The relationship between brain structure and neurocognition in schizophrenia: a selective review

Antonova, Elena

doi:10.1016/j.schres.2003.12.002

Cited by 363 publications

(260 citation statements)

References 107 publications

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“…These discordant deficits in the clinical and cognitive domains of schizophrenics also were consistent with a previous study (Hughes et al, 2003). Similarly, these sex differences in cognitive domains are consistent with previous studies (Antonova et al, 2004;Halari et al, 2006;Sota and Heinrichs, 2003), and have been suggested as due to differences in brain structure for the two sexes and to differences in neural lateralization (Antonova et al, 2004). One study indicated greater right hemispheric specificity for males' and bilateral representations for females' brains (Gur et al, 2000) and greater leftward asymmetry of frontal lobe fractional anisotropy in females than males (Szeszko et al, 2003).…”

Section: Discussionsupporting

confidence: 92%

“…These results are consistent with other phenomenological studies (Goldstein et al, 1998, Sota and Heinrichs, 2003, Halari et al, 2006. For example, abnormalities in the frontal lobe and hippocampal volume are associated with cognitive deficits in executive functioning, working memory, verbal fluency and immediate memory among schizophrenics (DeLisi et al, 1991, Antonova et al, 2004, suggesting that the cognitive deficits of schizophrenia may be associated with these brain abnormalities. Also, the cognitive deficits of schizophrenia were found to be associated with abnormal neurotransmitter systems in the brain and with genetic mutations (Friston et al, 1991;Stefansson et al, 2009).…”

Section: Discussionsupporting

confidence: 91%

“…The explanations and hypotheses about the gender differences in cognitive tasks in both schizophrenia and healthy populations include abnormalities in brain structure and volume, abnormal function of neurotransmitter systems, gonadal hormone differences and genetic effects (Antonova et al, 2004;Friston et al, 1991;Stefansson et al, 2009;Wegesin and Stern, 2007). However, the evidence is still not clear whether gender differences occur in the cognitive deficits of schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gender differences in cognitive function of patients with chronic schizophrenia

Han¹,

Huang²,

Chen³

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

120

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Schizophrenic patients have cognitive impairments, but gender differences in these cognitive deficits have had limited study. This study assessed cognitive functioning in 471 subjects including 122 male and 78 female schizophrenic patients and 141 male and 130 female healthy controls. We found that immediate memory, language, delayed memory and total RBANS scores were significantly decreased in schizophrenia compared with healthy controls for both genders. Male patients had significant lower immediate memory, delayed memory and total RBANS scores than female patients, and healthy controls showed a similar gender difference. The RBANS showed modest correlations with PANSS scores, duration of illness and antipsychotic dose (chlorpromazine equivalents). Almost all RBANS scores in the schizophrenics and healthy controls showed significant positive correlations with education. Thus, patients of both sexes with schizophrenia experienced more deteriorated performance than healthy controls on cognitive domains of immediate memory, language and delayed memory. Furthermore, male schizophrenic patients had more serious cognitive deficits than female patients in immediate and delayed memory, but not in language, visuospatial and attention indices. AbstractSchizophrenic patients have cognitive impairments, but gender differences in these cognitive deficits have had limited study. This study assessed cognitive functioning in 471 subjects including 172 male and 78 female schizophrenic patients and 141 male and 130 female healthy controls. We found that immediate memory, language, delayed memory and total RBANS scores were significantly decreased in schizophrenia compared with healthy controls for both genders. Male patients had significant lower immediate memory, delayed memory and total RBANS scores than female patients, and healthy controls showed a similar gender difference. The RBANS showed modest correlations with PANSS scores, duration of illness and antipsychotic dose (chlorpromazine equivalents). Almost all RBANS scores in the schizophrenics and healthy controls showed significant positive correlations with education. Thus, patients of both sexes with schizophrenia experienced more deteriorated performance than healthy controls on cognitive domains of immediate memory, language and delayed memory.Furthermore, male schizophrenic patients had more serious cognitive deficits than female patients in immediate and delayed memory, but not in language, visuospatial and attention indices.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Gender differences in cognitive function of patients with chronic schizophrenia

