The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats

Goktepe, Emre; Baltaci, Saltuk Bugra; Unal, Omer; Unlukal, Nejat; Mogulkoc, Rasim; Baltaci, Abdulkerim Kasim

doi:10.1016/j.jtemb.2023.127217

Cited by 3 publications

(2 citation statements)

References 30 publications

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“…SLC30A8, also known as zinc transporter 8 (ZnT8), is a pivotal gene implicated in the pathogenesis of Gestational Diabetes Mellitus (GDM) ( 50 ). This gene regulates zinc homeostasis by facilitating zinc transport into pancreatic beta cells, which is crucial for insulin synthesis and secretion ( 51 ). Several studies have indicated that variations in the SLC30A8 gene influence susceptibility to GDM ( 52 – 54 ).…”

Section: The Role Of Genetic Factors In the Development Of Gestationa...mentioning

confidence: 99%

“…Nonetheless, the critical involvement of SLC30A8 and ZnT8 in insulin secretion underscores their potential influence on GDM susceptibility. Additionally, a study in animal models highlights the potential therapeutic benefits of zinc supplementation in restoring beta cell function and mitigating GDM risk ( 51 ). Intraperitoneal zinc supplementation in rats restored ZnT8 levels and improved beta cell function, emphasizing the therapeutic potential of targeting SLC30A8 in GDM management ( 51 ).…”

Section: The Role Of Genetic Factors In the Development Of Gestationa...mentioning

confidence: 99%

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Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Ray,

Zeng,

Kusi

et al. 2024

Front. Endocrinol.

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Gestational diabetes mellitus (GDM) poses a significant global health concern, impacting both maternal and fetal well-being. Early detection and treatment are imperative to mitigate adverse outcomes during pregnancy. This review delves into the pivotal role of insulin function and the influence of genetic variants, including SLC30A8, CDKAL1, TCF7L2, IRS1, and GCK, in GDM development. These genetic variations affect beta-cell function and insulin activity in crucial tissues, such as muscle, disrupting glucose regulation during pregnancy. We propose a hypothesis that this variation may disrupt zinc transport, consequently impairing insulin production and secretion, thereby contributing to GDM onset. Furthermore, we discussed the involvement of inflammatory pathways, such as TNF-alpha and IL-6, in predisposing individuals to GDM. Genetic modulation of these pathways may exacerbate glucose metabolism dysregulation observed in GDM patients. We also discussed how GDM affects cardiovascular disease (CVD) through a direct correlation between pregnancy and cardiometabolic function, increasing atherosclerosis, decreased vascular function, dyslipidemia, and hypertension in women with GDM history. However, further research is imperative to unravel the intricate interplay between inflammatory pathways, genetics, and GDM. This understanding is pivotal for devising targeted gene therapies and pharmacological interventions to rectify genetic variations in SLC30A8, CDKAL1, TCF7L2, IRS1, GCK, and other pertinent genes. Ultimately, this review offers insights into the pathophysiological mechanisms of GDM, providing a foundation for developing strategies to mitigate its impact.

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Section: The Role Of Genetic Factors In the Development Of Gestationa...mentioning

confidence: 99%

Section: The Role Of Genetic Factors In the Development Of Gestationa...mentioning

confidence: 99%

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Ray,

Zeng,

Kusi

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats

Gumus,

Gulbahce-Mutlu,

Unal

et al. 2023

Biol Trace Elem Res

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Zinc deficiency affects insulin secretion and alters insulin-regulated metabolic signaling in rats

Nakamura,

Kido,

Seki

et al. 2024

Journal of Trace Elements in Medicine and Biology

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The relationship between beta cell activation and SLC30A8/ZnT8 levels of the endocrine pancreas and maternal zinc deficiency in rats

Cited by 3 publications

References 30 publications

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Genetic and inflammatory factors underlying gestational diabetes mellitus: a review

Marginal Maternal Zinc Deficiency Produces Liver Damage and Altered Zinc Transporter Expression in Offspring Male Rats

Zinc deficiency affects insulin secretion and alters insulin-regulated metabolic signaling in rats

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