The relationship between coronary artery calcium density and optical coherence tomography-derived plaque characteristics

Okubo, Ryo; Nakanishi, Rine; Dailing, Christopher; Yabe, Takayuki; Noike, Ryota; Matsumoto, Shingo; Aikawa, Hiroto; Okamura, Y; Hashimoto, Hidenobu; Amano, Hideo; Toda, Mikihito; Maehara, Akiko; Budoff, Matthew J.; Ikeda, Takanori

doi:10.1016/j.atherosclerosis.2020.08.010

Cited by 5 publications

(15 citation statements)

References 30 publications

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“…Regarding the correlation between 18 F-FDG uptake and the calcium scores, no correlation was observed between 18 F-FDG uptake and the total AC score, ascending AC score, or CAC (Supplemental Figure 1).…”

Section: Resultsmentioning

confidence: 95%

“…The current study aimed to investigate whether the calcium score of arteries measured via thoracoabdominal plain computed tomography (CT) was associated with arterial accumulation of 18 F-fluorodeoxyglucose (FDG) on positron emission tomography (PET) /CT among patients without cancer.…”

Section: Thoracic Calcium Ann Nucl Cardiol 2022; 8 (1): 57-66mentioning

confidence: 99%

“…Between February 2015 and September 2017, 1157 patients with suspected lung cancer underwent non-contrast-enhanced chest and abdominal CT and 18 F-FDG PET examination within 6 months at our institute (Toho University Omori Medical Center, Tokyo, Japan). Among such patients, the following were sequentially excluded: patients with diagnosed lung cancer (n=926), any other malignancies (n=53), strong lymph node accumulation (n=9), and a history of thoracic or abdominal endovascular aortic repair (n=2).…”

Section: Study Populationmentioning

confidence: 99%

“…The average SUVmean value (Mean SUV) in the ascending aorta was used to calculate the target-to-background ratio (Mean TBR) [Mean SUV/(SVC-SUVmean)]. Similarly, max 18 F-FDG uptake on PET/CT using the SUV (SUVmax) was measured at the ascending aorta in every three slices (9 mm) and as bloodpool SUV at the superior vena cava (SVC) in one slice at the level of the pulmonary artery bifurcation (SVC-SUVmax). The average SUVmax value (Max SUV) in the ascending aorta was used to calculate the target-to-background ratio (Max TBR)…”

Section: Imaging Analysis Of Non-contrast-enhanced Chest and Abdomina...mentioning

confidence: 99%

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Relationship Between <sup>18</sup>F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

Okamura

Nakanishi

Hashimoto

et al. 2022

Annals of Nuclear Cardiology

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Introduction: Although 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and 18 F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of 18 F-FDG on PET. Methods: A total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and 18 F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta were used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1-399, and ≥400). The relationship between total AC scores and 18 F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis. Results: In total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1-399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p< 0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1-399 (β=0.06, 95% CI: 0.01-0.11, p=0.02) and ≥400 (β=0.11, 95% CI: 0.06-0.16, p<0.001) were significantly associated with higher Mean TBR. Conclusions: The current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by 18 F-FDG PET/CT.

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Section: Resultsmentioning

confidence: 95%

Section: Thoracic Calcium Ann Nucl Cardiol 2022; 8 (1): 57-66mentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Imaging Analysis Of Non-contrast-enhanced Chest and Abdomina...mentioning

confidence: 99%

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Relationship Between <sup>18</sup>F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

Okamura

Nakanishi

Hashimoto

et al. 2022

Annals of Nuclear Cardiology

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“…However, there is still an ongoing debate regarding the association between calci cation, plaque vulnerability, and in ammatory activity in plaque. Our group recently reported that details related to calci ed plaque (i.e., calci ed density) measured by non-contrastenhanced CT in the coronary artery were associated with optical coherence tomography (OCT)-derived calci ed size but not with OCT-derived plaque vulnerability [22]. The aforementioned study emphasized that CT-derived calcium density in local macro-calci cations may not always indicate local plaque vulnerability, although the association between calci cations and plaque activity had not been assessed.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between 18F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

