The Relationship Between Axons and Schwann Cells During Development of Peripheral Nerves in the Rat

Peters, Alan; Muir, A L

doi:10.1113/expphysiol.1959.sp001366

Cited by 199 publications

(66 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A second possibility is that only the edge of the olfactory nerve receives migrating glia from the olfactory epithelium; the glia in the center of the nerve may derive from actively dividing pro-genitors in the edge region of the nerve. A similar pattern of glial development, i.e., glial cells first found along the edge and later in the center, has been observed in other peripheral nerves (Peters and Muir, 1959).…”

Section: Origin and Development Of Olfactory Nerve Gliasupporting

confidence: 76%

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Norgren

Ratner

Brackenbury

1992

Developmental Dynamics

View full text Add to dashboard Cite

Although there is considerable interest in the possible role of olfactory glia in the pathfinding abilities of olfactory nerve axons, the complete development of these glia in vivo has not been described. Using a specific Schwann cell marker, the 1E8 antibody, we have found that olfactory nerve glia can be identified throughout development. These glia appear to originate in the olfactory placode and migrate initially into the periphery of the olfactory nerve, and later into the center of the nerve. Olfactory nerve glia enter the presumptive olfactory bulb with the olfactory receptor neuron axons and distribute themselves along the edge of the olfactory nerve layer. The fact that olfactory nerve glia are specifically immunostained by the lE8 monoclonal antibody, which recognizes the Schwann cell-specific protein Po, suggests that these cells more closely resemble Schwann cells than astrocytes or enteric glia. These results support and extend previous findings suggesting that olfactory nerve glia have distinctive developmental and anatomical features which may be important to the regenerative capacity of the olfactory system. 0 1992 Wiley-Liss, Inc.

show abstract

Section: Origin and Development Of Olfactory Nerve Gliasupporting

confidence: 76%

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Norgren

Ratner

Brackenbury

1992

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…To achieve the homogeneity seen at adult NMJs, the axon that survives synapse elimination would have to retain one of the sets of Schwann cells, possibly the Schwann cells that associated with it during development. Alternatively, the same founder Schwann cell and its descendants could populate a bundle of axons leading to each junction and separate these axons later in development, in the same way that Schwann cells migrate between and separate axons within developing nerve trunks (Peters and Muir, 1959). Inspection of the data in Figure 4 suggests that Schwann cells are almost as homogeneous at day 6, when half the fibers in the muscle are polyneuronally innervated, as they are in the adult.…”

Section: Variegation In Schwann Cell Labeling At Neuromuscular Junctionsmentioning

confidence: 97%

Fluorescent Proteins Expressed in Mouse Transgenic Lines Mark Subsets of Glia, Neurons, Macrophages, and Dendritic Cells for Vital Examination

Zuo¹,

Lubischer²,

Kang³

et al. 2004

J. Neurosci.

141

158

View full text Add to dashboard Cite

To enable vital observation of glia at the neuromuscular junction, transgenic mice were generated that express proteins of the green fluorescent protein family under control of transcriptional regulatory sequences of the human S100B gene. Terminal Schwann cells were imaged repetitively in living animals of one of the transgenic lines to show that, except for extension and retraction of short processes, the glial coverings of the adult neuromuscular synapse are stable. In other lines, subsets of Schwann cells were labeled. The distribution of label suggests that Schwann cells at individual synapses are clonally related, a finding with implications for how these cells might be sorted during postnatal development. Other labeling patterns, some present in unique lines, included astrocytes, microglia, and subsets of cerebellar Bergmann glia, spinal motor neurons, macrophages, and dendritic cells. We show that lines with labeled macrophages can be used to follow the accumulation of these cells at sites of injury.

show abstract

“…That the tSCs are associated so closely to the nerve terminal arbors might lead one to the conclusion that they extend processes along the nerve terminal branches. This is a reasonable conjecture since these SCs, as apparently all the SCs along the peripheral nerves, appear to arrive at their position by migration along the projecting axons (Peters and Muir, 1959). However, there are numerous instances where tSC have short processes that extend between nerve terminal branches without an accompanying nerve processes, apparently to provide a pathway by which a soma, located on one terminal branch, can extend coverage to an additional terminal branch that has no soma located along it.…”

Section: Schwann Cells At the Neuromuscular Junctionsmentioning

confidence: 99%

Biology and pathology of nonmyelinating Schwann cells

Griffin

Thompson

2008

Glia

251

202

View full text Add to dashboard Cite

The CNS contains relatively few unmyelinated nerve fibers, and thus benefits from the advantages that are conferred by myelination, including faster conduction velocities, lower energy consumption for impulse transmission, and greater stability of point-to-point connectivity. In the PNS many fibers or regions of fibers the Schwann do not form myelin. Examples include C fibers nociceptors, postganglionic sympathetic fibers, and the Schwann cells associated with motor nerve terminals at neuromuscular junctions. These examples retain a degree of plasticity and a capacity to sprout collaterally that is unusual in myelinated fibers. Nonmyelin-forming Schwann cells, including those associated with uninjured fibers, have the capacity to act as the ''first responders'' to injury or disease in their neighborhoods. V V C

show abstract

The Relationship Between Axons and Schwann Cells During Development of Peripheral Nerves in the Rat

Cited by 199 publications

References 10 publications

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Development of olfactory nerve glia defined by a monoclonal antibody specific for schwann cells

Fluorescent Proteins Expressed in Mouse Transgenic Lines Mark Subsets of Glia, Neurons, Macrophages, and Dendritic Cells for Vital Examination

Biology and pathology of nonmyelinating Schwann cells

Contact Info

Product

Resources

About