII), an integrated and ground-breaking inflammatory measure, has been widely used in various fields. We aimed to assess the association between the systemic immune-inflammation index (SII) and α-Klotho (a new anti-aging biomarker). In this cross-sectional investigation, people with complete information on SII and α-Klotho from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2016 were the study's subject population. SII was calculated by platelet count × neutrophil count/lymphocyte count. The association between SII and α-Klotho was investigated using multivariable linear regression and a generalized additive model. In order to explore the non-linear connection, we employed smoothed curve fitting. Subgroup analysis were also performed. A total of 13,701 participants with an average age of 57.73 ± 10.86 years were enrolled, of whom 51.53% were female. After fully adjustment, SII was negatively associated with serum soluble α-Klotho [β(95% CI) = − 0.07 (− 0.08, − 0.05)]. Furthermore, we found L-shaped association between SII and klotho protein level, with the inflection point at 255 pg/ml. Subgroup analysis and interaction test revealed that there was no discernible dependence on gender, age, race, smoking, alcohol, diabetes and hypertension (all p for interaction > 0.05). SII level was negatively associated with serum klotho protein concentration in American adults. To verify our findings, more large-scale prospective investigations are still required.

show abstract

“…Figure 1 illustrates the regulation of bloodbased CF biomarkers with their respective pathways. Overall, the blood-based CF biomarkers were predominantly involved in amino acid metabolism (25,95,96,98,99) and inflammatory response pathways (96,97,(132)(133)(134).…”

Section: Major Pathways Of the Cf Biomarkersmentioning

confidence: 99%

Potential Blood-based Biomarkers for Cognitive Frailty: A Narrative Review

Wan Nazahar,

Siong Meng,

Abdul Majeed

et al. 2023

IJPNaCS

View full text Add to dashboard Cite

Cognitive frailty (CF), which refers to the coexistence of physical frailty and cognitive impairment, is predicted to rise as the global aged population continues to grow. As such, reliable biomarkers are needed to facilitate diagnosis. It is hypothesised that blood-based biomarkers, which are non-invasive, simple and inexpensive, may be useful for diagnosis of CF. The current narrative review was undertaken to perform a literature search of journals on blood-based biomarkers for CF published between 2016-2021 and to critically review the relevant journals. The literature search for published journals was performed using ScienceDirect and PubMed, and was facilitated by a combination of keywords which included blood biomarkers and CF. Further to the processes of screening and checking of published literature for eligibility based on inclusion and exclusion criteria, 19 articles were shortlisted and critically reviewed. Basically, tryptophan, C-reactive protein (CRP), total cholesterol and vitamin D were found to be the major blood-based biomarkers for CF as they were all reported by at least 2 studies. On average, tryptophan levels in CF group were 1.4 times lower than control. The majority of the blood-based biomarkers of CF were involved in amino acid (AA) metabolism and inflammatory response pathways. In general, blood- based biomarkers (i.e., tryptophan, CRP, total cholesterol and vitamin D) may be useful for diagnosis of CF but require further studies.

show abstract

The relationship between frailty and serum alpha klotho levels in geriatric patients

Cited by 9 publications

References 39 publications

Soluble klotho as an effective biomarker to characterize inflammatory states

Soluble klotho as an effective biomarker to characterize inflammatory states

L-shaped association of systemic immune-inflammation index (SII) with serum soluble α-Klotho in the prospective cohort study from the NHANES database

Potential Blood-based Biomarkers for Cognitive Frailty: A Narrative Review

Contact Info

Product

Resources

About