The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

Malczewska-Lenczowska, Jadwiga; Surała, Olga; Granda, Dominika; Szczepańska, Beata; Czaplicki, Adam; Kubacki, Rafał

doi:10.3390/nu16020215

Cited by 3 publications

(1 citation statement)

References 60 publications

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“…It plays a crucial role in muscular skeletal health. It enhances the absorption of calcium and phosphorus from the intestines, promoting deposition in bones and maintaining bone mineralization [ 82 ]. Meanwhile, gross vitamin D deficiency leads to conditions like rickets in children and osteomalacia in adults, characterized by weakened and brittle bones [ 35 , 37 , 68 ].…”

Section: Generation Of Vitamin Dmentioning

confidence: 99%

Physiology of Vitamin D—Focusing on Disease Prevention

Wimalawansa

2024

Nutrients

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Vitamin D is a crucial micronutrient, critical to human health, and influences many physiological processes. Oral and skin-derived vitamin D is hydroxylated to form calcifediol (25(OH)D) in the liver, then to 1,25(OH)2D (calcitriol) in the kidney. Alongside the parathyroid hormone, calcitriol regulates neuro-musculoskeletal activities by tightly controlling blood-ionized calcium concentrations through intestinal calcium absorption, renal tubular reabsorption, and skeletal mineralization. Beyond its classical roles, evidence underscores the impact of vitamin D on the prevention and reduction of the severity of diverse conditions such as cardiovascular and metabolic diseases, autoimmune disorders, infection, and cancer. Peripheral target cells, like immune cells, obtain vitamin D and 25(OH)D through concentration-dependent diffusion from the circulation. Calcitriol is synthesized intracellularly in these cells from these precursors, which is crucial for their protective physiological actions. Its deficiency exacerbates inflammation, oxidative stress, and increased susceptibility to metabolic disorders and infections; deficiency also causes premature deaths. Thus, maintaining optimal serum levels above 40 ng/mL is vital for health and disease prevention. However, achieving it requires several times more than the government’s recommended vitamin D doses. Despite extensive published research, recommended daily intake and therapeutic serum 25(OH)D concentrations have lagged and are outdated, preventing people from benefiting. Evidence suggests that maintaining the 25(OH)D concentrations above 40 ng/mL with a range of 40–80 ng/mL in the population is optimal for disease prevention and reducing morbidities and mortality without adverse effects. The recommendation for individuals is to maintain serum 25(OH)D concentrations above 50 ng/mL (125 nmol/L) for optimal clinical outcomes. Insights from metabolomics, transcriptomics, and epigenetics offer promise for better clinical outcomes from vitamin D sufficiency. Given its broader positive impact on human health with minimal cost and little adverse effects, proactively integrating vitamin D assessment and supplementation into clinical practice promises significant benefits, including reduced healthcare costs. This review synthesized recent novel findings related to the physiology of vitamin D that have significant implications for disease prevention.

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Section: Generation Of Vitamin Dmentioning

confidence: 99%

Physiology of Vitamin D—Focusing on Disease Prevention

Wimalawansa

2024

Nutrients

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Evaluation of the Concentration of Selected Elements in the Serum of Patients with Degenerative Stenosis of the Lumbosacral Spine

Sobański,

Staszkiewicz,

Filipowicz

et al. 2024

Biol Trace Elem Res

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Advanced Sports Nutrition Assessment Technique

Butt,

Ahmed

2024

Advances in Medical Diagnosis, Treatment, and Care

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Modern methods of advanced sports nutrition assessment have emerged that can highlight efficient wellness and performance at the time for athletes as well as their coaches. The purpose of this chapter is to cover current methodologies for the measurement of nutritional status and body composition in athletes with an emphasis on practical applications of science. We first talk about the tool that is dietary analysis and why it's important to understand what macronutrients, and micronutrients you are consuming. This section assesses their strengths and weaknesses as well as looking at food diaries, 24-hour dietary recalls, and food frequency questionnaires. Through this data, the tools can help nutritionists in developing individualized diet plans. In part 2, we move on to assess your metabolic rate and continue with a discussion of the use of indirect calorimetry to determine RMR as well as an athlete's total energy expenditure (TEE).

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The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males

Cited by 3 publications

References 60 publications

Physiology of Vitamin D—Focusing on Disease Prevention

Physiology of Vitamin D—Focusing on Disease Prevention

Evaluation of the Concentration of Selected Elements in the Serum of Patients with Degenerative Stenosis of the Lumbosacral Spine

Advanced Sports Nutrition Assessment Technique

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