“…Compelling data suggest that DNP-mediated effects are dose-dependent [ 289 ]. This means that when used at high concentrations, DNP can evoke serious side effects, such as agranulocytosis, hyperthermia, skin reactions, and cataracts; in contrast, when used at low concentrations, it induces mild mitochondrial uncoupling that is beneficial in terms of reducing oxidative neuronal damage in different pathological conditions, including AD [ 290 , 291 ]. The first evidence came from the group of De Felice, who observed that DNP, at low concentrations, protected neurons against Aβ toxicity [ 292 ] and promoted neuritogenesis and neuronal differentiation in cortical and hippocampal neuronal cultures [ 293 ].…”