The Relationship Between EF and Strain Permits a More Accurate Assessment of LV Systolic Function

Pedrizzetti, Gianni; Lapinskas, Tomas; Tonti, Giovanni; Stoiber, Lukas; Žaliūnas, Remigijus; Gebker, Rolf; Pieske, Burkert; Kelle, Sebastian

doi:10.1016/j.jcmg.2019.03.019

Cited by 26 publications

(31 citation statements)

References 2 publications

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“…Feature-tracking techniques enable the assessment of myocardial deformation imaging as strain. Myocardial strain is a more robust tool to detect systolic dysfunction than ejection fraction (EF), in particular in the presence of LV-hypertrophy (21,22). Use of the sphericity index (SI) has been an effort to simply assess LV shape and function.…”

Section: Introductionmentioning

confidence: 99%

Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement

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Stoiber

Nasser

et al. 2021

Front. Cardiovasc. Med.

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Aims: Aortic valve replacement (AVR) may result in reverse cardiac remodeling. We aimed to assess long-term changes in the myocardium following AVR by Cardiac Magnetic Resonance Imaging (CMR).Methods: We prospectively observed the long-term left ventricular (LV) function and structure of 27 patients with AVR [n = 19 with aortic stenosis (AS); n = 8 with aortic regurgitation (AR)] by CMR. Patients underwent CMR before, as well as 1, 5, and 10 years after AVR. We evaluated clinical parameters, LV volumes, mass, geometry, ejection fraction (EF), global myocardial longitudinal strain (MyoGLS), global myocardial circular strain (MyoGCS), hemodynamic forces (HemForces), and Late Gadolinium Enhancement (LGE).Results: The median of LVMI, EDVI, and ESVI decreased in both groups. Patients with AR had higher initial values of EDVI and ESVI and showed a more prominent initial reduction. In AS, MyoGLS improved already after 1 year and remained constant afterward, whereas, in AR no improvement of MyoGLS was found. MyoGCS remained unchanged in the AS group but deteriorated in the AR group over 10 years. Ejection fraction (EF) was higher in AS patients compared to AR 10 years post-AVR. Late gadolinium enhancement (LGE) could be found more frequently in AS patients.Conclusion: CMR was well suited to investigate myocardial changes over a 10-year follow up period in patients with aortic valve disease. Regarding the long-term functional changes following AVR, patients with AR seemed to benefit less from AVR compared to AS patients. Fibrosis was more common in AS, but this did not reflect functional evolution in these patients. Close monitoring seems indispensable to avoid irreversible structural damage of the heart and to perform AVR at an appropriate stage.

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Section: Introductionmentioning

confidence: 99%

Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement

Rank

Stoiber

Nasser

et al. 2021

Front. Cardiovasc. Med.

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“…This finding is also in alignment with previous studies, which showed that both GLS and GCS are robust to LV volume changes, especially more robust compared with LVEF. 11,18,20 Latest works support the idea that myocardial shortening is a superior parameter for myocardial contraction and function. 21 Similar to our analysis, other studies have also shown that septal contraction is 892 D. Hashemi et al primarily impaired-even though in different cardiac diseases leading to HF.…”

Section: Discussionmentioning

confidence: 99%

“…10 Strain imaging provides the opportunity to render the spatial contractility parameters (longitudinal, circumferential, and radial strain) measurable at each voxel level over the cardiac cycle, as the LVEF is limited in discriminating HF patients and both global longitudinal and circumferential strain provide the chance to assess these subjects more accurately-especially by cardiovascular magnetic resonance imaging (CMR). 11 Since HFmrEF was just introduced in 2016 by the European Society of Cardiology (ESC) guidelines, assessment of strain imaging in HFmrEF patients has been very limited.…”

Section: Introductionmentioning

confidence: 99%

Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging

et al. 2021

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Aims Although heart failure (HF) is a leading cause for hospitalization and mortality, normalized and comparable non-invasive assessment of haemodynamics and myocardial action remains limited. Moreover, myocardial deformation has not been compared between the guideline-defined HF entities. The distribution of affected and impaired segments within the contracting left ventricular (LV) myocardium have also not been compared. Therefore, we assessed myocardial function impairment by strain in patients with HF and control subjects by magnetic resonance imaging after clinically phenotyping these patients. Methods and results This prospective study conducted at two centres in Germany between 2017 and 2018 enrolled stable outpatient subjects with HF [n = 56, including HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF)] and a control cohort (n = 12). Parameters assessed included measures for external myocardial function, for example, cardiac index and myocardial deformation measurements by cardiovascular magnetic resonance imaging, left ventricular global longitudinal strain (GLS), the global circumferential strain (GCS) and the regional distribution of segment deformation within the LV myocardium, as well as basic phenotypical characteristics. Comparison of the cardiac indices at rest showed no differences neither between the HF groups nor between the control group and HF patients (one-way ANOVA P = 0.70). The analysis of the strain data revealed differences between all groups in both LV GLS (One-way ANOVA:

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“…A standard method of assessing the systolic function of the heart is, regarding its global functionquantitative assessment of the left ventricular systolic fraction, and regarding its regional function-qualitative, visual assessment of contractility of particular myocardial segments. Over the last few years, considering limitations of standard methods to assess left ventricular systolic function, a more precise method of assessment has been proposed, namely quantitative analysis of left ventricular myocardial strain [9,10]. Initially, methods of echocardiographic assessment of left ventricular myocardial strain were developed [11].…”

Section: Introductionmentioning

confidence: 99%

Left ventricular myocardial strain assessed by cardiac magnetic resonance feature tracking in patients with rheumatoid arthritis

Tański¹,

Gać

Chachaj

et al. 2021

Insights Imaging

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Purpose The aim of the study was to assess a relationship between the occurrence of rheumatoid arthritis (RA) and its selected clinical parameters, and left ventricular myocardial strain. Material and methods Fifty-six subjects were qualified for the study: 30 RA patients and 26 subjects without rheumatoid diseases. The study design included taking medical history, assessment of the disease activity using selected scales of activity, collecting samples of venous blood to assess selected laboratory parameters and the assessment of cardiac magnetic resonance (CMR). Using the feature tracking method, the following parameters of the left ventricular myocardial strain were assessed: longitudinal strain (LS), radial strain (RS) and circumferential strain (CS). Results Regarding global values, peak LS and peak CS were statistically significantly lower in RA patients than in the control group. In the whole study group, the factors independently related to low global LS peaks were as follows: occurrence of RA, occurrence of arterial hypertension, increased activity of antibodies against cyclic citrullinated peptide and increased concentration of neutrophil gelatinase-associated lipocalin. The occurrence of RA, occurrence of diabetes, tobacco smoking, higher activity of antibodies against cyclic citrullinated peptide and current use of methotrexate are the risk factors for low peak of global CS. The current use of steroids constitutes a protecting factor against low global CS peaks. Conclusion In subjects with no clinically manifested cardiac damage, RA is associated with a deteriorated left ventricular systolic function assessed by left ventricular myocardial strain measured by CMR feature tracking.

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The Relationship Between EF and Strain Permits a More Accurate Assessment of LV Systolic Function

Cited by 26 publications

References 2 publications

Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement

Assessment of 10-Year Left-Ventricular-Remodeling by CMR in Patients Following Aortic Valve Replacement

Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging

Left ventricular myocardial strain assessed by cardiac magnetic resonance feature tracking in patients with rheumatoid arthritis

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