The relationship between fibrinogen to albumin ratio and severity of coronary artery disease in patients with STEMI

Karahan, Oğuz; Acet, Halit; Ertaş, Faruk; Tezcan, Orhan; Çalışkan, Ahmet; Demir, Muhammed; Kaya, Ahmet; Demirtaş, Sinan; Çevik, Mehmet Uğur; Yavuz, Celal

doi:10.1016/j.ajem.2016.03.003

Cited by 76 publications

(75 citation statements)

References 31 publications

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“…To the best of our knowledge, there has been only one published paper regarding FAR and it reported that FAR was significantly related to the SYNTAX score in predicting the severity of coronary artery disease in patients with ST-elevation myocardial infarction [ 26 ]. The use of FAR has never previously been reported in the field of cancers including breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer

et al. 2017

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PurposeElevated serum concentration of fibrinogen and decreased serum concentration of albumin have been reported to be markers of elevated systemic inflammation. We attempted to investigate the prognostic influence of preoperative fibrinogen to albumin ratio (FAR) for breast cancer.MethodsData from 793 consecutive primary breast cancer patients were retrospectively analyzed. Serum levels of fibrinogen and albumin were tested before curative surgery. Subjects were grouped into two groups according to the cutoff value determined by performing the receiver operating characteristic curve analysis: the high FAR group (FAR>7.1) and the low FAR group (FAR≤7.1). Overall survival was assessed using the Kaplan-Meier estimator. Independent prognostic significance was analyzed using the Cox proportional hazards model.ResultsThe high FAR group had a worse prognosis compared to the low FAR group (log-rank test, p<0.001). The prognostic effect of FAR was more significant than that of single markers such as fibrinogen (log-rank test, p=0.001) or albumin (log-rank test, p=0.001). The prognostic effect of FAR was prominent in the stage II/III subgroup (log-rank test, p<0.001) and luminal A-like subtype (log-rank test, p<0.001). FAR was identified as a significant independent factor on both univariate (hazard ratio [HR], 2.722; 95% confidence interval [CI], 1.659–4.468; p<0.001) and multivariate analysis (HR, 2.622; 95% CI, 1.455–4.724; p=0.001).ConclusionPreoperative FAR was a strong independent prognostic factor in breast cancer. Its prognostic effect was more prominent in the stage II/III subgroup and in the luminal A-like subtype. Therefore, preoperative FAR can be utilized as a useful prognosticator for breast cancer patients. Further studies are needed to validate its applications in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer

et al. 2017

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“…FAR, which comprises these two predictors, is an important serological marker that may provide information on both haemorheology and inflammation in patients with STEMI. It has been shown that there is a positive correlation between FAR and SYNTAX score in patients with STEMI, and FAR can be utilised as an independent marker of elevated SYNTAX score and the severity of coronary stenosis in STEMI [8]. Xiao et al (29) found that preoperative FAR was an independent prognostic factor in STEMI patients undergoing primary PCI and might improve risk stratification in patients with STEMI.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, fibrinogen-to-albumin ratio (FAR) has emerged as a feasible and valuable serological marker that may reflect haemorheological and inflammatory status. Elevated FAR concentration has been demonstrated in some cardiovascular diseases and is significantly associated with the severity of coronary stenosis in patients with STEMI (8). To the best of our knowledge, only a limited number of investigations have evaluated the relationship between inflammatory and haemorheological markers such as the CRP, albümin, fibrinogen, FAR and angiographic no-reflow.…”

Section: Introductionmentioning

confidence: 99%

Relationship between fibrinogen -to- albumin ratio and angiographic no-reflow in elderly patients with st-elevation myocardial infarction treated with primary percutaneous coronary intervention

