“…In contrast, the Daily Hassles Score used in the present study is a continuous variable and was positively correlated with T cell apoptosis in vitro. Previous studies have shown that the Daily Hassles Score is a good predictor of the prognosis of several illnesses [22][23][24][25]. Thus our findings extend the scope of the relationship between lymphocyte apoptosis and general mental health.…”
Objectives: Recent studies have shown that apoptosis is involved in stress responses. The present study examined if stressors increase in vitro apoptosis of peripheral blood T lymphocytes in a dose-dependent manner. Methods: Daily subjective stress was quantitatively analyzed in 40 nonsmoking men with a daily hassles questionnaire. Apoptosis of T lymphocytes was measured by flowcytometry using Annexin V/PI double staining method after 0, 12, and 24 h of culture in the presence or absence of dexamethasone (DEX). Using a cross-sectional design, the current study examined the relationship between stress and in vitro apoptosis of T cells. Results: Results showed that apoptosis of T lymphocytes in vitro has a significant correlation with stress and age. Stress was positively correlated with percentage of apoptosis in T cells after 12 h of culture, irrespective of DEX treatment. Age was positively correlated with the percentage of T cell apoptosis after 0 and 12 h of coculture with DEX. Conclusions: These results indicate that age-related apoptosis and stress-related apoptosis of T cells are modulated through different mechanisms. This is the first study to show that in vitro lymphocyte apoptosis is influenced by daily stress in a dose-dependent manner.
“…In contrast, the Daily Hassles Score used in the present study is a continuous variable and was positively correlated with T cell apoptosis in vitro. Previous studies have shown that the Daily Hassles Score is a good predictor of the prognosis of several illnesses [22][23][24][25]. Thus our findings extend the scope of the relationship between lymphocyte apoptosis and general mental health.…”
Objectives: Recent studies have shown that apoptosis is involved in stress responses. The present study examined if stressors increase in vitro apoptosis of peripheral blood T lymphocytes in a dose-dependent manner. Methods: Daily subjective stress was quantitatively analyzed in 40 nonsmoking men with a daily hassles questionnaire. Apoptosis of T lymphocytes was measured by flowcytometry using Annexin V/PI double staining method after 0, 12, and 24 h of culture in the presence or absence of dexamethasone (DEX). Using a cross-sectional design, the current study examined the relationship between stress and in vitro apoptosis of T cells. Results: Results showed that apoptosis of T lymphocytes in vitro has a significant correlation with stress and age. Stress was positively correlated with percentage of apoptosis in T cells after 12 h of culture, irrespective of DEX treatment. Age was positively correlated with the percentage of T cell apoptosis after 0 and 12 h of coculture with DEX. Conclusions: These results indicate that age-related apoptosis and stress-related apoptosis of T cells are modulated through different mechanisms. This is the first study to show that in vitro lymphocyte apoptosis is influenced by daily stress in a dose-dependent manner.
“…This has been particularly the case in terms of studies exploring the relationship between stress and health behaviours (cf., O'Connor, Jones, Conner, McMillan, & Ferguson, 2008;O'Connor, Hendrickx, et al, 2009). Such approaches have ignored the burgeoning body of evidence showing that fluctuations in within-person stressful daily hassles are important in understanding stress-outcome processes and that major stressors can have a cascading effect on daily undesirable events (e.g., Affleck, Tennen, Urrows, & Higgins, 1994;Dancey, Taghavi, & Fox, 1998;Fifield et al, 2004;Kanner, Coyne, Schaefer, & Lazarus, 1981;Newman, O'Connor, & Conner, 2007;Verkuil et al, 2012;Zautra et al, 1991). An early example comes from work by Kanner et al (1981).…”
Section: Challenge #3: Need To Incorporate Personality and Lifespan Amentioning
The concept of stress has a long and perhaps foundational history in health psychology. However, it is also not without its detractors, who point out imprecise and simplistic use of the concept. Four challenges for stress research in health psychology delineate the nuanced and contextualised future. First, 'stress' can be located in the environment, in appraisal or in response (e.g., emotions or physiology). Careful conceptualisation and assessment can differentiate among these locales, as well as reveal interactions among them. Second, coping refers to the transaction between stress and the affected person. Understanding exactly why coping moderates the effects of stress is a major challenge for coping research. Third, stress happens to different people with different personalities and temperaments and at different stages of their lives. People may even be different from themselves at different life stages. These individual differences can impact all manner of stress and coping. Fourth, stress is dynamic. Minor events come and go, and major events create a cascade of changes in the individual's life. Understanding how stress, coping and health change over time within individuals (i.e., in a multi-level framework) will be a major advance for the field.
“…In addition to daily affect, there is evidence that daily stressors can increase the experience of daily physical symptoms (Dancey, Taghavi, & Fox, 1998). Non-specific physical symptoms are regularly experienced by the general population (Rief, Hessel, & Braehler, 2001), and represent a measure of current ongoing physical health below the threshold of disease (Ferguson, Cassaday, Erskind, & Delahaye, 2004).…”
Objectives: Higher conscientiousness (C) predicts better health outcomes. Recent research suggests stress may play an important role in explaining this relationship. The current study aimed to establish whether C moderates the relationship between daily hassle appraisals, daily affect and physical symptoms.Design and Methods: A daily diary design was used, where participants (N=103) completed a baseline measure of C followed by a 14-day daily diary, providing daily details of hassles (primary & secondary appraisals) experienced as well as positive and negative affect and physical symptoms.Results: Hierarchical linear modelling revealed that Total C (as well as two facets of C: Order and Industriousness) moderated the relationship between stress appraisals and positive affect. Specifically, the negative association between the daily appraisal of hassles as stressful (i.e., where perceived demands outweighed perceived resources) and positive affect was stronger for lower and average levels of C, Order and Industriousness. No significant moderated effects were found for negative affect or physical symptoms. The Order facet was found to be an important factor predicting attrition.Conclusions: The current study provided evidence that C and two of its facets can moderate the relationship between hassle appraisal and positive affect. C may exert part of its influence on health by modifying the effects of daily stressors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.