The Relationship between Androgens, Regulators of Collagen Metabolism, and Peyronie’s Disease: A Case Control Study

Karavitakis, Markos; Komninos, Christos; Simaioforidis, Vasileios; Kontos, Stylianos; Lefakis, George; Politis, V.; Koritsiadis, George; Konstantellou, Katerina; Doumanis, Gregorios

doi:10.1111/j.1743-6109.2010.01915.x

Cited by 22 publications

(13 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Androgens have been implicated to contribute to PD severity at the cellular level through the mediation of remodeling of tissue in the tunica albuginea of the penis and the process of collagen organization and deposition [9]. Hypogonadism may contribute to the development of PD through its impact on erection rigidity.…”

Section: Discussionmentioning

confidence: 99%

“…Well accepted as a wound‐healing disorder, it has been hypothesized that comorbidities known to impair the wound healing process may play a role in the progression or severity of PD. Symptomatic hypogonadism and biochemical low testosterone (T) levels independently represent particular comorbidities of interest, as recent studies have shown that androgens directly influence collagen metabolism and the process of scar formation—key steps in the pathogenesis of PD [8–10]. These findings have dovetailed well with retrospective data illustrating a 74.4% incidence of hypogonadism among patients with PD [11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Low Testosterone Has a Similar Prevalence among Men with Sexual Dysfunction Due to Either Peyronie's Disease or Erectile Dysfunction and Does Not Correlate with Peyronie's Disease Severity

Kirby¹,

Verges²,

Matthews³

et al. 2015

The Journal of Sexual Medicine

View full text Add to dashboard Cite

Introduction Low testosterone (T) has been suggested as a risk factor for Peyronie's disease (PD) that may correlate with disease severity. Low T is common in men with sexual dysfunction but its role in the pathogenesis of PD remains unclear. Aim The aim of this study was to compare the prevalence of low T (<300 ng/dL) in patients presenting with PD or erectile dysfunction (ED), as well as disease severity between men with PD and either low T or normal T (≥300 ng/dL). Methods Retrospective review of 300 men with either PD or ED was conducted. Men were excluded for combined PD and ED, psychogenic ED, or prior T use. For men with PD, plaque size, degree of curvature, and surgical correction rate were compared. Main Outcome Measures The main outcome measures were (i) mean T levels in men with PD or ED and (ii) plaque size, degree of curvature, and surgical correction rates among men with PD and either low T or normal T. Results Eighty-seven men with PD and 98 men with ED were identified. Men with PD had mean total T and free T of 328 ng/dL and 11.5 ng/dL, while men with ED had mean levels of 332 ng/dL and 12.1 ng/dL, respectively (P > 0.05). Of PD men, 52.9% had low T, compared with 45.9% of men with ED (P = 0.35). T levels did not correlate with plaque size or degree of curvature in the PD group (P > 0.05). Conclusions Men with sexual dysfunction characterized by either PD or ED had similarly low T levels, and low T did not correlate with PD severity or surgical correction rate. The comparable prevalence of low T in men with PD or ED suggests the high rate of low T in PD men may be related to a common process among men with abnormal erectile physiology and not specifically causative in plaque formation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low Testosterone Has a Similar Prevalence among Men with Sexual Dysfunction Due to Either Peyronie's Disease or Erectile Dysfunction and Does Not Correlate with Peyronie's Disease Severity

Kirby¹,

Verges²,

Matthews³

et al. 2015

The Journal of Sexual Medicine

View full text Add to dashboard Cite

show abstract

“…21 In contrast, yet another study failed to show a difference between T levels in men with PD compared to controls, although the study was small and likely underpowered. 22 Interestingly, significantly lower adrenal androgen levels in the PD group compared to controls were observed, leading to a hypothesis that hypogonadism or androgen deficiency may play a role in PD pathogenesis because androgens modulate matrix metalloproteinases that are important in normal wound healing. If these androgens are deficient, the risk of PD increases.…”

