The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer

Wissing, Michel D.; Chevalier, Simone; Laprise, Claudie; Aprikian, Saro; O'Flaherty, Ana; Scarlata, Eleonora; Saad, Fred; Carmel, Michel; Lacombe, Louis; Brimo, Fadi; Latour, Mathieu; Ekindi-Ndongo, Nadia; Têtu, Bernard; Aprikian, Armen

doi:10.1007/s00345-018-2457-6

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…If the prognosis of obese PCa patients is poor, this indicates that weight control may be able to effectively reduce morbidity and mortality. However, several large cohort studies did not nd the association between physical activity and locally advanced, high-risk PCa or treatment failure [25,26]. Overweight or obesity is associated with an increased risk of some chronic diseases, such as diabetes and cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Impact of Obesity on Adverse Pathological Characteristics After Radical Prostatectomy

Xia¹,

Zhuo²,

Li³

et al. 2021

Preprint

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Background: The effect of obesity on pathological features was different from country to country in other studies. To investigate whether obesity affected pathological characteristics of PCa after laparoscopic radical prostatectmy (LRP) in Chinese man.Methods: Medical record of 670 Chinese patients who underwent LRP between 2018 and 2020 were retrospectively reviewed. Patient height and weight were meaured before surgery to calculate the body mass index (BMI). They were categorized into three groups according to Chinese classification of obesity: normol weight (BMI＜24.0kg/m2),overweight (24.0 ≤ BMI ＜28.0kg/m2) and obese(BMI≥28.0kg/m2). The associations between BMI and operating age, preoperative prostate-specific antigen (PSA) level, were assessed with the Kruskal-Wallis test. The associations between BMI and pathological features were assessed with chi –square test.Results: Of the 670 patients, 31.5% patients were normal weight, 51.3% were overweight, 17.2% were obese. Operating age (P=0.029) tend to decrease as BMI increased. Seminal vesicle invasion differ significantly among BMI categoties (P=0.003), and other adverse pathologic characteristics , such as positive surgical margin (PSM) (P=0.851), International Society of Urological Pathology (ISUP) grade(P=0.194), extracapsular extension(P=0.460) were not associated with BMI categoties. In the Logistic regression model, higher BMI was an independent risk factors for seminal vesicle invasion after adjusting for multiple clinical preoperative characteristics.Conclusions: Overweight and obese Chinese PCa patients treated by LRP had lower operating age compared to normal weight patients. Seminal vesicle invasion was associated with higher BMI and other adverse pathologic characteristics are not significantly affected by BMI.

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Section: Discussionmentioning

confidence: 99%

Impact of Obesity on Adverse Pathological Characteristics After Radical Prostatectomy

Xia¹,

Zhuo²,

Li³

et al. 2021

Preprint

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“…(24,25) Conversely, BMI has often been shown to have an association with BCR after RP and is an independent predictor of BCR survival. (26)(27)(28) Conclusions A short PSA TTN after RP of < 3 months versus a longer TTN of 3-6 months appears to predict risk of BCR, but not more robust oncologic endpoints such as OS or PCSM. The PSA nadir post-surgery (detectable vs undetectable) is a stronger predictor of BCR than is TTN.…”

Section: Discussionmentioning

confidence: 99%

Time to Prostate-Specific Antigen Nadir After Radical Prostatectomy – a new potential predictive prognostic parameter and its impact on clinical outcomes

Tran¹,

Moretti²,

O’Callaghan³

2020

Preprint

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BackgroundTo investigate and validate previously published associations between time to prostate-specific antigen nadir and the time-to-nadir after radical prostatectomy with biochemical recurrence and to extend this analysis to overall survival and prostate cancer-specific mortality risk. MethodsThis is a retrospective analysis of 1796 men from the South Australian Prostate Cancer Clinical Outcomes Collaborative database treated with radical prostatectomy between 1998-2018 with available prostate-specific antigen nadir data within 1-6 months after surgery. Uni- and multivariable analyses of prostate-specific antigen nadir, time-to-nadir, biochemical recurrence and death were performed with Cox and competing risks models (adjusted for age, surgery year, tumour features and preoperative prostate-specific antigen).ResultsThe univariable analysis demonstrated those with shorter time-to-nadir <3 months had a decreased risk of biochemical recurrence (log-rank, p=0.0098) compared to those with longer time-to-nadir 3-6 months. For men with a time-to-nadir <3 months, a Log-rank test showed a decreased risk of prostate cancer-specific mortality (p=0.026) compared to time-to-nadir 3-6 months, without a difference in overall survival. Multivariable competing risk analyses indicated that biochemical recurrence was more likely when time-to-nadir was 3-6 months compared to <3 months (sHR=1.43, CI 1.01-2.02, p=0.04).ConclusionsAmong men undergoing radical prostatectomy, a shorter post-operative time-to-nadir <3 months is associated with decreased risk of biochemical recurrence compared to time-to-nadir 3-6 months. Following adjustment for confounders and competing risks, there was no significant difference in time-to-nadir for mortality outcomes.

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Impact of obesity on perioperative, functional and oncological outcomes after robotic-assisted radical prostatectomy in a high-volume center

et al. 2022

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The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer

Abstract: BMI was an independent predictor for locally advanced, high-risk disease in this cohort of PCa patients undergoing RP, but was unrelated to treatment failure. Physical activity was not related to locally advanced, high-risk PCa or treatment failure.

Cited by 9 publications

References 24 publications

Impact of Obesity on Adverse Pathological Characteristics After Radical Prostatectomy

Impact of Obesity on Adverse Pathological Characteristics After Radical Prostatectomy

Time to Prostate-Specific Antigen Nadir After Radical Prostatectomy – a new potential predictive prognostic parameter and its impact on clinical outcomes

Impact of obesity on perioperative, functional and oncological outcomes after robotic-assisted radical prostatectomy in a high-volume center

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