The relationship between depression and frailty syndrome: a systematic review

Buigues, Cristina; Padilla-Sánchez, Celia; Garrido, Julio Fernández; Navarro-Martínez, Rut; Ruiz-Ros, Vicente; Cauli, Omar

doi:10.1080/13607863.2014.967174

Cited by 181 publications

(179 citation statements)

References 73 publications

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“…They found that a multi-domain frailty measurement based on the CGA was more useful than frailty identified by the modified PF criteria in predicting postoperative complications, although both frailty scales were predictive of mortality rate. Thus, even though the physical phenotype of frailty is less time-consuming than the CGA assessment it does not necessarily identify remediable conditions such as malnutrition and depression (Buigues et al, 2014), that can be optimized preoperatively (although both these factors are linked to frailty in a subpopulation of frail older individuals). Afilalo et al (2012) compared the ability of four frailty scales to predict postoperative complications and mortality in patients undergoing coronary artery bypass and/or valve surgery.…”

Section: Comparison Of Different Tools For Measuring Frailty Syndromementioning

confidence: 96%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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Section: Comparison Of Different Tools For Measuring Frailty Syndromementioning

confidence: 96%

Frailty syndrome and pre-operative risk evaluation: A systematic review

Buigues

Juarros-Folgado

Fernández-Garrido

et al. 2015

Archives of Gerontology and Geriatrics

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“…Frailty and psychiatric disorders, such as major depressive disorder (MDD) and generalized anxiety disorder (GAD), are thought to be distinct but highly related clinical entities . Evidence suggests that frailty and psychiatric disorders are highly comorbid . A systematic review of evidence exploring comorbidity of frailty and depression found that 4% to 16% of frail adults aged 60 years or older had major depression, with this number rising to 35% in frail older adults aged 75 years or older and in male populations .…”

mentioning

confidence: 99%

Multicomponent Frailty Assessment Tools for Older People with Psychiatric Disorders: A Systematic Review

Sutton

Gould

Coulson

et al. 2018

J American Geriatrics Society

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Objective To review evidence evaluating the use of multicomponent frailty assessment tools in assessing frailty in older adults with psychiatric disorders. Methods A systematic literature review was conducted to identify all multicomponent frailty assessment tools (ie, a tool that assesses two or more indicators of frailty). The items of each frailty assessment tool were compared with Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM‐5) diagnostic criteria for psychiatric disorders to assess construct overlap. Studies conducted in community, inpatient, and outpatient clinical settings were considered for inclusion. Participants Adults aged 60 years or older. Results A total of 5639 records were identified following the removal of duplicates, from which 95 studies were included for review. Of the 48 multicomponent frailty assessment tools identified, no tool had been developed for, or validated in, older adult populations with a psychiatric disorder. Overall, 20 of 48 frailty assessment tools contained a psychological assessment domain, with 17 of 48 tools citing the presence of depressed mood and/or anxiety as a frailty indicator. Common areas of construct overlap in frailty assessment tools and DSM‐5 diagnostic criteria included weight loss (29 of 48) and fatigue (21 of 48). Conclusions Significant construct overlap exists between the indicators of frailty as conceptualized in existing frailty assessment tools and DSM‐5 diagnostic criteria for common psychiatric disorders including major depressive episode and generalized anxiety disorder that has the potential to confound frailty assessment results. Further research is necessary to establish a reliable and valid tool to assess frailty in this population. J Am Geriatr Soc 67:1085–1095, 2019.

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“…Only recently have researchers begun to focus on the combined depressed frail phenotype as a high risk, vulnerable population of elders (Figure 1). The purpose of this paper is not to provide a standard review of the relationship between depression and frailty which has been done previously, 15,16 but rather to propose a model for the depressed frail phenotype that elucidates the nature of the association and the potential biological pathways that explain this association, thereby setting a research agenda focused on the assessment and treatment of this high risk phenotype.…”

mentioning

confidence: 99%

The Depressed Frail Phenotype: The Clinical Manifestation of Increased Biological Aging

Brown

Rutherford

Yaffe

et al. 2016

The American Journal of Geriatric Psychiatry

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Depression in later life is a severe public health problem, associated with higher rates of mortality, suicide, and dementia. Effectiveness of treatment is limited by the failure to deconstruct the heterogeneity of the illness and because diagnostic criteria, pathophysiological models, and treatment algorithms for depression are primarily based on studies of younger adults even though symptoms of the illness and physiology of the patient change with age. Thus, understanding how aging interacts with depressive illness may elucidate endophenotypes of late life depression with different clinical manifestations and underlying mechanisms that can then be targeted with more personalized approaches to treatment. This paper proposes a model for the critical confluence between depression and frailty, a high-risk morbidity and mortality syndrome of later life. This model hypothesizes that characteristics of frailty in adults with late life depression represent the clinical manifestation of greater biological aging and their presence in the context of a depressive illness exposes elders to deleterious trajectories. Potential common biological substrates that may result in the manifestation of the depressed frail phenotype including mitochondrial functioning, dopaminergic neurotransmission, and inflammatory processes and implications for the assessment and treatment of adults with late life depression are discussed. As society continues to live longer, the preservation of the quality of these added years becomes paramount, and the combined impact of depression and frailty on the preservation of this quality warrants the attention of clinical researchers and physicians.

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The relationship between depression and frailty syndrome: a systematic review

Abstract: Studies on the causal relationship between the two syndromes are clearly necessary in the future.

Cited by 181 publications

References 73 publications

Frailty syndrome and pre-operative risk evaluation: A systematic review

Frailty syndrome and pre-operative risk evaluation: A systematic review

Multicomponent Frailty Assessment Tools for Older People with Psychiatric Disorders: A Systematic Review

The Depressed Frail Phenotype: The Clinical Manifestation of Increased Biological Aging

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