Background: Family dysfunction can significantly impact the mental health of university students. Effective coping mechanisms play a crucial role in mitigating the negative impact of family dysfunction on students' mental well-being. Aim: to investigate the relationship between dysfunctional family dynamics, mental health issues, and coping strategies among Najran University students in Saudi Arabia. Methods: Cross-sectional study. Data collection methods: the researchers utilized a structured questionnaire comprising five parts: socio-demographic information, family functioning, mental health assessment, and coping strategies. A convenience sample was used to include 386 students. Results: the current study revealed that more than half of the studied families were functional. Regarding mental health risk, more than one-quarter were at high risk for mental health problems. In terms of coping mechanisms, more than one-third were unsatisfactory. Further analysis demonstrated a strong negative correlation between family functioning and the likelihood of mental health problems. Additionally, there was a moderate negative correlation between the use of coping mechanisms and the likelihood of mental health issues. Conclusion: The study underscores the crucial role of family dynamics in influencing mental health outcomes among university students. Dysfunctional family environments were associated with increased risks of mental health problems. Conversely, effective coping strategies were linked to lower mental health risks. Recommendations: Educational programs aimed at enhancing coping skills and resilience among students should also be prioritized.