The relationship between depression and overactive bladder/urinary incontinence symptoms in the clinical OAB population

Abstract

BackgroundTo investigate the relationship between depression and overactive bladder (OAB)/urinary incontinence symptoms among the clinical OAB population.MethodsPatients who were diagnosed with overactive bladder (OAB) and age-matched control subjects without OAB were enrolled. Depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS-D). OAB/incontinence symptoms were assessed using the validated questionnaires: ICIQ-UI, ICIQ-OAB, UDI-6, IIQ-7, and OAB-q.Results27.5 % of OAB patients in our study had depression (HADS ≥8), and 12 % of OAB patients had moderate to severe depression (HADS-D ≥11). OAB patients reported significantly higher HADS-D depression scores compared to age-matched controls (5.3 ± 3.9 versus 2.8 ± 3.9, p = 0.004). OAB patients with depression reported more severe incontinence symptoms (ICIQ-UI), greater bother and more impact on quality of life (UDI-6, IIQ-7) compared to OAB patients without depression (p = 0.001, 0.01, <0.001, respectively). However there were no differences in ICIQ-OAB and OAB-q. Among OAB patients, there were positive correlations between the severity of depression symptoms and OAB/incontinence symptoms (p-values <0.001 to 0.035).Conclusions27.5 % of OAB patients have depression. OAB patients with depression reported more severe urinary incontinence symptoms, greater bother and more impact on quality of life compared to those without depression. Future studies are needed to further examine the mechanistic links between depression and OAB/urinary incontinence.

Mental Health, Sleep and Physical Function in Treatment Seeking Women with Urinary Incontinence

“…In the Korean study by Lim et al, the US studies by Lai et al, and a similar Brazilian study by Melotti et al, UI severity was positively correlated with anxiety, depression, and stress measures, even when different outcome measures were used. 5–7, 23, 25 The consistency of these results improve the credibility of our findings that worsening UI severity is an important factor associated with mental health. In women reporting UI in our study, UI severity scores ranged from 1.84–9.44.…”

“…Other groups have studied mental health factors in adults seeking treatment for overactive bladder (OAB). 5–7 Together, these studies showed that OAB was associated with higher anxiety, depression, and sleep disturbance compared to controls. Again, the comparison groups in these studies were control participants without LUTS.…”

Co-Occurring Symptoms Contribute to Persistent Fatigue in Prostate Cancer

“…Not only do these two symptoms coexist, they often respond to the same treatment and exacerbate each other [17]. In addition to pain, urinary dysfunction has also been reported to be correlated with severity of depression [50]. Interestingly, treatment for depression using duloxetine, a serotonin noradrenergic uptake inhibitor, has been shown to improve urinary symptoms [51].…”

Coexisting depressive symptoms do not limit the benefits of chronic neuromodulation: A study of over 200 patients

“…It is worth noting that at baseline, those with PHQ‐8 scores ≥10 had significantly higher ICSI‐PI and OAB‐q ss scores suggesting a higher level of initial urinary bother. This is not surprising since OAB has been associated with affective symptoms, and OAB patients with depression report more severe urinary incontinence symptoms, greater bother and more impact on quality of life . Measuring the impact of neuromodulation on depressive symptoms was not the aim of this study, but depressive symptoms did decrease significantly over 6 months after neuromodulation in those with PHQ‐8 scores ≥10 at baseline.…”