The Relationship between Epigenetic Age and Myocardial Infarction/Acute Coronary Syndrome in a Population-Based Nested Case-Control Study

Malyutina, Sofia; Chervova, Olga; Tillmann, Taavi; Максимов, В. Н.; Ryabikov, A.; Гафаров, В. В.; Hubacek, Jaroslav A.; Pikhart, Hynek; Beck, Stephan; Bobák, Martin

doi:10.3390/jpm12010110

Cited by 8 publications

(4 citation statements)

References 46 publications

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“…In this work, there was significant difference as regard to age in individuals with ACS and the control group (p<0.001). The results were in line with earlier research performed by Özalp et al [10] and Malyutina S et al [11] .…”

Section: Discussionsupporting

confidence: 93%

Soluble triggering receptor expressed on myeloid cells like transcript-1 (sTLT-1) levels in patients with acute coronary syndrome

Moneam,

Khalil,

Mohsein

et al. 2024

Int. J. Clin. Diagn. Pathol.

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Background: Acute coronary syndrome (ACS) is a primary ethology for high morbidity and mortality rates worldwide. Soluble Triggering Receptor Expressed on Myeloid cells like transcript-1 (sTLT-1) is a membrane-bound soluble protein released by α-granules. This work was aimed assessing the (sTLT-1) levels among various ACS types with further evaluation of its correlation with other clinical & laboratory parameters. Methods: Sixty newly diagnosed ST segment elevation myocardial infarctions (STEMI), NSTEMI and unstable angina (UA) patients were involved in our research. In addition, twenty healthy individuals served as control. Participants went through a categorization into the following groups: The first group includes sixty patients suffering from ACS which is subdivided into three equal subgroups: a) STEMI, b) NSTEMI and c) UA. The second group includes twenty healthy individuals (control group). Results:The main important finding in the present work was significantly increase in sTLT-1 levels in ACS group compared to control group (p<0.001). A positive relationship between sTLT-1 and triglyceride (r=0.349, p=0.006), low density lipoprotein (LDL) (R=0.270, P=0.037) and neutrophil to lymphocyte ratio (NLR) (r=0.259, p=0.046) was documented. A negative relationship between sTLT-1 and HDL (r= -0.262, p=0.043) was documented. No significant association between sTLT-1 and fasting blood glucose (FBG), post prandial blood glucose (PPFBG), age, glycated hemoglobin (HbA1C), cholesterol, hemoglobin (HB), hematocrit, white blood cell (WBCs), creatine kinase-myoglobin binding (CK MB), troponin, platelets count and body mass index (BMI). Conclusions: ACS is associated with increased level of sTLT-1 suggesting that sTLT-1 could be a potential diagnostic marker in ACS.

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Section: Discussionsupporting

confidence: 93%

Soluble triggering receptor expressed on myeloid cells like transcript-1 (sTLT-1) levels in patients with acute coronary syndrome

Moneam,

Khalil,

Mohsein

et al. 2024

Int. J. Clin. Diagn. Pathol.

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“…Basically, we used the Russian population cohort of the HAPIEE Study (Novosibirsk), which was established in 2003-2005 and followed up longitudinally, to investigate the association between biomarkers of ageing (DNAm, leukocyte telomere length, and mitochondrial DNA copy number) and risks for a number of age-related outcomes. The findings obtained previously are reported elsewhere [46][47][48][49][50][51].…”

Section: Introductionsupporting

confidence: 65%

Blood-Based Epigenetic Age Acceleration and Incident Colorectal Cancer Risk: Findings from a Population-Based Case–Control Study

