The relationship between chronic pain, prehypertension, and hypertension. A population-based cross-sectional survey in Al-Kharj, Saudi Arabia

Al-Ghamdi, Sameer; Shubair, Mamdouh M.; El-Metwally, Ashraf; Alsalamah, Majid; Alshahrani, Saeed; Al-Khateeb, Badr F.; Bahkali, Salwa; Aloudah, Sara M; Al-Zahrani, Jamaan; Almigbal, Turky H.; Aldossari, Khaled K.

doi:10.1080/00325481.2020.1863716

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…Atherosclerosis is a process of deposition of fatty material in the walls of arteries, and this thickening leads to an increase in stroke and heart attack risk. Thus, although the two medications are not directly used as a cure for the condition high cholesterol, by way of atherosclerosis, high cholesterol leads to higher risk for other cardiovascular outcomes and the medications are used prevent those outcomes [16].…”

Section: Resultsmentioning

confidence: 99%

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

Wang

Benavides

Diatchenko

et al. 2022

Preprint

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Large biobank repositories of clinical conditions and medications data open opportunities to investigate the phenotypic disease network. To enable systematic investigation of entire structured phenomes, we present graph embedded topic model (GETM). We offer two main methodological contributions in GETM. First, to aid topic inference, we integrate existing biomedical knowledge graph information in the form of pre-trained graph embedding into the embedded topic model. Second, leveraging deep learning techniques, we developed a variational autoencoder framework to infer patient phenotypic mixture. For interpretability, we use a linear decoder to simultaneously infer the bi-modal distributions of the disease conditions and medications. We applied GETM to UK Biobank (UKB) self-reported clinical phenotype data, which contains conditions and medications for 457,461 individuals. Compared to existing methods, GETM demonstrates overall superior performance in imputing missing conditions and medications. Here, we focused on characterizing pain phenotypes recorded in the questionnaire of the UKB individuals. GETM accurately predicts the status of chronic musculoskeletal (CMK) pain, chronic pain by body-site, and non-specific chronic pain using past conditions and medications. Our analyses revealed not only the known pain-related topics but also the surprising predominance of medications and conditions in the cardiovascular category among the most predictive topics across chronic pain phenotypes.

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Section: Resultsmentioning

confidence: 99%

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

Wang

Benavides

Diatchenko

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Atherosclerosis is a process of deposition of fatty material in the walls of arteries, and this thickening leads to an increase in stroke and heart attack risk. Thus, although the two medications are not directly used as a cure for the condition of high cholesterol, by way of atherosclerosis, high cholesterol leads to higher risk for other cardiovascular outcomes and the medications are used to prevent those outcomes ( Al-Ghamdi et al., 2021 ).…”

Section: Resultsmentioning

confidence: 99%

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK biobank individuals

et al. 2022

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“…[32] Several studies reported the association of chronic pain with hypertension. [33][34][35][36] A previous study in Saudi Arabia reported a significant association between anemia with LBP. [36] Iron deficiency anemia has been linked with the severity of disc degeneration, presumably due to decreased oxygen delivery to tissues.…”

Section: Discussionmentioning

confidence: 96%

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

Waly

Albalawi

Alatawi

et al. 2023

JMSR

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Objectives: Low back pain (LBP) is a main cause of disability worldwide and can negatively affect the individual’s life and work quality. This research aimed to estimate the prevalence of chronic non-specific LBP among the general population of Tabuk city, Saudi Arabia, and to evaluate its related risk factors and functional impairment. Methods: A cross-sectional survey study was performed through a web-based and structured questionnaire consisting of sociodemographic data and risk factors. We used the Modified Oswestry LBP Disability Questionnaire (Arabic version) to measure the disability index among the study participants. The invitation to participate in the questionnaire was posted on different social media platforms. Results: LBP was found in 46% of the participants (n = 768), and it was significantly associated with multiple risk factors, including age group ≥30 years old (P = 0.002), obesity (P = 0.002), smoking (P = 0.004), having comorbidities, particularly anemia, diabetes, hypertension, and hyperthyroidism (P < 0.001), and positive history of psychological problems (P = 0.039). Regular practice of physical activities had a significant protective effect (P = 0.032). The Oswestry Disability Index reported minimal disability among participants who had LBP. Conclusion: The study detected a relatively high prevalence of LBP in Tabuk (46.2%, 95% confidence interval [CI]: 42.7–49.8%) and identified several significant risk factors, including age ≥30 years, body mass index ≥25 kg/m2, smoking, and presence of comorbidities and psychological factors. Regular exercise was a protective factor against chronic LBP. The Oswestry Disability Index showed minimal disability and functional impairment.

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The relationship between chronic pain, prehypertension, and hypertension. A population-based cross-sectional survey in Al-Kharj, Saudi Arabia

Cited by 9 publications

References 23 publications

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK Biobank individuals

A graph-embedded topic model enables characterization of diverse pain phenotypes among UK biobank individuals

Low back pain: Prevalence and functional impairment among the general population in Tabuk city, Saudi Arabia

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