The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population

Kiyohara, Chikako; Nakanishi, Yoichi; Inutsuka, Sadaaki; Takayama, K.; Hara, N; Motohiro, Akira; Tanaka, Keitaro; Kono, Suminori; Hirohata, Tomio

doi:10.1097/00008571-199808000-00005

Cited by 76 publications

(33 citation statements)

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“…2) as well as in earlier studies (27). Different inducibility has been reported among the allelic variants of CYP1A1 (30,31). For example, CYP1A1*2A and CYP1A1*2B harboring a 3801T>C transition, resulting in a new MspI restriction endonuclease site, are associated with a highly inducible phenotype of the enzyme (32).…”

Section: Discussionmentioning

confidence: 63%

Association of Human Cytochrome P450 1A1 (CYP1A1) and Sulfotransferase 1A1 (SULT1A1) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone

Zheng

Sha

Liu

et al. 2010

Molecular Cancer Therapeutics

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Aminoflavone (AF), a clinically investigational novel anticancer agent, requires sequential metabolic activation by CYP1A1 and SULT1A1 to exert its antitumor activities. The purpose of this study was to determine the functional significance of common polymorphisms of human CYP1A1 and SULT1A1 on the metabolism and cytotoxicity of AF. To this end, Chinese Hamster V79 cells were genetically engineered to stably express human CYP1A1*1 (wild-type), CYP1A1*2C (I462V), or CYP1A1*4 (T461N) and coexpress human CYP1A1*1 with human SULT1A1*1 (wild-type), SULT1A1*2 (R213H), or SULT1A1*3 (M223V). The metabolism and cytotoxicity of AF were evaluated in these cellular models. All common variants of CYP1A1 and SULT1A1 were actively involved in the metabolic activation of AF, but with a varying degree of activity. Whereas CYP1A1 I462V variant exhibited a superior activity (mainly caused by a significantly higher V max ) for hydroxylations of AF, expression of different CYP1A1 variants did not confer cell differential sensitivity to AF. The cells coexpressing CYP1A1*1 with SULT1A1

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Section: Discussionmentioning

confidence: 63%

Association of Human Cytochrome P450 1A1 (CYP1A1) and Sulfotransferase 1A1 (SULT1A1) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone

Zheng

Sha

Liu

et al. 2010

Molecular Cancer Therapeutics

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“…This allele was also associated with increased occurrence of p53 mutations in tumor tissue (Kawajiri et al 1996;Lazarus et al 1998;Przygodzki et al 1998). In some studies, but not all, it has been associated with higher AHH inducibility (Daly et al 1998;Kiyohara et al 1998;Wedlund et al 1994).…”

Section: Pah Exposure In Humansmentioning

confidence: 99%

“…This activity is usually referred to as aryl hydrocarbon hydroxylase activity (AHH) in the lung (Anttila et al 1991). Furthermore, a positive correlation has been reported between the incidence of lung cancer and the inducibility of AHH in human lymphocytes (Gahmberg 1979;Kellerman et al 1973;Kiyohara et al 1998). Certain alleles of the human CYP1A1 gene have been implicated both in lung cancer and in prostate cancer in Japan (Hayashi et al 1992;Murata et al 1998;Rojas et al 2000), but these observations have not been reproduced in studies on Caucasian populations where the indicated alleles appear at much lower frequencies.…”

Section: Pah Exposure In Humansmentioning

confidence: 99%

Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air

Boström¹,

Gerde²,

Hanberg³

et al. 2002

Environ Health Perspect

873

459

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“…This relationship has been confirmed by several studies. [10][11][12][13][14][15] The purpose of our study was to estimate a frequency of allelic variants of CYP19, CYP1A1, CYP1A2 and SULT1A1 and their association with the elevated risk of hormonedependent cancer in the female population of the Novosibirsk region of Russia.…”

Section: Introductionmentioning

confidence: 99%

Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk

et al. 2006

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Allelic variants of cytochrome P450: CYP1A1, CYP1A2, CYP19 (Aromatase) and II-phase enzyme Sulfotransferase (SULT1A1) genes are associated with a high risk of hormone-dependent cancers. We estimated a frequency of these allelic variants in the female Caucasian population of the Novosibirsk region of Russia and their association with the elevated risk of ovarian and endometrial cancer. A DNA bank of gynecologic oncology patients, patients with benign gynecologic diseases and healthy women was created, and the following single nucleotide polymorphisms (SNPs) were examined: CYP1A1 M1 polymorphism, that is, T264-C transition in the 3 0 -noncoding region; CYP1A2*1F polymorphism, that is, C734-A transversion in CYP1A2 gene; C-T transition (Arg264Cys) in exon 7 of CYP19; SULT1A1*2 polymorphism, that is, G638-A transition (Arg213His) in SULT1A1 gene. A positive correlation of C allele of CYP1A2*1F and G allele of SULT1A1*2 with hormone-dependent cancers in women was found. Thus, these genes are appropriate candidates for studying the contribution of genetic factors to endocrine disorder and environmentally determined diseases susceptibility. In contrast, no association of CYP19 and CYP1A1 polymorphisms with increased cancer risk was revealed.

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The relationship between CYP1A1 aryl hydrocarbon hydroxylase activity and lung cancer in a Japanese population

Cited by 76 publications

References 0 publications

Association of Human Cytochrome P450 1A1 (CYP1A1) and Sulfotransferase 1A1 (SULT1A1) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone

Association of Human Cytochrome P450 1A1 (CYP1A1) and Sulfotransferase 1A1 (SULT1A1) Polymorphisms with Differential Metabolism and Cytotoxicity of Aminoflavone

Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air

Estrogen-metabolizing gene polymorphisms in the assessment of female hormone-dependent cancer risk

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