Ekizler¹,

Tak²,

Çay³

2019

tjgeri

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Introduction: Primary percutaneous coronary intervention carries a low success rate and high procedural risk in elderly patients. No-reflow is a serious complication of primary percutaneous coronary intervention in the treatment of acute ST-elevation myocardial infarction. We evaluated whether admission fibrinogen-to-albumin ratio, which has emerged as an inflammatory and haemorheological marker for predicting adverse outcomes in some cardiovascular diseases, predicts angiographic no-reflow in elderly patients with ST-elevation myocardial infarction.Materials and Method: In total, 617 patients (78.1% men; median age, 75 (68-80years) who underwent primary percutaneous coronary intervention and were admitted within 12 hours from the onset of symptoms were classified into two groups based on the final thrombolysis in myocardial infarction flow grading. Noreflow was defined as post-percutaneous coronary intervention thrombolysis in myocardial infarction grade 0, 1 and 2, and angiographic success (normal reflow) was defined as thrombolysis in myocardial infarction grade 3.Results: Of the total, 29 (51.8%) patients were found to be frail, 22 (39.3%) were found to be prefrail, and 5 (8.9%) were found be nonfrail. Further, 34 (60.8%) patients were at the risk of malnutrition. Additionally, 38 (67.8%) patients had delirium and 8 (14%) patients died during the postoperative month 1. Although Nutritional Risk Screening 2002 scores positively correlated with first-month mortality, no correlation was found between malnutrition and delirium status. A positive correlation was found between clinical frailty scale score and delirium; however, there was no correlation between clinical frailty scale score and firstmonth mortality. Positive predictive values of malnutrition and frailty together for first-month mortality increased up to 54.5% from 17.6% and 13.6 and that of delirium increased to 80.2% from 54.5% and 72.4%, respectively.Conclusion: The incidence of angiographic no-reflow was 19.9% (n = 123). Patients with no-reflow had higher rates of diabetes and smoking, higher thrombus burden and Killip class≥2 on admission and lower baseline left ventricular ejection fraction; they also had increased white blood cell counts, C-reactive protein and fibrinogen-to-albumin ratio levels at admission than the normal flow group. In multivariate analysis, white blood cell count, smoking and fibrinogen-to-albumin ratio were independent predictors of angiographic no-reflow. ABSTRACTGiriş: Genç hastalarla karşılaştırıldığında, ileri yaş hastalarda primer perkütan koroner girişim, daha düşük başarı ve artmış prosedürel komplikasyonlarla ilişkilidir. No-reflow fenomeni, ST-yükselmeli miyokard enfarktüsü ile primer perkütan koroner girişim yapılan hastalarda karşılaşılabilecek en ciddi komplikasyonlardan biridir. Fibrinojen / albümin oranı; bazı kardiyovasküler hastalıklarda istenmeyen sonlanımları öngördüren, inflamasyon ve hemoreolojiyi yansıtan bir parametre olarak ortaya çıkmıştır. Biz bu çalışmada ST-yükselmeli miyokard enfarktüsü ile başv...

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“…The Atherosclerosis Risk in Communities Study showed that elevated levels of fibrinogen are a risk factor in CAD. Karahan et al [ 24 ] also showed serum fibrinogen level as a significant inflammatory marker for predicting the severity of CAD. Similar to these studies, plasma fibrinogen levels also demonstrated a stepwise increase from the control group to the triple-vessel group in our study.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of local carotid stiffness and inflammatory biomarkers in stable angina pectoris

Aslan¹,

Ozcan²,

Ayhan³

et al. 2017

pwki

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IntroductionArterial stiffness (AS) is a well-accepted and reliable predictor of atherosclerotic diseases. Inflammation plays an important role in the development of AS.AimTo evaluate local carotid stiffness (CS) together with fibrinogen and high-sensitivity C-reactive protein (hsCRP) levels in stable angina pectoris (SAP) patients.Material and methodsThe study consisted of 353 consecutive patients with SAP. All underwent coronary angiography (CAG) after the evaluation of local CS parameters and carotid intima-media thickness (IMT) from both common carotid arteries by a real-time echo-tracking system. Baseline inflammatory biomarkers, serum hsCRP and fibrinogen levels were measured. Based on CAG findings, the patients were classified into 4 groups: control subjects with normal coronary arteries (group 1, n = 86), single-vessel disease (group 2, n = 104), double-vessel disease (group 3, n = 95) and triple-vessel disease (group 4, n = 68).ResultsThe mean carotid pulse wave velocity (PWV) in patients with angiographically confirmed coronary artery disease (CAD) was significantly higher than that in patients with normal coronary arteries (7.82 ±1.76 vs. 6.51 ±0.85 cm/s, p = 0.001). The mean carotid IMT was detected to be significantly higher in group 4 patients compared to those in group 1 (p < 0.001) and group 2 (p = 0.001). Significant correlations were observed between both inflammatory biomarkers and the number of diseased vessels and carotid PWV. Using multi-variate analysis, carotid stiffness, carotid IMT, hsCRP and fibrinogen were independently associated with the presence and extent of CAD.ConclusionsLocal CS, carotid IMT, hsCRP and fibrinogen levels are significant predictors of atherosclerotic burden and they may facilitate the identification of high-risk patients for the early diagnosis and prompt treatment of CAD.

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The relationship between fibrinogen to albumin ratio and severity of coronary artery disease in patients with STEMI

Cited by 76 publications

References 31 publications

Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer

Prognostic Influence of Preoperative Fibrinogen to Albumin Ratio for Breast Cancer

Relationship between fibrinogen -to- albumin ratio and angiographic no-reflow in elderly patients with st-elevation myocardial infarction treated with primary percutaneous coronary intervention

Evaluation of local carotid stiffness and inflammatory biomarkers in stable angina pectoris

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