The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

Arias, Natalia; Arboleya, Silvia; Allison, Joseph; Kaliszewska, Aleksandra; Higarza, Sara G.; Gueimonde, Miguel; Árias, Jorge L.

doi:10.3390/nu12082340

Cited by 113 publications

(101 citation statements)

References 196 publications

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“…TMAO also triggers platelet dysfunction, and circulating TMAO levels are associated with the severity of NAFLD and atherosclerosis, ventricular arrhythmias, and clinical outcomes [ 126 , 127 , 128 , 129 , 130 ]. It should be noted that TMAO may be regarded a crucial microbiota-derived biomarker of CVD and potentially also in the cross-talk between NAFLD and CVD; however, TMA/TMAO metabolism not only relies on an imbalance of the intestinal microbiota composition but also on dietary factors, co-metabolism, and host genetics [ 131 ].…”

Section: Possible Mechanisms That Might Explain the Association Bementioning

confidence: 99%

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

Niederseer

Wernly

Aigner

et al. 2021

JCM

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Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative. It is, however, likely that common mechanisms contribute to the development of CVD and NAFLD, with lifestyle factors such as smoking, sedentary lifestyle with poor nutrition habits and physical inactivity being major candidates. These behavioral factors, on a predisposing genetic background, trigger changes in gut microbiota, inflammation, dyslipidemia and oxidative stress, leading to metabolic syndrome, diabetes and obesity as well as atherosclerosis. Treatment options to counteract both the progression and development of CVD and NAFLD include lifestyle interventions, optimal medical therapy of comorbid conditions and, as final possibility, bariatric surgery. As no causal pharmacotherapy of NAFLD is available, further research is urgently needed to address the unmet need of a growing population with NAFLD and CVD.

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Section: Possible Mechanisms That Might Explain the Association Bementioning

confidence: 99%

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

Niederseer

Wernly

Aigner

et al. 2021

JCM

View full text Add to dashboard Cite

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“…TMAO is then transported to tissues or excreted into the urine. TMAO acts atherogenic [120][121][122][123][124]. Updated systematic review and meta-analysis indicate that TMAO increased the hazard ratio (HR) of CHD mortality [125].…”

Section: Debates Around Trimethylamine Oxide (Tmao)mentioning

confidence: 99%

“…From these complex situations, the extent of CVD risk that is attributable to TMAO may also differ individually [124,140]. A higher circulating concentration of TMAO may not simply be interpreted as a marker of unhealthy food intake or an unhealthy dietary pattern.…”

Section: Debates Around Trimethylamine Oxide (Tmao)mentioning

confidence: 99%

Nutritional Viewpoints on Eggs and Cholesterol

Sugano

Matsuoka²

2021

Foods

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Although most current epidemiologic studies indicate no significant association between consuming one egg daily and blood cholesterol levels and cardiovascular risk, arguments still persist with a positive association. Since the diet is one of the most influential factors for this association, we illustrate characteristic features in Japanese people whose dietary pattern is distinct from that, for example, the US (United States) population. Available epidemiologic studies in healthy Japanese people show no association between consumption of one egg daily and blood cholesterol level, consistent with those observed in the US population. However, when consumption of major nutrients and food sources of cholesterol are compared to the US population, Japanese people may have an extra-reserve against the influence of eggs on cardiovascular risk markers, despite consuming relatively more eggs. Further discussion on the influence of nutrients contained in the egg and dietary pattern, including interaction with gut microbes, is necessary. In addition, special consideration at the personalized level is needed for judgment regarding dietary cholesterol not only for hypercholesterolemic patients but for hyper-responsive healthy persons. Although randomized controlled trials with long-term follow-up are required to evaluate the association between consumption of eggs and human health, available information, at least from the nutritional viewpoint, suggests that egg is a healthy and cost-efficient food worldwide.

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“…Similar to folates, choline bioavailability is dependent on several factors. It is modulated by the diet and genome via the microbiota of individuals [ 65 ]. Additionally, the bioavailability is affected by the structure of the choline source [ 66 ].…”

Section: Dietary Supplementation Of 1cmentioning

confidence: 99%

The Antioxidant Role of One-Carbon Metabolism on Stroke

et al. 2020

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One-carbon (1C) metabolism is a metabolic network that is centered on folate, a B vitamin; it integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics. This metabolic pathway also reduces levels of homocysteine, a non-protein amino acid. High levels of homocysteine are linked to increased risk of hypoxic events, such as stroke. Several preclinical studies have suggested that 1C metabolism can impact stroke outcome, but the clinical data are unclear. The objective of this paper was to review preclinical and clinical research to determine whether 1C metabolism has an antioxidant role on stroke. To accomplish the objective, we searched for publications using the following medical subject headings (MeSH) keywords: antioxidants, hypoxia, stroke, homocysteine, one-carbon metabolism, folate, methionine, and dietary supplementation of one-carbon metabolism. Both pre-clinical and clinical studies were retrieved and reviewed. Our review of the literature suggests that deficiencies in 1C play an important role in the onset and outcome of stroke. Dietary supplementation of 1C provides beneficial effects on stroke outcome. For stroke-affected patients or individuals at high risk for stroke, the data suggest that nutritional modifications in addition to other therapies could be incorporated into a treatment plan.

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The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases

Cited by 113 publications

References 196 publications

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and Therapeutic Considerations

Nutritional Viewpoints on Eggs and Cholesterol

The Antioxidant Role of One-Carbon Metabolism on Stroke

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