The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development

Jin, Yunho; Choi, Jeong-Hyun; Won, Jinyoung; Hong, Yonggeun

doi:10.3390/molecules23010198

Cited by 38 publications

(27 citation statements)

References 60 publications

(83 reference statements)

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“…Comorbid conditions may predispose to sleep disturbance, including anxiety, fear, ADHD, sensory attributes, cognitive challenges, repetitive review of activities or anticipation of activity. Children may also have biological and genetic reasons for rapid or slow metabolism of melatonin and dysregulation of the circadian clock . Treatment should be individualised.…”

Section: Sleep Problems and Their Treatment In Specific Disordersmentioning

confidence: 99%

“…Children may also have biological and genetic reasons for rapid or slow metabolism of melatonin and dysregulation of the circadian clock. 17,18 Treatment should be individualised. A recent paper evaluating sensory profiles and sleep disturbance found that hypersensitivity to touch explained 24% of the variance in sleep disturbance in the ASD group, as opposed to other domains such as visual and auditory.…”

Section: Autism Spectrum Disordermentioning

confidence: 99%

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Sleep in children with neurodevelopmental difficulties

Heussler

2018

J Paediatrics Child Health

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Sleep disorders in children with neurodevelopmental disorders are complex and reflect underlying genetic/biological and behavioural components. The sleep disorders are the same as in the typically developing child, although there may be some modifications to the presentation or the frequency depending on the phenotype. Consideration of the known phenotypes and environmental issues are important in defining management strategies. Despite this complexity, defined behavioural strategies with good sleep hygiene can have a significant effect on the sleep problem and on parental management of the behaviours.

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Section: Sleep Problems and Their Treatment In Specific Disordersmentioning

confidence: 99%

Section: Autism Spectrum Disordermentioning

confidence: 99%

Sleep in children with neurodevelopmental difficulties

Heussler

2018

J Paediatrics Child Health

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“…16,25 Melatonin plays a role of circadian rhythm messenger between mother and fetus, which should be involved in the form of normal fetal sleep patterns and circadian rhythms. 18,19 We speculated that the melatonin regulated the circadian rhythms and brought about the associations between maternal sleep and childhood sleep. There has been evidence to support the association of maternal melatonin with children's sleep by longitudinal observation.…”

Section: Discussionmentioning

confidence: 99%

“…17,18 Melatonin, a circadian rhythm messenger linking mother and fetus, has essential functions not only in fetal maturation but also in children's sleep patterns. [18][19][20][21][22][23][24] Because it has been confirmed that sleep disturbance during pregnancy could interfere with the rhythm and amplitude of melatonin secretion, 16,25 we strongly hypothesized that maternal sleep was associated with their offspring's sleep. Two animal studies provided evidence for our hypothesis.…”

Section: Introductionmentioning

confidence: 99%

<p>Children’s Sleep May Depend on Maternal Sleep Duration During Pregnancy: A Retrospective Study</p>

Lyu

Chen

et al. 2020

NSS

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Background: Animal studies suggested that maternal sleep during pregnancy was associated with sleep pattern in offspring; however, it has not been clear in human populations. Aim: Our study discusses the relationships of maternal sleep duration with sleep characteristics in their offspring through an epidemiological study. Methods: A retrospective cross-sectional study including 6236 mother-child dyads was conducted in 31 preschools in May 2019, in Shanghai, China. Information regarding maternal sleep duration in three trimesters of pregnancy was collected retrospectively. Children's current sleep characteristics were evaluated through the Children's Sleep Habits Questionnaire (CSHQ). Linear regressions and logistic regression models were applied to estimate β and adjusted odds ratios with 95% confidence intervals (95% CI). Results: Maternal sleep duration was positively associated with childhood sleep duration, which was shown in the first (β=0.113), second (β=0.131), and third trimesters (β=0.088). Meanwhile, insufficient maternal sleep duration could increase the risk of children's short sleep duration (first trimester: AOR=1.25; second trimester: AOR=1.33; third trimester: AOR=1.33). Maternal sleep duration was also associated with childhood CSHQ score: β= −0.308, −0.392, and −0.300 for the first, second, and third trimesters, respectively. Similarly, insufficient maternal sleep duration could predict childhood sleep disturbance as AOR=1.28 in the second trimester and AOR=1.26 in the third trimester. Conclusion: Our findings established a relationship between maternal sleep during pregnancy and their children's sleep pattern through a population-based epidemiology study. Poor childhood sleep was found when their mother experienced less sleep duration during pregnancy, especially in the second and third trimesters.

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“…Melatonin deficiency might cause abnormal synaptogenesis. Melatonin secretion is often impaired in ASD [19].…”

Section: Melatoninmentioning

confidence: 99%

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

Lee¹

2019

Recent Advances in Biology and Medicine

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Autism spectrum disorder (ASD) is a single spectrum disorder. It is characterized by marked social deficit, stereotype behavior, flexibility, sensory sensitivity, and language impairment. However, ASD can also be accompanied by neuropathology and neuroendocrine dysfunction. Higher testosterone level intrauterine is assumed to increase ASD risk in early childhood. There is limited research about the correlation between ASD and neuroendocrine dysfunction.

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The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development

Cited by 38 publications

References 60 publications

Sleep in children with neurodevelopmental difficulties

Sleep in children with neurodevelopmental difficulties

<p>Children’s Sleep May Depend on Maternal Sleep Duration During Pregnancy: A Retrospective Study</p>

Neuropathology and Neuroendocrine Dysfunction in Autism Spectrum Disorder

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