The Relationship between Endothelial Dysfunction and Endothelial Cell Markers in Peripheral Arterial Disease

Igari, Kimihiro; Kudo, Toshifumi; Toyofuku, Takahiro; Inoue, Yasuhiro

doi:10.1371/journal.pone.0166840

Cited by 27 publications

(22 citation statements)

References 24 publications

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“…В литературе существуют противоречивые данные об уровнях NO х при различных ССЗ [7][8][9], что объясняется различными механизмами синтеза, запасания и изменения биодоступности, определяющими как повышение, так и снижение уровня NO на разных патофизиологических этапах формирования заболевания.…”

Section: Discussionunclassified

“…Среди маркеров ЭД наиболее полно описана прогностическая значимость ФфВ, который по данным ряда исследователей является предиктором сосудистого поражения, риска развития ССО у больных АГ [6], другими ССЗ [5] и сосудистых осложнений некоторых не-ССЗ, например, цирроза печени [15]. По результатам исследования ASCOT, ФфВ также оказался независимым предиктором поражения органов мишеней у больных АГ [7].…”

Section: Discussionunclassified

“…Среди больных ГБ преобладали лица с избыточной массой тела и ожирением. Частота курения, ожирения, нарушений обмена липидов в обследованной выборке совпадала с показателями в популяции [7]. Средний уровень АД у больных ГБ соответствовал 2 степени АГ и составлял 160,3±24,4 и 100,5±7,5 мм рт.ст.…”

Section: результатыunclassified

“…В основе развития ЭД лежит дисбаланс молекул, синтезируемых эндотелием, активация оксидативного и нитрозативного стресса, приводящая к повреждению рецепторного аппарата сосудистой стенки и снижению биодоступности биологически активных молекул [3,4]. Имеются данные о прогностической значимости фактора фон Виллебранда (ФфВ) у больных хронической болезнью почек [5], АГ [6,7], стабильных метаболитов нитритов и нитратов оксида азота (NO х ) у пациентов с ожирением и АГ [4], пороками сердца [8], циркулирующих эндотелиальных клеток предшественниц и других эндотелиальных маркеров у больных АГ [7,9].…”

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Prognostic significance of endothelial dysfunction markers in arterial hypertension

2018

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Aim. Assessment of prognostic significance of endothelial dysfunction markers: stable metabolites of nitric oxide (NOx), von Willebrand factor (vWF), endothelin-1 (E1), homocysteine and tissue plasminogen activator (tPA) in essential hypertension (EAH) patients not taking antihypertension therapy systematically.Material and methods. Totally, 12 EAH patients investigated (45 males, 79 females) (mean age 51,4±6,5 y. o., mean duration of AH 7,9±7,3 y.). Concentration of NOx in plasma was measured by spectrophotometry, and of vWF, homocysteine, E1 and tPA — by immune enzyme assay.Results. By the increase of SCORE risk level, there was significant increase of concentrations of NOx, E1, homocysteine and vWF in EAH patients (p<0,05), there were no changes in tPA levels (p>0,05). In 8 (8±1,1) years after baseline assessment, 115 patients were assessed second time. Of those 13 (11,3%) had cardiovascular events (CVE) and 5 (4,3%) died. By single factorial regression, the rate of CVE in EAH patients relate to homocystein level (р=0,01), NOx (р=0,001) and vWF (р=0,001). By multifactorial analysis, prognostic statistical significance is found for NOx (relative risk (RR) =3,8, р=0,006) and vWF (RR =3,5, р=0,005). In ROC-analysis there were found threshold levels of NOx (>46,6 mcM/L, AUC =0,863) and vWF (>1,68 mg/dL, AUC =0,738), the increase of which is followed by CVE development risk for the levels of NOx >46,6 mcM/L 3,8 times (sensitivity 81,9% and specificity 65,8%), vWF >1,68 mg/dL — 3,5 times (sensitivity 74,3% and specificity 62,7%). Combination of the parameters point on the risk increase up to 6,5 times (р=0,00007).Conclusion. NOx with the threshold of >46,6 mcM/L (RR =3,8) and vWF >1,68 mg/dL (RR =3,5) do show independent prognostic value for 5-year CVE risk assessment in EAH patients that can be applied as an additional method for risk stratification to estimate a group for more aggressive therapy and CVE prevention.

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Section: Discussionunclassified

Section: результатыunclassified

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Prognostic significance of endothelial dysfunction markers in arterial hypertension

2018

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“…Thus, the following formula was used: RHI = (C/D)/(A/B) × baseline correction. In this study, an RHI < 1.67 was used to de ne vascular endothelial dysfunction [18,19] Statistical analysis Data are expressed as mean ± standard deviation. Data distribution was determined using the Shapiro-Wilk test.…”

Section: Noninvasive Vascular Function Testmentioning

confidence: 99%

Low vitamin D levels are associated with vascular endothelial dysfunction in patients with type 2 diabetes: A retrospective study

Tanaka

Okada

Hajime

et al. 2020

Preprint

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Background The aim of this study was to determine the association between serum 25-hydroxyvitamin D (25(OH)D) levels and vascular endothelial function in patients with type 2 diabetes (T2D). Methods This retrospective study included 113 T2D patients who were admitted for in-hospital diabetes educational program and underwent measurements of serum 25(OH)D levels and reactive hyperemia index (RHI). The primary endpoint was the association between serum 25(OH)D levels and RHI in T2D patients. Results Serum 25(OH)D levels correlated significantly with RHI in T2D patients (r = 0.285, p = 0.002). Receiver operating characteristic (ROC) curve analysis showed that serum 25(OH)D level of 16.5 ng/mL is the optimal cut-off level for predicting vascular endothelial dysfunction (RHI < 1.67), with a sensitivity of 68.5%, specificity of 67.9%, and area under the ROC curve (AUC) of 0.668 (95% confidence interval [CI]: 0.566–0.770, p = 0.002). The mean RHI was significantly lower (1.70 ± 0.54) in patients with low 25(OH)D levels (n = 56, 25(OH)D levels < 16.5 ng/mL) than that (1.99 ± 0.58 vs.; p < 0.001) of patients with high 25(OH)D levels (n = 57, 25(OH)D level > 16.5 ng/mL). The proportion of patients with RHI < 1.67 was also higher in the low 25(OH)D group than in the high 25(OH)D group (38% vs. 18%; p < 0.001). Multivariate logistic regression analysis identified serum 25(OH)D levels < 16.5 ng/mL was associated with increased odds of RHI < 1.67 (odds ratio 4.598, 95% CI 1.961–10.783, p < 0.001). Conclusions The results demonstrated the association of serum 25(OH)D levels with endothelial function in T2D patients and identified serum 25(OH)D level of < 16.5 ng/mL as a predictor of vascular endothelial dysfunction. Serum 25(OH)D level is a potentially useful marker of vascular endothelial dysfunction in T2D patients.

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High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome

et al. 2021

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The Relationship between Endothelial Dysfunction and Endothelial Cell Markers in Peripheral Arterial Disease

Cited by 27 publications

References 24 publications

Prognostic significance of endothelial dysfunction markers in arterial hypertension

Prognostic significance of endothelial dysfunction markers in arterial hypertension

Low vitamin D levels are associated with vascular endothelial dysfunction in patients with type 2 diabetes: A retrospective study

High-sodium diet does not worsen endothelial function in female patients with postural tachycardia syndrome

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