The Relationship Between Arterial Elasticity And Metabolic Syndrome Features

Fjeldstad, Anette S.; Acree, Luke S.; Nickel, Kevin; Fjeldstad, Cecilie; Montgomery, Polly S.; Comp, Philip C.; Whitsett, Thomas L.; Gardner, Andrew W.

doi:10.1249/00005768-200505001-01881

Cited by 6 publications

(10 citation statements)

References 7 publications

(8 reference statements)

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“…The present findings are also limited to healthy, non-obese subjects free of cardiovascular disease and cardiovascular risk factors. This rather strict inclusion of subjects was done to better assess the association between age and arterial compliance by minimizing the impact that comorbid conditions have on arterial compliance 18,19…”

Section: Discussionmentioning

confidence: 99%

Association Between Arterial Compliance and Age in Participants 9 to 77 Years Old

Gardner

Parker

2009

Angiology

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We characterized the age-related change in large and small artery compliance in 137 healthy subjects between 9 and 77 years of age. Large artery compliance, measured by diastolic pulse contour analysis, had a sharp positive linear trend (0.89 ml × mmHg−1× year−1) highly correlated with age in subjects younger than 30 years (r = 0.76, p < 0.0001), had a slight negative trend (−0.10 ml × mmHg−1× year−1) not significantly associated with age (r = −0.11, p = 0.532) in middle-aged subjects, and had a sharper negative trend (−0.19 ml × mmHg−1× year−1) significantly associated with age (r = −0.30, p = 0.023) in subjects beyond 50 years. Similar results were found for small artery compliance. Large and small artery compliance increase in children, adolescents, and young adults, reach plateaus near age 30, and then decline beyond 30 years of age in those free of cardiovascular disease and risk factors.

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Section: Discussionmentioning

confidence: 99%

Association Between Arterial Compliance and Age in Participants 9 to 77 Years Old

Gardner

Parker

2009

Angiology

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“…LAEI is determined from the decay in diastolic pressure, and SAEI is determined from the decay in arterial waves reflected from resistance vessels and the microvasculature. (29) Measurements were averaged over three continuous 30-second trials. The test-retest intraclass reliability coefficient is R = 0.87 for large artery compliance and R = 0.83 for small artery compliance.…”

Section: Methodsmentioning

confidence: 99%

Gender and ethnic differences in arterial compliance in patients with intermittent claudication

Gardner

Montgomery

Blevins

et al. 2010

Journal of Vascular Surgery

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Purposes To assess the gender and ethnic differences in arterial compliance in patients with intermittent claudication. Methods A total of 114 patients participated, including 38 Caucasian men, 32 Caucasian women, 16 African-American men, and 28 African-American women. Patients were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), age, weight, body mass index, ankle-brachial index (ABI), smoking status, and metabolic syndrome components. Results Group differences were found for LAEI (p = 0.042), SAEI (p = 0.019), body mass index (p = 0.020), prevalence of elevated fasting glucose (p = 0.001), and prevalence of abdominal obesity (p = 0.025). Significant covariates for LAEI included age (p = 0.0002) and elevated triglycerides (p = 0.0719). LAEI (units = 10 ml × mmHg) adjusted for age and triglycerides was 39% lower (p = 0.0005) in African-Americans (11.4 ± 0.90; mean ± SE) than in Caucasians (15.8 ± 0.72), whereas no significant difference (p = 0.7904) existed between men (13.8 ± 0.81) and women (13.5 ± 0.79). Significant covariates for SAEI included age (p = 0.0001), abdominal obesity (p = 0.0030), and elevated blood pressure (p = 0.0067). SAEI (units = 100 ml × mmHg) adjusted for age, abdominal obesity, and elevated blood pressure was 32% lower (p = 0.0007) in African-Americans (2.8 ± 0.3) than in Caucasians 4.1 ± 0.2), and was 18% lower (p = 0.0442) in women (3.1 ± 0.2) than in men (3.8 ± 0.2). Conclusion African-American patients with intermittent claudication have more impaired macrovacular and microvascular function than Caucasian patients, and women have more impaired microvascular function than men. These ethnic and gender differences in arterial compliance are evident even though ABI was similar among groups, suggesting that arterial compliance provides unique information to quantify vascular impairment in patients with intermittent claudication.

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“…Obesity-related reductions in arterial compliance have been reported in adults [10][11][12] . However, data on arterial compliance in normal or obese children are conflicting; several studies have reported decreased arterial compliance in obese adoles- Insulin levels, μU/ml -3 2 ± 6 3 1 ± 5 HOMA-IR -5.9 ± 1.5 11.6 ± 7.6 ** p < 0.01 vs. lean; † p < 0.01 vs. obese.…”

Section: Discussionmentioning

confidence: 99%

Vascular Compliance in Lean, Obese, and Diabetic Children and Adolescents: A Cross-Sectional Study in a Minority Population

et al. 2014

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Background: In adults, both obesity and type 2 diabetes mellitus (T2DM) are positively correlated with cardiovascular disease mortality and arterial stiffness. Several studies of adults have shown that both obesity and T2DM are independently associated with increased arterial stiffness. However, little is known about the relationship between arterial compliance and cardiovascular disease risk in children. We assessed whether large and small arterial compliance is impaired in obese and diabetic pubertal children. Methods: One hundred children of African-Caribbean ethnicity, aged 14-16 years, including 21 lean children (between the 25th and 75th percentile), 40 obese children (>95th percentile), and 39 children with T2DM diagnosed by American Diabetes Association criteria were studied. Arterial compliance of the large (C 1 ) and small (C 2 ) vessels was measured using radial arterial diastolic pulse wave contour analysis. Results: C 1 did not differ significantly between lean, obese, and T2DM subjects. C 2 was significantly greater in obese and T2DM subjects (10.9 ± 1 and 10.4 ± 0.7 ml/mm Hg × 100 ml, respectively) compared to lean subjects (7.8 ± 0.8 ml/mm Hg × 100 ml; p < 0.05). C 2 was also significantly greater in T2DM subjects receiving antihypertensive drug therapy than in diabetic subjects not on antihypertensive treatment. Conclusion: Increased compliance in diabetic and obese children compared to lean subjects could be secondary to premature maturation of the vascular system; whether this early maturation can translate into a subsequent rise in the incidence of cardiovascular events related to diabetes and obesity can only be determined by long-term follow-up of these patients.

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The Relationship Between Arterial Elasticity And Metabolic Syndrome Features

Cited by 6 publications

References 7 publications

Association Between Arterial Compliance and Age in Participants 9 to 77 Years Old

Association Between Arterial Compliance and Age in Participants 9 to 77 Years Old

Gender and ethnic differences in arterial compliance in patients with intermittent claudication

Vascular Compliance in Lean, Obese, and Diabetic Children and Adolescents: A Cross-Sectional Study in a Minority Population

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