The relationship between early post‐operative ACTH / cortisol following pituitary surgery and long‐term glucocorticoid requirement – Do ultradian rhythms matter?
Abstract:Objective
To determine whether early (4‐8h) post‐operative ACTH after trans‐sphenoidal surgery (TSS) predicts long‐term hypothalamic–pituitary–adrenal (HPA) axis function and to investigate early morning day 1 ACTH/cortisol variability using rapid sampling.
Design
Prospective observational study.
Methods
Participants undergoing TSS were included; those treated with glucocorticoids pre‐operatively received 100 mg intravenous hydrocortisone on anaesthetic induction. ACTH and cortisol were measured post‐operative… Show more
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