The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women

Na, Ga Yoon; Yoon, So Ra; An, Ju‐Hyun; Yeo, Rimkyo; Song, Jeong Sup; Jo, Mi-Na; Han, Seongho; Kim, Oh Yoen

doi:10.1507/endocrj.ej16-0233

Cited by 14 publications

(7 citation statements)

References 42 publications

(68 reference statements)

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“…According to previous reports, increased SFA intake in relation to TCI is associated with increased total cholesterol and low-density lipoprotein (LDL) cholesterol levels in the blood by reducing LDL receptor activities in the cells and tissues [ 17 ]; it also increases inflammatory responses by increasing lipopolysaccharide uptake in the intestine to access the blood stream easily [ 18 , 19 ]. This finding was also partly supported by the report by Na et al [ 20 ], showing that individuals that were consuming SFAs ≥ 7% of the TCI showed significantly higher levels of neutrophil gelatinase-associated lipocalin (NGAL), one of the inflammatory markers and early urinary biomarkers of tubulointerstitial injury, than those consuming SFAs < 7% of the TCI.…”

Section: Impact Of Dietary Fas On Cvd Risksupporting

confidence: 75%

Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease

Kim

Lee

2018

Nutrients

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Fatty acids (FAs) are essential nutrients and main constituents of cell membranes that are involved in the signaling pathway and associated with health conditions. We investigated if blood or erythrocyte membrane FAs can predict the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and related complications. Omega-3 (n-3) FAs are important predictors for metabolic syndrome, diabetes, CVD, and CKD risks, and the n-3 index is also a good biomarker for sudden cardiac death in coronary artery disease. Linoleic acid, which is one of the major n-6 FAs reflecting recent dietary FA intake, may predict CVD risk and mortality in the general population and patients with CKD. Monounsaturated FAs (MUFAs) are also related to diabetes or diabetic nephropathy. Oleic acid, a major MUFA, is an emerging marker that is related to acute coronary syndrome, low glomerular filtration rate, and vascular calcification in patients with CKD, and can be modified by n-3 FA supplementation. Saturated FAs, trans-FAs, and FA desaturation/elongation are associated with CVD risk; however, few studies have been conducted on patients with CKD. In summary, blood or erythrocyte membrane FA measurements are important for CVD and CKD risk prediction and management. Further studies are needed to elucidate the FAs for their risk predictions.

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Section: Impact Of Dietary Fas On Cvd Risksupporting

confidence: 75%

Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease

Kim

Lee

2018

Nutrients

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“…although different studies have associated an increase in serum lcn2 concentrations with obesity and related cardiometabolic diseases (41,42), in the present study, this adipokine was downregulated in the ovary both at 21 dpc and 30 dpn and was downregulated to a greater extent in the testicle, where the expression level of this adipokine was non-existent at 30 dpn. rees and Hay (43) observed that Lcn2 mrna expression level was decreased in the fetal liver of offspring exposed to a maternal low-protein soy oil diet compared with the relative expression observed in the fetal liver of offspring exposed to a high-protein diet.…”