Nakanishi

Hashimoto

Ota

et al. 2022

Preprint

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IntroductionAlthough 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has been widely utilized to assess the extent of inflammation, the association between the extent and severity of atherosclerosis and 18F-FDG uptake on PET remains unexamined. The current study aimed to investigate whether aortic calcium (AC) scores were associated with increased aortic uptake of 18F-FDG on PET.MethodsA total of 167 consecutive patients with suspected lung cancer but unproven malignancy who underwent non-contrast-enhanced computed tomography (CT) and 18F-FDG PET/CT were enrolled. The average standardized uptake values in the ascending aorta was used to calculate the target-to-background ratio (Mean TBR). The total (thoracic and abdominal) AC scores were measured on non-contrast-enhanced chest and abdominal CT using the Agatston method, and were categorized into three groups (0, 1–399, and ≥400). The relationship between total AC scores and 18F-FDG uptake in the ascending aorta was assessed using multivariate linear regression analysis.　ResultsIn total, 68.26% were male, and a mean age was 67.10±14.70 years. Mean TBR values increased progressively with total AC score 0, 1–399, and ≥400 (1.01±0.07, 1.08±0.09, and 1.11±0.11, respectively; p<0.00001). Multivariate linear regression analysis revealed that increased total AC scores of 1–399 (β=0.06, 95% CI: 0.01–0.11, p=0.02) and ≥400 (β=0.11, 95% CI: 0.06–0.16, p<0.001) were significantly associated with higher Mean TBR. ConclusionsThe current study demonstrated that total AC scores were associated with Mean TBR. Patients with a greater extent and severity of aortic calcifications may possess increased atherosclerotic inflammatory activity as measured by 18F-FDG PET/CT.

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The estimation of coronary artery calcium thickness by computed tomography angiography based on optical coherence tomography measurements

et al. 2023

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Optical coherence tomography (OCT) is recommended to be the most appropriate modality in assessing calcium thickness, however, it has limitations associated with infrared attenuation. Although coronary computed tomography angiography (CCTA) detects calci cation, it has low resolution and hence not recommended to measure the calcium size. The aim of this study was to devise a simple algorithm to estimate calcium thickness based on the CCTA image. MethodsConsecutive patient who had CCTA for suspected coronary artery disease and subsequently went on to have OCT were included in the study. Calcium CT density was collected from CT pro le curve. The method to estimate calcium thickness was devised from maximum CT density within the calci cation and compared to the measured calcium thickness by OCT. The accuracy of this method was compared to full width at half maximum (FWHM) or in ection point (IP) method. ResultsA total of 68-patients (238-lesions) divided into derivation and validation dataset at 2:1 ratio (47 patients with 159 lesions and 21 with 79, respectively) were analyzed. Maximum Calcium density and measured calcium-border CT density had a good correlation with a linear equation of y = 0.58x + 201 (r = 0.892, 95% CI: 0.855-0.919, p < 0.001). The estimated calcium thickness derived from this equation showed strong agreement with measured calcium thickness in validation and derivation dataset (r 2 = 0.481 and 0.527, 95% CI: 0.609-0.842 and 0.497-0.782, p < 0.001 in both, respectively), more accurate than the estimation by FWHM and IP method. ConclusionThis novel method provided the estimation of calcium thickness more accurately than conventional methods.

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The relationship between coronary artery calcium density and optical coherence tomography-derived plaque characteristics

Cited by 5 publications

References 30 publications

Relationship Between <sup>18</sup>F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

Relationship Between <sup>18</sup>F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

Relationship Between 18F-fluorodeoxyglucose Uptake on Positron Emission Tomography and Aortic Calcification

The estimation of coronary artery calcium thickness by computed tomography angiography based on optical coherence tomography measurements

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