Section: Etiology and Modifiable Risk Factorsmentioning

confidence: 99%

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

Bilgutay

Pastuszak

2015

Curr Sex Health Rep

View full text Add to dashboard Cite

Peyronie’s Disease (PD) is a superficial fibrosing disorder of the penis resulting in plaque formation and penile deformity. Once considered rare, PD has more recently been found in up to 13% of men, and can negatively affect sexual and psychosocial function of both patients and their partners. While the etiology of PD is unclear, it is thought to result from an inciting traumatic event followed by aberrant fibrosis or dysregulated wound healing. The evaluation of men presenting with PD includes a detailed history and physical exam, focusing on the penis in both the flaccid and erect states. PD is often associated with erectile dysfunction (ED), as well as several other comorbidities. Laboratory testing is not needed to diagnose PD, although given the associations between PD and systemic diseases including hypogonadism, diabetes, and cardiovascular disease, screening and work-up for these conditions in men with PD may be warranted. Treatment modalities for PD are diverse and include oral, topical, intralesional, mechanical, and surgical therapies. Oral, topical, and mechanical therapies generally have little evidence supporting their efficacy. Several intralesional therapies, including interferon α2b and collagenase Clostridium hystiolyticum have demonstrated efficacy in the treatment of PD. Surgical treatment, indicated in men with significant, stable deformity, includes plication of the tunica albuginea, plaque incision/excision and grafting, and placement of inflatable penile prosthesis (IPP) with or without additional maneuvers to achieve desired results, and has high success rates.

show abstract

“…Nitric oxide (NO) acts as an antifibrotic factor, and an increase in the level of NO decreases excess collagen formation during wound healing [12], whereas matrix metalloproteinases are the molecules responsible for collagen degradation. In PD patients, there is a decreased level of matrix metalloproteinases and increased level of its tissue inhibitors adding to the excess fibrosis [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

Roaiah¹,

Hassanin²,

Aal³

et al. 2015

Human Andrology

View full text Add to dashboard Cite

PurposeBoth Peyronie's disease (PD) and late onset hypogonadism occur, most likely, in middle-aged and old men. It is well-known that testosterone declines with age and is implicated in wound healing; therefore, the role of testosterone deficiency in the development and severity of PD was investigated. Patients and methods A prospective controlled study was carried out on 25 participants, 15 with PD and 10 controls. PD patient history questionnaire was obtained, and PD was later confirmed by physical examination. The total and free serum testosterone levels were estimated. Evaluation of the differences between the two groups was carried out. In PD patients, the plaque area and penile curvature were assessed. PD patients were further classified into two subgroups: subgroup A (low testosterone level) and subgroup B (normal testosterone level). Evaluation of the differences between the two subgroups, such as the plaque area and penile curvature, was carried out. ResultsA significantly lower free and total serum testosterone levels were found in the PD patient group compared with the control group (Po0.05). Moreover, it was found that 60% of patients with PD had low serum testosterone levels. On comparing the subgroups, the plaque size was found to be significantly larger and the mean degree of penile curvature was found to be significantly greater in subgroup A. ConclusionTestosterone deficiency may play a role in the development of PD and in the development of more severe manifestations of the disease, such as plaque size and penile curvature. However, further studies with larger samples are encouraged to confirm these conclusions.

show abstract

The Relationship between Androgens, Regulators of Collagen Metabolism, and Peyronie’s Disease: A Case Control Study

Cited by 22 publications

References 45 publications

Low Testosterone Has a Similar Prevalence among Men with Sexual Dysfunction Due to Either Peyronie's Disease or Erectile Dysfunction and Does Not Correlate with Peyronie's Disease Severity

Low Testosterone Has a Similar Prevalence among Men with Sexual Dysfunction Due to Either Peyronie's Disease or Erectile Dysfunction and Does Not Correlate with Peyronie's Disease Severity

Peyronie’s Disease: A Review of Etiology, Diagnosis, and Management

The role of testosterone deficiency in the development of Peyronie’s disease and its role in the severity of the disease manifestations

Contact Info

Product

Resources

About