2022
DOI: 10.1007/s11010-022-04624-9
|View full text |Cite
|
Sign up to set email alerts
|

The relationship between experimental 2,4-Dinitrophenol administration and neurological oxidative stress: in terms of dose, time and gender differences

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 3 publications
(1 citation statement)
references
References 37 publications
0
1
0
Order By: Relevance
“…Compelling data suggest that DNP-mediated effects are dose-dependent [ 289 ]. This means that when used at high concentrations, DNP can evoke serious side effects, such as agranulocytosis, hyperthermia, skin reactions, and cataracts; in contrast, when used at low concentrations, it induces mild mitochondrial uncoupling that is beneficial in terms of reducing oxidative neuronal damage in different pathological conditions, including AD [ 290 , 291 ]. The first evidence came from the group of De Felice, who observed that DNP, at low concentrations, protected neurons against Aβ toxicity [ 292 ] and promoted neuritogenesis and neuronal differentiation in cortical and hippocampal neuronal cultures [ 293 ].…”
Section: Mitochondria-based Therapies For Alzheimer’s Diseasementioning
confidence: 99%
“…Compelling data suggest that DNP-mediated effects are dose-dependent [ 289 ]. This means that when used at high concentrations, DNP can evoke serious side effects, such as agranulocytosis, hyperthermia, skin reactions, and cataracts; in contrast, when used at low concentrations, it induces mild mitochondrial uncoupling that is beneficial in terms of reducing oxidative neuronal damage in different pathological conditions, including AD [ 290 , 291 ]. The first evidence came from the group of De Felice, who observed that DNP, at low concentrations, protected neurons against Aβ toxicity [ 292 ] and promoted neuritogenesis and neuronal differentiation in cortical and hippocampal neuronal cultures [ 293 ].…”
Section: Mitochondria-based Therapies For Alzheimer’s Diseasementioning
confidence: 99%