The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression

Özdemir, Osman; Kurdoğlu, Zehra; Yıldız, Saliha; Özdemir, Pınar Güzel; Yılmaz, Ekrem

doi:10.1016/j.psychres.2016.11.043

Cited by 14 publications

(7 citation statements)

References 40 publications

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“…We thank Carl Gornitzki, librarian at the Karolinska Institutet University Library, Sweden, for developing the search strategy and performing the search. The search identified 33 additional publications related to anxiety and depression in women with PCOS [9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40].…”

Section: Acknowledgmentsmentioning

confidence: 99%

Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

et al. 2019

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Women with polycystic ovary syndrome (PCOS) exhibit compromised psychiatric health. Independent of obesity, women with PCOS are more susceptible to have anxiety and depression diagnoses and other neuropsychiatric disorders. During pregnancy women with PCOS display high circulating androgen levels that may cause prenatal androgen exposure affecting the growing fetus and increasing the risk of mood disorders in offspring. Increasing evidence supports a non-genetic, maternal contribution to the development of PCOS and anxiety disorders in the next generation. Prenatal androgenized rodent models reflecting the anxiety-like phenotype of PCOS in the offspring, found evidence for the altered placenta and androgen receptor function in the amygdala, together with changes in the expression of genes associated with emotional regulation and steroid receptors in the amygdala and hippocampus. These findings defined a previously unknown mechanism that may be critical in understanding how maternal androgen excess can increase the risk of developing anxiety disorders in daughters and partly in sons of PCOS mothers. Maternal obesity is another common feature of PCOS causing an unfavorable intrauterine environment which may contribute to psychiatric problems in the offspring. Whether environmental factors such as prenatal androgen exposure and obesity increase the offspring’s susceptibility to develop psychiatric ill-health will be discussed.

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Section: Acknowledgmentsmentioning

confidence: 99%

Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

et al. 2019

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“…Firstly, gender may be involved as a possible moderator in suicidal behavior; for example, Branco J.C. et al found a statistical relation between obesity and suicide risk in a group of young adult women, but not in men [ 42 ]. Another hypothesis is that glucose homeostasis may cause mental disorders [ 43 , 44 , 45 ], regardless of the body weight; for example, the group of Bendix M. confirmed that higher insulin and lower glucagon plasma levels, are associated with SB [ 46 ]. Hence, we recommend taking into consideration all the clinical and biological factors to understand the nature of SB.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Prevalence of Suicide Attempt in Patients with Type 2 Diabetes in the Mexican Population

Gómez-Peralta

González-Castro

Fresán

et al. 2018

IJERPH

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Background: It has been proposed that the risk of death by suicide is higher in patients with diabetes than in the general population. Therefore, it is necessary to investigate the risk factors of suicidal behavior in patients with type 2 diabetes. The aim of the present study was to analyze the prevalence of suicide attempt and determine the risk factors of suicide attempt, in patients with type 2 diabetes in a Mexican population. Methods: Clinic characteristics, anthropometric measurements, biochemical levels, depression, and suicidal behavior were evaluated in 185 Mexican patients with type 2 diabetes. A multivariate logistic regression analysis was performed to find predictive factors of suicide attempt. Results: 11.4% of patients reported previous suicide attempts n = 21). Younger patients (OR: 3.63, 95% CI: 1.29–10.19), having depression (OR: 3.33, 95% CI: 1.13–9.76) and normal BMI (OR: 3.14, 95% CI: 1.11–8.83), were predictive factors of suicide attempt. No other variables in the study showed statistical significance. Conclusions: Our results showed a high prevalence of suicidal behavior in patients with type 2 diabetes. We found that younger age, depression and normal BMI could be risk factors of suicide attempt in these patients. Therefore, psychiatric interventions to prevent depression and suicidal behavior in this population are necessary. New studies using larger samples are necessary to replicate and confirm these results.

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“…Notably, there appears to be a relationship between insulin resistance and depression [48,49]. In a recent pilot study of adolescent and adult PCOS, Erensoy et al demonstrated that treatment with metformin for 90 days led to reduction in depression and anxiety scores, along with weight and insulin resistance [50], though mechanism of how metformin effects mental health—directly or indirectly—are unknown.…”

Section: Beyond Reproduction: Current Understanding Of Comorbiditimentioning

confidence: 99%

Emerging Topics in Cardiometabolic and Psychologic Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

Shah

2019

Children

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Polycystic ovarian syndrome (PCOS) is a common endocrine disorder, affecting 6–10% of reproductive age women and influences the reproductive, metabolic, dermatologic, and psychiatric health of affected girls and women. Despite its prevalence, the pathogenesis of the disease is largely unknown, and treatment options are limited. Thus, PCOS has been a ripe area for research in recent years, and novel etiologic pathways, diagnostic parameters, and treatment options are being explored. This review focuses on recent data suggesting pathogenic and therapeutic considerations, as well as the psychiatric and metabolic sequelae of PCOS.

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The relationship between atypical depression and insülin resistance in patients with polycystic ovary syndrome and major depression

Cited by 14 publications

References 40 publications

Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

Origins and Impact of Psychological Traits in Polycystic Ovary Syndrome

Risk Factors and Prevalence of Suicide Attempt in Patients with Type 2 Diabetes in the Mexican Population

Emerging Topics in Cardiometabolic and Psychologic Sequelae, Pathogenesis, and Treatment of Polycystic Ovarian Syndrome: A Review

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