Section: Discussioncontrasting

confidence: 53%

The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats

et al. 2020

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obesity represents a global health and economic burden, affecting millions of individuals worldwide. This pathology is associated with a chronic low-grade inflammatory state that is partially responsible for the development of other cardiometabolic complications. clinical studies have reported an association between high circulating levels of lipocalin-2 (lcn2) and increased body weight. additionally, there is scientific evidence demonstrating the impact of maternal obesity on fetal programming. The latter and the fact that the authors previously found that lcn2 and its receptor (24p3r) are expressed in the gonads of wild-type rats, led to the analysis of their mRNA profile and cellular localization in gonads collected from the offspring of obese rats at 21 days postconception (dpc), and 0, 2, 4, 6, 12, 20 and 30 days postnatal (dpn) in the present study. Semi-quantitative Pcr revealed a statistically significant downregulation of Lcn2 and 24p3R mrna at 21 dpc in the ovaries (P<0.01) and testicles (P<0.001) of the offspring of obese mothers. at 30 dpn, the relative expression of Lcn2 mRNA decreased significantly in the ovaries of the experimental group (P<0.05), while Lcn2 mrna expression was not detectable in testicles. regarding 24p3R, its mRNA was only significantly decreased at 21 dpc in ovaries of pups of obese mothers. at 30 dpn, the change in females was not significant. conversely, in testicles, 24p3R mrna levels increased slightly in the experimental group at 30 dpn. The lcn2 protein signal was less intense in gonadal tissue sections from 30 dpn offspring of obese rats (P<0.001), whereas the 24p3r signal was downregulated in ovaries (P<0.001) and slightly upregulated in testicles. it was concluded that maternal obesity changes the expression of lcn2 and 24p3r in the gonads of the offspring of obese rats, possibly through fetal programming. The consequences of this dysregulation for the offspring's gonadal function remains to be determined. 1 cardiovascular and Metabolic diseases research unit; 2 endocrine research unit, national Medical center,

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“…Human studies revealed that subjects with obesity had higher levels of circulating NGAL, consistent with our findings. Serum NGAL levels in high saturated fat consumers were significantly higher than those in low saturated fat consumers, even after adjusting for confounding factors [ 32 ]; in addition, an acute increase in circulating NGAL after fat overload was found in obese subjects [ 33 ]. Although the underlying mechanism for the positive correlation between NGAL and obesity remains unclear, a compensatory mechanism may be an explanation.…”

Section: Discussionmentioning

confidence: 99%

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

Pan

et al. 2018

Cardiovasc Diabetol

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BackgroundThe aim of this study was to investigate the interrelationships between three bone-derived factors [serum osteocalcin (OCN), fibroblast growth factor (FGF) 23, and neutrophil gelatinase-associated lipocalin (NGAL) levels] and body fat content and distribution, in order to reveal the potential endocrine function of bone in the development of obesity.MethodsWe recruited 1179 people (aged 59.5 ± 6.2 years) from communities in Shanghai. Serum OCN levels were determined using an electrochemiluminescence immunoassay. Serum FGF23 and NGAL levels were determined using a sandwich enzyme-linked immunosorbent assay. The abdominal fat distribution, including visceral fat area (VFA), was assessed by magnetic resonance imaging. Visceral obesity was defined as a VFA ≥ 80 cm2.ResultsSerum OCN levels were inversely correlated with body fat parameters, while FGF23 and NGAL were positively correlated (P < 0.05). After adjusting for confounders, waist circumference (W) and VFA had a closer relationship with serum OCN, FGF23, and NGAL levels than body mass index (BMI) and body fat percentage (fat%, all P < 0.05). The risk of visceral obesity significantly increased with higher FGF23 and/or NGAL levels, as well as with reduced OCN levels (all P < 0.05). In addition, serum OCN, FGF23, and NGAL levels were independently associated with visceral obesity (all P < 0.01). The relationships persisted among subjects with normal glucose tolerance or subjects with hyperglycaemia (both P < 0.05).ConclusionsCompared to the indicators of overall adiposity such as BMI or fat%, visceral adiposity indicators (W or VFA) were more closely related to serum OCN, FGF23 and NGAL levels. There was no interaction among the relationship of three bone-derived factors with visceral obesity, which revealed the independent relationship of endocrine function of skeleton with body fat.Electronic supplementary materialThe online version of this article (10.1186/s12933-018-0786-9) contains supplementary material, which is available to authorized users.

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The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women

Cited by 14 publications

References 42 publications

Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease

Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease

The gonadal expression pattern of lipocalin‑2 and 24p3 receptor is modified in the gonads of the offspring of obese rats

Correlations between serum concentration of three bone-derived factors and obesity and visceral fat accumulation in a cohort of middle aged men and women

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