The relationship between bronchiolitis and allergic asthma

Zweiman, Burton; Schoenwetter, William F.; Hildreth, Eugene A.

doi:10.1016/0021-8707(66)90109-2

Cited by 50 publications

(13 citation statements)

References 8 publications

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“…In this study, 20 elevated blood eosinophil counts were not a risk factor for recurrent wheezing or asthma, which is consistent with previous observations. Our recent reports showed that high concentrations of serum 10 and nasopharyngeal ECP 14 were predictive of bronchial obstructions, and especially of episodes requiring hospital treatment.…”

Section: Discussionsupporting

confidence: 95%

“…8,19 In our 1-year follow-up, 12 of the 13 children (92%) with a history of wheezing developed asthma, and only one (8%) had no subsequent wheezing. In accordance with some previous studies, children who have atopy 5,9,19 or family history of atopy 20,21 were prone to recurrent wheezing and asthma. Contrary to previous observations of population based studies, male gender 21,22 family history of asthma 5,23 or passive smoking [21][22][23][24] were not significant risk factors for recurrent wheezing or asthma.…”

Section: Discussionsupporting

confidence: 92%

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One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma

Reijonen

Korppi

1998

Pediatr. Pulmonol.

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We investigated the 1‐year outcome of children hospitalized for wheezing, paying special attention to the effect of early anti‐inflammatory therapy. In addition, we identified risk factors for recurrent wheezing and asthma. Eighty‐eight children under 2 years old treated in the hospital for wheezing were followed for 1 year. Nebulized anti‐inflammatory therapy was given for 16 weeks: 31 patients received budesonide, 29 patients cromolyn sodium, and 28 control patients received no therapy. The number of subsequent physician‐diagnosed wheezing episodes was recorded. Four months of anti‐inflammatory therapy did not significantly decrease the occurrence of asthma 1 year later; 45% of patients in the cromolyn group, 42% in the budesonide group, and 61% in the control group had asthma, defined as at least two bronchial obstruction episodes during the 1‐year period after the original hospitalization for wheezing. An age over 12 months at the time of the initial bronchial obstructing episode [P = 0.009, risk ratio (RR) = 5.4, 95% confidence interval (CI) = 1.53–19.31], failure to identify a viral cause (P = 0.0003, RR = 12.0, CI = 3.16–45.40), history of wheezing (P = 0.02, RR = 14.6, CI = 1.59–132.10), the presence of atopy (P = 0.01, RR = 5.3, CI = 1.47–19.21), a family history of atopy (P = 0.03, RR = 3.6, CI = 1.15–11.12), and serum eosinophil cationic protein (ECP) ≥ 16 μg/L (P = 0.005) were significant risk factors for asthma. We conclude that early anti‐inflammatory therapy for 4 months does not significantly decrease the occurrence of asthma during the period of 1 year following hospitalization for the original episode of wheezing. Young children requiring hospital admission for wheezing during a respiratory tract infection are at increased risk of having subsequent asthma if they have wheezed previously, if they have atopy or a family history of atopy, if they have elevated serum ECP, if they are over 12 months of age at the original bronchial obstructive episode, and especially when viral studies are negative. Pediatr Pulmonol. 1998; 26:113–119. © 1998 Wiley‐Liss, Inc.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionsupporting

confidence: 92%

One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma

Reijonen

Korppi

1998

Pediatr. Pulmonol.

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“…3 Respiratory syncytial virus is the major cause of bronchiolitis in the first year of life.4 It may also precipitate wheeze in susceptible older children.5 Simon and Jordan suggested that children with bronchiolitis due to respiratory syncytial virus were no more likely to wheeze subsequently than other children but that those who had features of bronchiolitis without respiratory syncytial virus infection were manifesting early asthma and often suffered further recurrent wheezing.6 Rooney and Williams, however, looked at 62 children with proved respiratory syncytial virus bronchiolitis in the first 18 months of life and found that 35 had further wheezing.7 They also found an increased prevalence of atopy in these children and their families. The high incidence of subsequent recurrent wheeze was confirmed by Sims et al,8 but they failed to find an increased incidence of atopy in the 26 children who were examined in detail eight years after admission in infancy for respiratory syncytial virus bronchiolitis.9…”

Section: Introductionmentioning

confidence: 99%

Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy.

Pullan¹,

Hey²

1982

BMJ

563

293

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Of the 180 children admitted to hospitals in Tyneside in the first year of life with proved respiratory syncytial virus lower respiratory tract infection, 130 were seen for review 10 years later and 34 of the remaining 50 children accounted for. Skin tests, lung function tests, and histamine-challenge and exercise tests for bronchial lability were undertaken in over 100 of the index children and a similar number of control children. A total of 55 (42%) of the 130 index children had had further episodes of wheeze, while only 21 (19%) out of 111 controls had ever wheezed; but few (6-2% v 4-5%) had troublesome symptoms at the age of 10. There was a threefold increase in the incidence of bronchial lability in the index children but no excess of atopy. Maximum expiratory air flow was reduced throughout the vital capacity manoeuvre in the index children, even when those with a history of recurrent wheeze were excluded. Results of single-breath nitrogen washout tests were normal, however, suggesting that ventilation was not appreciably uneven, even though expiratory flow was restricted. These differences might have been caused by infection damaging the growing lung but might also be explained by pre-existing differences in the airway, rendering certain children more susceptible to symptomatic infection when first challenged by the virus in infancy.

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“…Recommended criteria for the diagnosis of bronchiolitis include the following: (1) expiratory wheezing of acute onset, (2) an age of 24 months or less, (3) signs of viral respiratory illness such as coryza, otitis media, or fever, (4) the first such episode, and (5) the presence or absence of indica¬ tions of respiratory distress, pneumonia, or atopy.10"12…”

Section: Definition Of Bronchiolitis Episodesmentioning

confidence: 99%

Predicting Clinically Significant Lower Respiratory Tract Illness in Childhood Following Mild Bronchiolitis

McConnochie¹,

Roghmann²

1985

Arch Pediatr Adolesc Med

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The relationship between bronchiolitis and allergic asthma

Cited by 50 publications

References 8 publications

One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma

One-year follow-up of young children hospitalized for wheezing: the influence of early anti-inflammatory therapy and risk factors for subsequent wheezing and asthma

Wheezing, asthma, and pulmonary dysfunction 10 years after infection with respiratory syncytial virus in infancy.

Predicting Clinically Significant Lower Respiratory Tract Illness in Childhood Following Mild Bronchiolitis

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