The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder

Xie, Linghua; Hu, Yuhan; Yan, Dandan; McQuillan, Patrick; Liu, Yue; Zhu, Shengmei; Zhu, Zhili; Jiang, You-Ming; Hu, Zhiyong

doi:10.1016/j.phrs.2021.105440

Cited by 3 publications

(4 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study, we found that repeated sevoflurane exposure at neonates can lead to impulsive behavior in adulthood ( Xie et al, 2020 ). Moreover, research shows that general anesthesia can lead to hyperactivity behaviors ( Xie et al, 2021 ). It is true that the synaptogenesis in 7-day-old rats is extremely sensitive to external factors, and the toxic effects from anesthetic agents can cause brain functional abnormalities that persist into adulthood.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety–Free, and Enhancement of Memory Consolidation in Mice

Wang

Cao

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

BackgroundSevoflurane exposure at brain developmental stages has been reported to induce neurotoxicity and, subsequently, results in learning deficits at the juvenile age. In this study, we aimed to investigate the effects of prior early-age sevoflurane exposure on locomotor activity, anxiety, CA1-dependent learning, and spatial memory, as well as synapse changes in mice.MethodsTotally, 3% sevoflurane was given to neonatal mice at postnatal day 7 for 4 h. These sevoflurane-treated mice were later subjected to open field and Morris water maze tests at their adult age (postnatal days 60–90) to assess their motor activity and spatial learning ability, respectively. The brain slices of sevoflurane-treated and control mice were examined for dendritic spine density and long-term potentiation (LTP) features following behavior tests (postnatal day 60). Protein levels of N-methyl-D-aspartate (NMDA) receptor subtypes and PSD95 in brain lysate were measured by using immunoblotting at the same age (postnatal day 60).ResultsPrior early-age sevoflurane exposure increased the overall moving distance, prolonged the central-area lingering time, and increased the central-area entries of adult mice. Sevoflurane-treated mice spent more time in the target quadrant during the probe test. An increase of the spine density of pyramidal neurons in the CA1 region was observed in sevoflurane-treated mice. NMDA receptor GluN2A subunit, but not the GluN2B or PSD95, was increased in the brain lysate of sevoflurane-treated mice compared with that of control mice. LTP in the hippocampus did not significantly differ between sevoflurane-treated and control mice.ConclusionExposure to sevoflurane for mice during an early brain developmental stage (P7) induces later-on hyperactivity, anxiety-free, and enhancement of memory retention. These observations shed light on future investigations on the underlying mechanisms of sevoflurane’s effect on neuronal development.

show abstract

Section: Discussionmentioning

confidence: 99%

Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety–Free, and Enhancement of Memory Consolidation in Mice

Wang

Cao

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Exposure to general anaesthetic agents (GAAs), such as sevoflurane, propofol, and ketamine, elevated the risk of developing impulse control disorders, as demonstrated in several clinical research [23]. This could happen throughout a lifetimeduring childhood, repeated exposure to GAAS elevated the frequency of attention deficit hyperactivity disorder (ADHD); an anesthesiologist, influenced by long-term exposure to sevoflurane out of occupational need, developed impulsive sevoflurane-seeking behavior [24]. It is suggested that aesthetics might induce the inflammatory activation of microglia, which is characterised by upregulated cytokine profiles and microglia-mediated neuronal synaptic changes.…”

Section: Substance Use Disorder(alcohol/drug Use Disorder)mentioning

confidence: 99%

“…Hippocampus, a seahorse-like structure embedded deep into the temporal lobe, is responsible for learning, memory, and spatial navigation. Besides, it could regulate motivational and behavioral control as hippocampal lesions, or injuries could lead to impulse control disorders [23]. Although it is less discussed as a neural substrate of impulsivity, recent evidence has further proven that hypothalamus-hippocampus circuity can regulate impulsivity via melanin-concentrating hormone [47].…”

Section: Hippocampusmentioning

confidence: 99%

“…This adds up to the difficulty and complexity of proving the neuroinflammation-driven impulsivity claim, especially in clinical evidence, as its reverse causality can fully explain the association between neuroinflammation and impulsivity [89]. This caveat is apparent, especially in substance use disorders (SUD): high impulsivity leads to abused consumption of alcohol, drugs, or high-fat foods, which serve as neuroinflammatory stimuli themselves [23]. This makes it nearly impossible to examine the neuroinflammation-driven impulsivity link in the above clinical contexts, even if participants are asked to abstained from the inflammatory stimuli for several days before the study visitsthe effects of a lifetime of impulsive behaviors (e.g.…”

Section: The Bidirectionality Of the Neuroinflammation-impulsivity Linkmentioning

confidence: 99%

See 1 more Smart Citation

The crosstalk between the “inflamed” mind and the “impulsive” mind: activation of microglia and impulse control disorders

Luo

2023

Second International Conference on Biological Engineering and Medical Science (ICBioMed 2022)

View full text Add to dashboard Cite

Impulse control disorder(ICD) is a psychiatric disease characterized by impulsivity, the tendency to act without enough thinking and the incapability to resist urges. The consequences of ICD are widespread, which not only hamper the normal life of individuals but also cause heavy burdens to society. Existing ICD treatment focuses on psychological therapies and neurotransmission-oriented pharmaceuticals, but the efficacy is not satisfactory, necessitating the exploration of a new therapeutic direction. It was not until recently that neuroinflammation was revealed to be associated with ICD. Persistent activation of microglia, one of the typical characteristics of neuroinflammation, has been reported widely in impulsivity studies in human and animal models. Hence, this review has summarized clinical and pre-clinical evidence of microglial participation in ICD, and elucidated the mechanisms underlying the neuroinflammation-ICD relationship, focusing on cytokines and their impacts on neurotransmitters, neural substrates, and neurocircuits. The results: (1) recognize limitations of existing correlational evidence in supporting the causal claims; (2) propose areas for future clinical and experimental studies to determine the causal and mechanistic relationship between neuroinflammation and the development of impulsivity; (3) provide a possible novel direction, anti-neuroinflammation, for ICD treatment. In conclusion, microglia activation is closely associated with ICD, and anti-neuroinflammation might be the next therapeutic target for ICD treatment.

show abstract

Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities

Li,

Guan,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder

Cited by 3 publications

References 144 publications

Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety–Free, and Enhancement of Memory Consolidation in Mice

Sevoflurane Exposure in the Developing Brain Induces Hyperactivity, Anxiety–Free, and Enhancement of Memory Consolidation in Mice

The crosstalk between the “inflamed” mind and the “impulsive” mind: activation of microglia and impulse control disorders

Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities

Contact Info

Product

Resources

About