The relationship between co-exposure to multiple heavy metals and liver damage

Chang, Zhenqi; Qiu, Jiangwei; Wang, Kai; Liu, Xiaowei; Liu, Xiuying; Zhao, Yi; Zhang, Yuhong

doi:10.1016/j.jtemb.2023.127128

Cited by 18 publications

(17 citation statements)

References 47 publications

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“…Furthermore, although trace metals such as selenium and molybdenum are essential for the human body, excessive levels of these elements can result in lung diseases [ 12 , 13 , 14 ]. Previous studies have primarily investigated the relationships between individual metal exposure and lung function; however, in real–world scenarios, humans are often exposed to multiple metals simultaneously [ 15 ]. Moreover, the interactions among these metals may amplify or diminish the toxicity or beneficial effects of individual metals [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

Chen,

Gu,

Zhou

et al. 2024

Metabolites

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Herein, we explored the overall association between metal mixtures and lung functions in populations of varying ages and the relationship among the associated components. The 2007–2012 National Health and Nutrition Examination Survey data of 4382 American participants was analyzed, and generalized linear, elastic net, quantile g–computation, and Bayesian kernel machine regression models were used to evaluate the relationship between exposure to the metal mixture and lung function at various ages. The results of barium exposure at distinct stages revealed that children and adolescents exhibited greater lung function changes than those in adults and the elderly. Additionally, compared with children and adolescents, cadmium– and arsenic–containing metabolites contributed to nonconductive lung function changes in adults and the elderly exposed to metal mixtures. The results showed that the effects of exposure to metal mixtures on lung function in children and adolescents were predominantly caused by lead and barium. Altogether, children and adolescents were found to be more susceptible to metal–exposure–mediated lung function changes than adults and the elderly.

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Section: Introductionmentioning

confidence: 99%

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

Chen,

Gu,

Zhou

et al. 2024

Metabolites

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“…Due to their chemical stability, PFAS persists in the environment, contaminating water sources and wildlife and accumulating within human bodies [ 9 , 10 ]. This persistence poses significant health concerns as PFAS can accumulate in human tissues over time, particularly in the liver [ 4 , 8 , 11 , 12 ]. Exposure to PFAS occurs through various routes, including ingestion of contaminated food and water, inhalation of airborne particles, or direct contact with PFAS-containing products [ 4 , 8 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…These metals are prevalent in various products and industries and can contaminate the environment, including water bodies and soil [ 5 , 7 , 8 ]. Like PFAS, metals persist in the environment and can accumulate in ecosystems and within human tissues over time [ 11 , 12 ]. Metals exposure occurs through pathways similar to PFAS, including ingestion, inhalation, and direct contact with contaminated materials [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The relevance of PFAS (per- and polyfluoroalkyl substances) and metals to hepatic disease is becoming increasingly significant in public health due to their rising prevalence and impact on liver health [ 11 , 12 ]. These substances, known for their persistence in the environment and potential for bioaccumulation, are implicated in various liver diseases, including non-alcoholic fatty liver disease and hepatocellular carcinoma.…”

Section: Introductionmentioning

confidence: 99%

“…These substances, known for their persistence in the environment and potential for bioaccumulation, are implicated in various liver diseases, including non-alcoholic fatty liver disease and hepatocellular carcinoma. Studies have identified a correlation between exposure to these toxic chemicals and liver dysfunction [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Combined PFOA, PFOS, Metals and Allostatic Load on Hepatic Disease Risk

Balogun,

Obeng-Gyasi

2024

JoX

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This study utilizes the National Health and Nutrition Examination Survey (NHANES) 2017–2018 data to explore the relationship between exposure to perfluoroalkyl substances (specifically perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), metals lead (Pb), mercury (Hg), and cadmium (Cd), allostatic load, and hepatic disease markers, including the fatty liver index a measure of the likelihood of non-alcoholic fatty liver disease, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin. The paper identified significant associations and interaction effects by employing descriptive statistics, Spearman’s correlation analysis, linear regression, and Bayesian kernel machine regression (BKMR). Descriptive statistics highlight sex-specific differences in contaminant levels. Spearman’s analysis underscores strong correlations among metals and per- and polyfluoroalkyl substances (PFAS). Linear regression reveals significant impacts of specific contaminants on AST, ALT, ALP, and bilirubin levels, adjusting for age and alcohol consumption. BKMR results further elucidate the complex, potentially synergistic relationships between these environmental exposures and the likelihood of non-alcoholic fatty liver disease, offering nuanced insights into their combined effects on liver health. The findings emphasize the intricate dynamics of environmental exposures on hepatic function, advocating for targeted public health interventions.

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Biosorption and Bioprotective Potential of Levilactobacillus brevis in Mice Challenged by Lead-Induced Oxidative Stress

Davtalab,

Karimi,

Moghaddam

et al. 2024

Biol Trace Elem Res

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The relationship between co-exposure to multiple heavy metals and liver damage

Cited by 18 publications

References 47 publications

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population

Association of Combined PFOA, PFOS, Metals and Allostatic Load on Hepatic Disease Risk

Biosorption and Bioprotective Potential of Levilactobacillus brevis in Mice Challenged by Lead-Induced Oxidative Stress

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