The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6–8 years — the questionnaire study results

Raciborski, Filip; Tomaszewska, Aneta; Komorowski, Jarosław; Samel-Kowalik, Piotr; Białoszewski, Artur; Walkiewicz, Artur; Lusawa, Adam; Szymański, Józef; Opoczyńska, Dagmara; Drużba, Michał; Borowicz, Jacek; Lipiec, Agnieszka; Kapalczynski, Wojciech J.; Samoliński, Bolesław

doi:10.2478/s13382-012-0056-0

Cited by 25 publications

(28 citation statements)

References 23 publications

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“…The main characteristics of the included studies on atopic disorders are summarized in Supplementary Table S1 . There were 20 prospective [ 30 , 50–52 , 57–61 , 63–65 , 69 , 70 , 72 , 74–78 ] and 11 retrospective [ 53–56 , 62 , 67 , 68 , 71 , 73 , 79 ] studies with publication periods ranging from 2005 to 2020 and baseline study periods ranging from 1959 to 2018. The number of participants varied greatly, from 198 [ 61 ] to 792,130 [ 68 ] children.…”

Section: Resultsmentioning

confidence: 99%

The impact of early life antibiotic use on atopic and metabolic disorders

Bejaoui

Poulsen

2020

Evolution, Medicine, and Public Health

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Background and objectives The impact of antibiotics use early in life on later-in-life morbidities has received substantial attention as explanations for atopic and metabolic disorders with a surge as modern lifestyle diseases. The objective of this study was to perform meta-analyses to determine if antibiotics administration during the first two years of infant life is associated with increased risks of atopic or metabolic disorders later in life. Methodology We screened more than 100 English-language prospective and retrospective studies published between January 2002 and March 2020 and assessed study quality using the Newcastle–Ottawa scale. We performed overall and subgroup meta-analyses on 31 high-quality comparable studies on atopic and 23 on metabolic disorders, involving more than 3.5 million children. Results Antibiotic exposure prenatally and during the first two years of life significantly impacts the risk of developing atopic and metabolic disorders. Exposure during the first six months of life appears most critical, consistent with this being the time when the microbiome is most susceptible to irreversible perturbations. The presence of dose-response associations and stronger impacts of broad- than narrow-spectrum antibiotics further point to effects being mediated by microbiota-induced changes. Conclusions and implications Our findings support that antibiotics use is a mismatch to modernity that can negatively affect the symbiotic associations we rely on for proper immune function and metabolism. Improving our understanding of these associations, the underlying proximate mechanisms, and the impact of antibiotics use on future human-symbiont evolution will be important to improve human health. Abstract The use of antibiotics in infancy has been suggested to increase the risks of atopic and metabolic disorders later in life. Through meta-analyses of more than 100 studies (>3.5mio children), we confirm these risks, and the observed patterns are consistent with this being due to microbiota-driven changes.

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Section: Resultsmentioning

confidence: 99%

The impact of early life antibiotic use on atopic and metabolic disorders

Bejaoui

Poulsen

2020

Evolution, Medicine, and Public Health

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“…3,4 A host of additional studies established that in addition to the findings noted above, absence of early antibiotic exposure, exclusive breast-feeding for the first 4 months of life, vaginal delivery, furry pets in the home during infancy, lack of maternal antibiotic use during pregnancy, and maternal animal exposure during pregnancy all were associated with lower rates of allergic disease. 5-9 Taken together, these clinical observations established a strong link between microbes and the development of allergic disease.…”

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confidence: 84%

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Huang

Marsland

Bunyavanich

et al. 2017

Journal of Allergy and Clinical Immunology

289

270

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PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.

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“…Although the intestinal microbial community does not stabilize in humans until about 3 years of age Yatsunenko et al, 2012), the precise age of the critical window in infants is not yet clear. Antibiotic use during the prenatal period or the first years of life is associated with an increased risk of asthma, allergic disease, and atopic dermatitis (Marra et al, 2009;Martel et al, 2009;Murk et al, 2011;Raciborski et al, 2012;Risnes et al, 2011;Stensballe et al, 2013). The microbiome is also implicated in susceptibility to T1D (for a review, see Paun et al, 2017).…”

Section: Relevance For Disease Susceptibility Later In Lifementioning

confidence: 99%

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

2017

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The intestinal immune system has the daunting task of protecting us from pathogenic insults while limiting inflammatory responses against the resident commensal microbiota and providing tolerance to food antigens. This role is particularly impressive when one considers the vast mucosal surface and changing landscape that the intestinal immune system must monitor. In this review, we highlight regional differences in the development and composition of the adaptive immune landscape of the intestine and the impact of local intrinsic and environmental factors that shape this process. To conclude, we review the evidence for a critical window of opportunity for early-life exposures that affect immune development and alter disease susceptibility later in life.

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The relationship between antibiotic therapy in early childhood and the symptoms of allergy in children aged 6–8 years — the questionnaire study results

Abstract: There is a direct relationship between antibiotic use in the first 3 years of life and asthma and allergy symptoms in children aged 6-8 years old.

Cited by 25 publications

References 23 publications

The impact of early life antibiotic use on atopic and metabolic disorders

The impact of early life antibiotic use on atopic and metabolic disorders

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

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