The relationship between fatigue and other clinical features of multiple sclerosis

Mills, Roger; Young, Carolyn A

doi:10.1177/1352458510392262

Cited by 87 publications

(82 citation statements)

References 62 publications

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“…Correlation studies on racial differences in the MS prevalence rates worldwide have revealed that the Caucasians appears to have a higher risk than other populations 22 . The majority of the subjects in the present study showed the RRMS clinical form as in previous reports, which have shown approximately 80% of the patients will initially present this form 11 . The sample exhibited low disability.…”

Section: Discussionsupporting

confidence: 63%

“…The meticulous process used in this study was important for identifying potential problems with the instrument content. Through assuring these equivalences, it was expected to maintain the psychometric properties of the NFI-MS/BR as properly docu mented in prior studies 5,11,12,13 . It has been recognized that for such an instrument to be clinically useful, it needs to be validated, appropriate for the disease in question, reliable and easy to interpret and filled out 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies on the NFI-MS 5,11,12 have required comparisons between the NFI-MS and sleep scales, thus suggesting that MS fatigue is probably associated with low sleep quality during the night and sleepiness during the day. These associations were not confirmed in this study.…”

Section: Discussionmentioning

confidence: 99%

“…This finding is supported by evidence that relates fatigue as a primarily physical symptom 2,12 . The physical component of fatigue has been shown in many studies as a factor that interferes with activities of daily living and has an impact on quality of life 5,11 .…”

Section: Discussionmentioning

confidence: 99%

“…This instrument provides a potential guide for MS fatigue assessment that can be used in research and clinical practice 9,10,11,12 . However, it has limited worldwide applicability, with published adaptation only for British English 5 and Dutch 13 , although it has been simply adapted into many languages for clinical trial purposes.…”

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confidence: 99%

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Validation of the Brazilian version of the neurological fatigue index for multiple sclerosis

Lopes

Lavado

Kaimen-Maciel

2016

Arq. Neuro-Psiquiatr.

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Fatigue is the most frequent and severe of symptoms causing morbidity and disability in multiple sclerosis (MS) patients. However, measuring fatigue is a difficult task. There is no clear definition; it is complex and multidimensional, and is a highly subjective symptom with many uncertainties regarding its pathophysiology. No biological or neuroimaging markers for fatigue are currently known 1 . The lack of standardization for fatigue measurement has resulted in development of several assessment instruments, but none of them is universally accepted. The Fatigue Severity Scale (FSS) 2 and Modified Fatigue Impact Scale (MFIS) 3 are the most widely used instruments for measuring MS fatigue, although limitations regarding their development and measurement properties have been reported. Moreover, they were not specifically developed for MS patients 4,5,6 . Studies using the Rasch measurement model have identified a need for certain items to be removed from the FSS [4] and MFIS [6] so that their measurements can be considered valid and reliable.In Brazil, FSS 7 and MFIS 8 have been widely used, despite the failings of their design and psychometric properties in Brazilian cross-cultural adaptation studies. These Brazilian versions did not fulfill the criteria for adequate sample size and design. Moreover, the psychometric properties of the Brazilian FSS adaptation were not assessed. Therefore, there are no Brazilian MS-specific instrument for assessing fatigue with reported methodological and psychometric properties ABstrACtThe Neurological Fatigue Index for Multiple Sclerosis (NFI-MS) is a new fatigue assessment instrument. The aim of this study was to cross-culturally adapt and assess the psychometric properties of the Brazilian version of the NFI-MS (NFI-MS/BR). Method: Two hundred and forty subjects with MS were recruited for this study. The adaptation of the NFI-MS was performed by translation and back translation methodology. In psychometric analysis was performed the administration of the questionnaires Epworth Sleep Scale, Fatigue Severity Scale, Modified Fatigue Impact Scale, Multiple Sclerosis Impact Scale-29, NFI-MS/BR and Pittsburgh Sleep Quality Index with retest of the NFI-MS/BR after 7 days. Results: Reliability was assessed (intraclass correlation coefficients between 0.77 and 0.86), and validity by testing 41 hypotheses about expected correlations between subscales and confirmed 36. The majority of correlations were demonstrated. Conclusion: The NFI-MS/BR is a cross-culturally adapted, valid, and reliable instrument for assessing MS fatigue among Brazilian subjects.Keywords: multiple sclerosis; fatigue; assessment; validation studies; psychometrics. resumo O índice neurológico de fadiga na esclerose múltipla (EM) (NFI-MS) é um novo instrumento de avaliação da fadiga. O objetivo deste estudo foi adaptar transculturalmente e avaliar as propriedades psicométricas da versão Brasileira do NFI-MS (NFI-MS/BR).Método: Duzentos e quarenta indivíduos com EM participaram deste estudo. A adaptação do NFI-MS/BR f...

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Validation of the Brazilian version of the neurological fatigue index for multiple sclerosis

Lopes

Lavado

Kaimen-Maciel

2016

Arq. Neuro-Psiquiatr.

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Unexplained Symptoms

2022

Unravelling Long COVID

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Validity and reliability of the Fatigue Severity Scale in Finnish multiple sclerosis patients

et al. 2017

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BackgroundFatigue is one of the most debilitating symptoms in multiple sclerosis (MS) considerably interfering with patients’ daily functioning. Both researchers and clinicians need psychometrically robust methods to evaluate fatigue in MS.ObjectivesThe objective of this study was (i) to evaluate the psychometric properties of the Finnish version of the Fatigue Severity Scale (FSS) and (ii) to describe the results among patients with MS.MethodsIn total, 553 patients with MS (mean age, 53.8 years; standard deviation [SD], 11.4; 79% women: mean patient‐defined disease severity, Expanded Disability Status Scale [EDSS] 4.0, SD, 2.5) completed the self‐administered questionnaires including the FSS. A standard procedure was used for the translation of the FSS.ResultsThe mean (SD) score for the FSS was 4.5 (1.7); in 65% of the patients, the score was ≥4.0. The data quality of the FSS was excellent, with 99.6% of computable scale scores. Floor and ceiling effects were minimal. The FSS showed high internal consistency (Cronbach's alpha, 0.95). Unidimensionality was supported based on confirmatory factor analysis with the comparative fit index being 0.94. The FSS showed moderate/high correlations with the perceived burden of the disease, quality of life and disease severity, whereas, age or gender did not have a significant effect on the FSS score.ConclusionsThe Finnish version of the FSS showed satisfactory reliability and validity and thus can be regarded as a feasible measure of self‐reported fatigue.

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The relationship between fatigue and other clinical features of multiple sclerosis

Abstract: Clear relationships were found between fatigue and disability, disease type and sleep. Further physiological enquiry and trials of drug treatment and sleep modulation might be guided by these clinical relationships.

Cited by 87 publications

References 62 publications

Validation of the Brazilian version of the neurological fatigue index for multiple sclerosis

Validation of the Brazilian version of the neurological fatigue index for multiple sclerosis

Unexplained Symptoms

Validity and reliability of the Fatigue Severity Scale in Finnish multiple sclerosis patients

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