The relationship between childhood emotional abuse and chronic pain among people who inject drugs in Vancouver, Canada

Prangnell, Amy; Voon, Pauline; Shulha, Hennady P.; Nosova, Ekaterina; Shoveller, Jean; Milloy, M.‐J.; Hayashi, Kanna

doi:10.1016/j.chiabu.2019.05.006

Cited by 7 publications

(4 citation statements)

References 62 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high prevalence of chronic pain in MOUD populations allowed us to examine the relationship between trauma exposure and chronic pain. Congruent with previous studies among individuals with and without SUD, our study found that individuals with OUD and chronic pain were more likely to report traumatic accidents (e.g., car accidents, falls, natural disasters) ( 27 – 30 , 32 , 33 , 35 – 37 , 49 ). Impaired cortisol secretion and psychological stress in response to a traumatic injury/ accident has been associated with development of chronic pain over time ( 27 ).…”

Section: Discussioncontrasting

confidence: 69%

“…without SUD (27). The relationship between exposure to interpersonal trauma, childhood trauma in particular, and the development of chronic pain has also been established in the general population (28-30), replicated in SUD populations (31) and documented in OUD populations (32)(33)(34)(35)(36). However, in most studies examining chronic pain or OUD, childhood trauma exposure has been de ned and limited to single types of childhood abuse or neglect (33,37).…”

Section: Introductionmentioning

confidence: 94%

See 1 more Smart Citation

Trauma Exposure Across the Lifespan among Individuals Engaged in Treatment with Medication for Opioid Use Disorder: Differences by Gender, PTSD Status, and Chronic Pain

Rodríguez,

Colgan,

Leyde

et al. 2023

Preprint

View full text Add to dashboard Cite

Background There is little study of lifetime trauma exposure among individuals engaged in medication treatment for opioid use disorder (MOUD). A multisite study provided the opportunity to examine the prevalence of lifetime trauma and differences by gender, PTSD status, and chronic pain. Methods A cross-sectional study examined baseline data from participants (N = 303) enrolled in a randomized controlled trial of a mind-body intervention as an adjunct to MOUD. All participants were stabilized on MOUD. Measures included the Trauma Life Events Questionnaire (TLEQ), the Brief Pain Inventory (BPI), and the Posttraumatic Stress Disorder Checklist (PCL-5). Analyses involved descriptive statistics, independent sample t-tests, and linear and logistic regression. Results Participants were self-identified as women (n = 157), men (n = 144), and non-binary (n = 2). Fifty-seven percent (n = 172) self-reported chronic pain, and 41% (n = 124) scored above the screening cut-off for PTSD. Women reported significantly more intimate partner violence (85%) vs 73%) and adult sexual assault (57% vs 13%), while men reported more physical assault (81% vs 61%) and witnessing trauma (66% vs 48%). Men and women experienced substantial childhood physical abuse, witnessed intimate partner violence as children, and reported an equivalent exposure to accidents as adults. The number of traumatic events predicted PTSD symptom severity and PTSD diagnostic status. Participants with chronic pain, compared to those without chronic pain, had significantly more traumatic events in childhood (85% vs 75%). Conclusions The study found a high prevalence of lifetime trauma among people in MOUD. Results highlight the need for comprehensive assessment and mental health services to address trauma among those in MOUD treatment. Trial Registration: NCT04082637

show abstract

Section: Discussioncontrasting

confidence: 69%

Section: Introductionmentioning

confidence: 94%

Trauma Exposure Across the Lifespan among Individuals Engaged in Treatment with Medication for Opioid Use Disorder: Differences by Gender, PTSD Status, and Chronic Pain

Rodríguez,

Colgan,

Leyde

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“… 30 31 72 42 45 93 50 53 8 In those with chronic pain, previous childhood adversity should be assessed. 26, 28 , 29 , 56 61 71 39 74 60 41 42 67 45 84 91 82, 49 , 76 , 93 52 85 92 23 Screening for mental health should be considered for those with chronic pain. 57 31 39 41 42 67 45 80 82 93 70 9 Education on the awareness of childhood adversity on pain needs to be more widespread.…”

Section: Resultsmentioning

confidence: 99%

What is the association between childhood adversity and subsequent chronic pain in adulthood? A systematic review

Nicolson¹,

Mills²,

Senaratne³

et al. 2023

BJA Open

View full text Add to dashboard Cite

“…In studies assessing the impact of childhood emotional violence on pain perception disturbances in populations with diagnosed mental health disorders, attention was drawn to the fact that among individuals receiving injectable drugs for chronic pain, experiences of childhood emotional violence were common, partly influenced by a history of diagnosed mental health disorders [107]. Similarly, it is known that individuals with mental health disorders have a high incidence of childhood trauma; however, little is known about how childhood emotional violence may be associated with chronic pain in this population [108]. Available data suggest that physicians should consider childhood trauma when treating psychiatric disorders in individuals experiencing chronic pain.…”

Section: Part IIImentioning

confidence: 99%

Myo-inositol’s Role in Understanding the Pain Perception in Patients with Schizophrenia

Krzyściak,

Szwajca,

Karcz

et al. 2024

New Approaches to the Management and Diagnosis of Schizophrenia [Working Title]

View full text Add to dashboard Cite

The molecular explanation for the changes in pain perception in schizophrenia lies in nerve inflammation. The decrease in inositol, mainly localized in glial cells, can support these changes. There are also significant alterations in the viability and functioning of neurons, which are linked to a significant reduction of N-acetyl-aspartate (NAA). Our study demonstrates significantly increased myo-inositol levels in the anterior and posterior cingulate cortex. An increase in the myo-inositol/sum of the creatinine and phosphocreatinine (Cr + PCr) ratio and NAA levels additionally supports the notion of inositol’s beneficial impact on brain metabolism and neuronal integrity, which is particularly relevant to schizophrenia’s neurodegenerative changes. However, varying NAA/Cr + PCr ratios indicate a complex interaction between the brain’s inositol level and energy metabolism or neurochemical balance. These findings highlight inositol’s potential role in modulating neurochemical profiles in schizophrenia. Furthermore, high inositol levels are linked to significant reductions in trauma-related symptoms in schizophrenia, as indicated by the International Trauma Questionnaire and the Child Trauma Questionnaire. Inositol’s potential to mitigate trauma effects, and enhance social functioning and its multifaceted role in schizophrenia, offers a promising avenue for further research into its therapeutic applications.

show abstract

The relationship between childhood emotional abuse and chronic pain among people who inject drugs in Vancouver, Canada

Cited by 7 publications

References 62 publications

Trauma Exposure Across the Lifespan among Individuals Engaged in Treatment with Medication for Opioid Use Disorder: Differences by Gender, PTSD Status, and Chronic Pain

Trauma Exposure Across the Lifespan among Individuals Engaged in Treatment with Medication for Opioid Use Disorder: Differences by Gender, PTSD Status, and Chronic Pain

What is the association between childhood adversity and subsequent chronic pain in adulthood? A systematic review

Myo-inositol’s Role in Understanding the Pain Perception in Patients with Schizophrenia

Contact Info

Product

Resources

About