Malyutina,

Chervova,

Maximov

et al. 2024

IJMS

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This study investigates the association between epigenetic age acceleration (EAA) derived from DNA methylation and the risk of incident colorectal cancer (CRC). We utilized data from a random population sample of 9,360 individuals (men and women, aged 45-69) from the HAPIEE Study who had been followed up for 16 years. A nested case–control design yielded 35 incident CRC cases and 354 matched controls. Six baseline epigenetic age (EA) measures (Horvath, Hannum, PhenoAge, Skin and Blood (SB), BLUP, and Elastic Net (EN)) were calculated along with their respective EAAs. After adjustment, the odds ratios (ORs) for CRC risk per decile increase in EAA ranged from 1.20 (95% CI: 1.04-1.39) to 1.44 (95% CI: 1.21-1.76) for the Horvath, Hannum, PhenoAge, and BLUP measures. Conversely, the SB and EN EAA measures showed borderline inverse associations with ORs of 0.86-0.87 (95% CI: 0.76-0.99). Tertile analysis reinforced a positive association between CRC risk and four EAA measures (Horvath, Hannum, PhenoAge, and BLUP) and a modest inverse relationship with EN EAA. Our findings from a prospective population-based-case-control study indicate a direct association between incident CRC and four markers of accelerated baseline epigenetic age. In contrast, two markers showed a negative association or no association. These results warrant further exploration in larger cohorts and may have implications for CRC risk assessment and prevention.

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“…Using a population cohort established in Novosibirsk in the frame of the HAPIEE study (Health, Alcohol and Psychosocial Factors in Eastern Europe) in 2003–2005 with longitudinal follow-up, we expanded the study to investigate the association between biomarkers of ageing (DNA methylation, leukocyte telomere length, and mitochondrial DNA copy number) and the risk of a number of age-related outcomes. The results obtained so far have been reported elsewhere [ 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 70%

The Relationship between All-Cause Natural Mortality and Copy Number of Mitochondrial DNA in a 15-Year Follow-Up Study

Malyutina

Максимов

Chervova

et al. 2023

IJMS

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We explored the relationship between the copy number of mitochondrial DNA (mtDNA-CN) and all-cause natural mortality. We examined a random population sample in 2003/2005 (n = 9360, men/women, 45–69, the HAPIEE project) and followed up for 15 years. Using a nested case–control design, we selected non-external deaths among those free from baseline cardiovascular diseases (CVD) and cancer (n = 371), and a sex- and age-stratified control (n = 785). The odds ratios (ORs) of death were 1.06 (95%CI 1.01–1.11) per one-decile decrease in mtDNA-CN independent of age, sex, metabolic factors, smoking, alcohol intake and education. The age–sex-adjusted ORs of death in the second and first tertiles of mtDNA-CN vs. the top tertile were 2.35 (95% CI 1.70–3.26) and 1.59 (1.16–2.17); an increased risk was confined to the second tertile after controlling for smoking and metabolic factors. The multivariable-adjusted OR of CVD death was 1.92 (95% CI 1.18–3.15) in tertile 2 vs. the top tertile of mtDNA-CN, and for cancer-related death the ORs were 3.66 (95% CI 2.21–6.05) and 2.29 (95% CI 1.43–3.68) in tertiles 2 and 1 vs. the top tertile. In the Siberian population cohort, the mtDNA-CN was an inverse predictor of the 15-year risk of natural mortality, due to the greatest impact of CVD and cancer-related death. The findings merit attention for exploring further the role of mtDNA in human ageing and the diversity of mortality.

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The Relationship between Epigenetic Age and Myocardial Infarction/Acute Coronary Syndrome in a Population-Based Nested Case-Control Study

Cited by 8 publications

References 46 publications

Soluble triggering receptor expressed on myeloid cells like transcript-1 (sTLT-1) levels in patients with acute coronary syndrome

Soluble triggering receptor expressed on myeloid cells like transcript-1 (sTLT-1) levels in patients with acute coronary syndrome

Blood-Based Epigenetic Age Acceleration and Incident Colorectal Cancer Risk: Findings from a Population-Based Case–Control Study

The Relationship between All-Cause Natural Mortality and Copy Number of Mitochondrial DNA in a 15-Year Follow-Up Study

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