Han¹,

Huang²,

Chen³

et al. 2012

Progress in Neuro-Psychopharmacology and Biological Psychiatry

120

View full text Add to dashboard Cite

show abstract

“…19 Thus, it remains a possibility that substance dependence may have contributed to the lack of findings for the dorsolateral PFC. Also, evidence to-date supporting a significant association between structure and function has come largely from studies examining regional gray-matter volumes, 20 whereas evidence of such correlations for cortical thickness is lacking. Therefore, it is possible that increased perseverative errors in individuals with psychopathy would correlate with reduced gray-matter volume in the dorsolateral PFC, despite the lack of findings for cortical thickness in this study.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Structural Correlates of Response Perseveration in Individuals With Psychopathy

Yang¹,

Raine²,

Colletti³

et al. 2011

Journal of Neuropsychiatry

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Structural deficits in the frontotemporal network have been shown in individuals with psychopathy and are posited to contribute to neuropsychological impairments such as response perseveration. However, no study to date has examined structural correlates of response perseveration in individuals with psychopathy. In this structural MRI study, the authors found higher correlations between increased response perseveration and reduced cortical thickness in the orbitofrontal and anterior temporal regions in individuals with psychopathy than in healthy-comparison subjects. The findings provide preliminary evidence suggesting potential contributions of frontotemporal structural deficits in neurocognitive impairment with perseveration in individuals with psychopathy.

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“…It is possible that the duration of illness effect may be localised to specific regions within the cerebellum. Deficits may be localized to certain areas that are related to cognitive function [41][42][43] and functional outcome [44]. Cerebellum has been traditionally considered in terms of its role in balance and motor coordination.…”

mentioning

confidence: 99%

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

Premkumar

Fannon

Kuipers

et al. 2008

Behavioural Brain Research

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P r e -P r i n t AbstractThe frontal lobe has an extended maturation period and may be vulnerable to the long-term effects of schizophrenia. We tested this hypothesis by studying the relationship between duration of illness (Dol) and grey matter (GM) volume across the whole brain. Sixty-four patients with schizophrenia and 25 healthy controls underwent structural MRI scanning and neuropsychological assessment. We performed regression analyses in patients to examine the relationship between Dol and GM and cerebro-spinal fluid (CSF) volumes across the whole brain, and correlations in controls between age and GM or CSF volume of the regions where GM or CSF volumes were associated with Dol in patients. Correlations were also performed between GM volume in the regions associated with Dol and neuropsychological performance.A longer Dol was associated with lower GM volume in the left dorsomedial prefrontal cortex (PFC), right middle frontal cortex, left fusiform gyrus (FG) and left cerebellum (lobule III).Additionally, age was inversely associated with GM volume in the left dorsomedial PFC in patients, and in the left FG and CSF excess near the left cerebellum in healthy controls.Greater GM volume in the left dorsomedial PFC was associated with better working memory, attention and psychomotor speed in patients. Our findings suggest that the right middle frontal cortex is particularly vulnerable to the long-term effect of schizophrenia illness whereas the dorsomedial PFC, FG and cerebellum are affected by both a long Dol and aging. The effect of illness chronicity on GM volume in the left dorsomedial PFC may be extended to brain structureneuropsychological function relationships. 2

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The relationship between brain structure and neurocognition in schizophrenia: a selective review

Cited by 363 publications

References 107 publications

Gender differences in cognitive function of patients with chronic schizophrenia

Gender differences in cognitive function of patients with chronic schizophrenia

Abnormal Structural Correlates of Response Perseveration in Individuals With Psychopathy

Association between a longer duration of illness, age and lower frontal lobe grey matter volume in schizophrenia

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