The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat

Abstract

Citation for published version (APA):Hodek, P., Koblihová, J., Kizek, R., Frei, E., Arlt, V. M., & . The relationship between DNA adduct formation by benzo [a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat. Environmental Toxicology and Pharmacology, 36(3), 989-996. DOI: 10.1016989-996. DOI: 10. /j.etap.2013 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. These findings indicate the stimulation effects of both compounds on BaP-induced carcinogenesis.

Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia

“…Finally, we assessed the activity of two pairs of CYPs involved in the activation of inhaled tobacco smoke toxicants, namely CYP2A6/13 and CYP1A1/1B1 (Chiang et al, 2011;Hodek et al, 2013). We first measured the metabolic activity of CYP2A6/2A13 and CYP1A1/1B1 in MucilAir™ from three donors maintained in culture for less than one month (18 and 13 days post-delivery) (Fig.…”

Effects of exposure to polycyclic aromatic hydrocarbons combined with high‐risk human papillomavirus infection on cervical intraepithelial neoplasia: A population study in Shanxi Province, China

“…35,36 Cytochrome P450 1A (CYP1A) induced by B(a)P could catalyze ultimate carcinogenic metabolite. 37 The metabolite was easy to combine with DNA to form benzo[a]pyrene-7,8-diol-9,10-epoxide-DNA (BPDE-DNA) adduct, causing DNA damages, 38 and such a combination was a prerequisite to the occurrence and progression of cancer. 36 Another potential carcinogenic mechanism of PAHs might be related to oxidative stress.…”

Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor

“…These ligands would be ingested daily and could aggravate the toxicity of BaP through the induction of metabolic enzymes [14]. In contrast, AhR antagonists, which can prevent CYP enzyme induction, have the possibility of reducing BaP adducts [15–17]. This indicates the possibility of modulating BaP toxicity by altering AhR activity.…”