The relationship between extracellular fluid and obstructive sleep apnea in non-obese patients

Metín, Mehmet; Avcu, Mustafa; Ulcay, Tufan; Yavaş, Mehmet Cihan

doi:10.1080/08869634.2021.1894858

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…A high arousal frequency was observed in patients with chronic renal failure undergoing dialysis for removing body water, which is a relatively low-effectiveness method [ 22 ]. Moreover, increased body water levels may lead to fluid accumulation in the pulmonary system or upper airways, resulting in edema and further exacerbating airway obstruction [ 23 ]. Although several mechanisms have been identified as aggravating OSA severity and triggering arousal from sleep, the associations between parameters related to body fat or water and the manifestations or risk of low-ArTH OSA remain underexplored.…”

Section: Introductionmentioning

confidence: 99%

Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution

Hsu

Yang

Tsai

et al. 2023

Life

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Obstructive sleep apnea (OSA) with a low arousal threshold (low-ArTH) phenotype can cause minor respiratory events that exacerbate sleep fragmentation. Although anthropometric features may affect the risk of low-ArTH OSA, the associations and underlying mechanisms require further investigation. This study investigated the relationships of body fat and water distribution with polysomnography parameters by using data from a sleep center database. The derived data were classified as those for low-ArTH in accordance with criteria that considered oximetry and the frequency and type fraction of respiratory events and analyzed using mean comparison and regression approaches. The low-ArTH group members (n = 1850) were significantly older and had a higher visceral fat level, body fat percentage, trunk-to-limb fat ratio, and extracellular-to-intracellular (E–I) water ratio compared with the non-OSA group members (n = 368). Significant associations of body fat percentage (odds ratio [OR]: 1.58, 95% confident interval [CI]: 1.08 to 2.3, p < 0.05), trunk-to-limb fat ratio (OR: 1.22, 95% CI: 1.04 to 1.43, p < 0.05), and E–I water ratio (OR: 1.32, 95% CI: 1.08 to 1.62, p < 0.01) with the risk of low-ArTH OSA were noted after adjustments for sex, age, and body mass index. These observations suggest that increased truncal adiposity and extracellular water are associated with a higher risk of low-ArTH OSA.

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Section: Introductionmentioning

confidence: 99%

Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution

Hsu

Yang

Tsai

et al. 2023

Life

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Phase angle (PhA) in overweight and obesity: evidence of applicability from diagnosis to weight changes in obesity treatment

Cancello

Brunani

Brenna

et al. 2022

Rev Endocr Metab Disord

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Phase angle (PhA) is a recently proposed marker of nutritional status in many clinical conditions. Its use in patients with obesity presents different critical concerns due to the higher variability of the two measured parameters (resistance, R, and reactance, Xc) that contribute to the determination of PhA. Controversial is the relation between PhA and BMI that might vary with graded levels of obesity due to the variation in fat and free fat mass. Obesity is frequently associated with metabolic, hepatic, cardiovascular and kidney diseases that introduce variations in PhA values, in relation to multimorbidity and severity degree of these diseases. It is reported that the improvement of clinical condition is associated with a positive change in PhA. Also, the treatment of obesity with weight loss might confirm this effect, but with different responses in relation to the type and duration of the intervention applied. In fact, the effect appears not only related to the percentage of weight loss but also the possible loss of free fat mass and the nutritional, metabolic and structural modifications that might follow each therapeutic approach to decrease body weight. We can conclude that the PhA could be used as marker of health status in patients with obesity supporting an appropriate weight loss intervention to monitor efficacy and fat free mass preservation.

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Progress in Obstructive Sleep Apnea Syndrome in Non-Obese Patients

胡热西坦木¹

2023

ACM

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The relationship between extracellular fluid and obstructive sleep apnea in non-obese patients

Cited by 3 publications

References 18 publications

Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution

Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution

Phase angle (PhA) in overweight and obesity: evidence of applicability from diagnosis to weight changes in obesity treatment

Progress in Obstructive Sleep Apnea Syndrome in Non-Obese Patients

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