The Relationship Between Bone Mineral Density Values and Prognostic Nutritional Index As Well As Serum Trace Element Levels in Postmenopausal Women

Kul, Ayhan; Bayraktutan, Zafer; Çelik, Mine

doi:10.4274/tod.galenos.2020.97658

Cited by 1 publication

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“…Five case-control studies covering 508 subjects reported the difference of serum selenium between OP and healthy subjects. 34 , 40 , 44 - 46 The result from the random-effect model did not support a statistically significant difference of serum selenium between OP patients and healthy controls (WMD = -7.48, 95% CI -15.81 to 0.84; p = 0.078). To assess the stability of the result and the influence of each study, we performed a sensitivity analysis.…”

Section: Resultsmentioning

confidence: 79%

“…Eventually, 19 studies covering a total of 69,672 subjects met our inclusion criteria (Figure 1). [27][28][29][30][31][34][35][36][37][38][39][40][41][42][43][44][45][46][47] Of these studies, 18 were observational studies (eight had a cross-sectional design, seven had a case-control design, and three had a prospective design), except for one RCT. Across the included studies, the number of participants ranged from 60 to 21,939, while the mean age varied from 39.4 to 75.8 years, with mean selenium intake ranging from 41.2 to 154.4 μg/d or mean serum selenium level ranging from 66.7 to 131.1 μg/l (Tables I and II).…”

Section: Resultsmentioning

confidence: 99%

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The association between selenium and bone health: a meta-analysis

Xie

Wang

et al. 2023

Bone Joint Res

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AimsPrevious studies have suggested that selenium as a trace element is involved in bone health, but findings related to the specific effect of selenium on bone health remain inconclusive. Thus, we performed a meta-analysis by including all the relevant studies to elucidate the association between selenium status (dietary intake or serum selenium) and bone health indicators (bone mineral density (BMD), osteoporosis (OP), or fracture).MethodsPubMed, Embase, and Cochrane Library were systematically searched to retrieve relevant articles published before 15 November 2022. Studies focusing on the correlation between selenium and BMD, OP, or fracture were included. Effect sizes included regression coefficient (β), weighted mean difference (WMD), and odds ratio (OR). According to heterogeneity, the fixed-effect or random-effect model was used to assess the association between selenium and bone health.ResultsFrom 748 non-duplicate publications, 19 studies were included. We found a significantly positive association between dietary selenium intake (β = 0.04, 95% confidence interval (CI) 0.00 to 0.07, p = 0.029) as well as serum selenium (β = 0.13, 95% CI 0.00 to 0.26, p = 0.046) and BMD. Consistently, those with higher selenium intake had a lower risk of OP (OR = 0.47, 95% CI 0.31 to 0.72, p = 0.001), and patients with OP had a significantly lower level of serum selenium than healthy controls (WMD = -2.01, 95% CI -3.91 to -0.12, p = 0.037). High dietary selenium intake was associated with a lower risk of hip fracture (OR = 0.44, 95% CI 0.37 to 0.52, p < 0.001).ConclusionSelenium was positively associated with BMD and inversely associated with OP; dietary selenium intake was negatively associated with hip fracture. The causality and therapeutic effect of selenium on OP needs to be investigated in future studies.Cite this article: Bone Joint Res 2023;12(7):423–432.

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Section: Resultsmentioning

confidence: 79%