The relationship between an endangered North American tree and an endophytic fungus

Lee, Julie C.; Yang, Xianshu; Schwartz, Mark W.; Strobel, Gary A.; Clardy, Jon

doi:10.1016/1074-5521(95)90100-0

Cited by 81 publications

(50 citation statements)

References 12 publications

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“…Its UV spectrum with maximum absorption bands at λ max 213, 226, 251 and 320 nm indicated that 1 had a conjugated pyrone chromophore (Lee et al, 1995). The IR spectrum showed absorption bands at 3394 and 1714 cm -1 for hydroxyl and conjugated carbonyl groups, respectively.…”

Section: Resultsmentioning

confidence: 98%

Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22

et al. 2011

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Investigation of secondary metabolites from the sea fan-derived fungus Curvularia sp. PSU-F22 resulted in isolation of three new metabolites, curvulapyrone (1), curvulalide (2) and curvulalic acid (3) together with six known compounds, modiolides A (4) and B (5), pyrenolide A (6), stagonolide E (7), mycoepoxydiene (8), and deacetylmycoepoxydiene (9). Their antimicrobial activity against Staphylococcus aureus ATCC 25923, methicillin-resistant S. aureus and Microsporum gypseum SH-MU-4 were examined.

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Section: Resultsmentioning

confidence: 98%

Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22

et al. 2011

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“…Scientists all over the world have studied taxol production on various platforms including chemical synthesis, plant cell and tissue culture (Table 1) (Fett-Neto et al 1992;Wang and Zhong 2002;Wang et al 2007a, b, c;Khosroushahi et al 2006;Croteau et al 2006), endophytic fungi (reviewed by Visalakshi and Muthumary 2010), microbial fermentation, and so on (Jennewein and Croteau 2001;Frense 2007). Zhou et al (2010) reviewed that microbial fermentation of endophytic fungi is a new and feasible approach to the production of taxol (Stierle et al 1993;Lee et al 1995;Li et al 1996;Huang et al 2001;Wang et al 2000;Sun et al 2008). …”

Section: Taxolmentioning

confidence: 98%

Endophytic fungi: novel sources of anticancer lead molecules

Chandra

2012

Appl Microbiol Biotechnol

220

120

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Cancer is a major killer disease all over the world and more than six million new cases are reported every year. Nature is an attractive source of new therapeutic compounds, as a tremendous chemical diversity is found in millions of species of plants, animals, and microorganisms. Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer agents. These include vinblastine, vincristine, camptothecin, podophyllotoxin, and taxol. Production of a plant-based natural drug is always not up to the desired level. It is produced at a specific developmental stage or under specific environmental condition, stress, or nutrient availability; the plants may be very slow growing taking several years to attain a suitable growth phase for product accumulation and extraction. Considering the limitations associated with the productivity and vulnerability of plant species as sources of novel metabolites, microorganisms serve as the ultimate, readily renewable, and inexhaustible source of novel structures bearing pharmaceutical potential. Endophytes, the microorganisms that reside in the tissues of living plants, are relatively unstudied and offer potential sources of novel natural products for exploitation in medicine, agriculture and the pharmaceutical industry. They develop special mechanisms to penetrate inside the host tissue, residing in mutualistic association and their biotransformation abilities opens a new platform for synthesis of novel secondary metabolites. They produce metabolites to compete with the epiphytes and also with the plant pathogens to maintain a critical balance between fungal virulence and plant defense. It is therefore necessary that the relationship between the plants and endophytes during the accumulation of these secondary metabolites is studied. Insights from such research would provide alternative methods of natural product drug discovery which could be reliable, economical, and environmentally safe.

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“…Thus, endophytes may play an important role in their host's growth and the formation of secondary metabolites related to plant defense. However, existing research into these relationships mainly concentrates on ecological associations (Lee et al 1995). There have been no reports of application of endophyte-plant associations based on natural ecosystems in paclitaxel production.…”

Section: Introductionmentioning

confidence: 99%

Effects of paclitaxel-producing fungal endophytes on growth and paclitaxel formation of Taxus cuspidata cells

Tao

2009

Plant Growth Regul

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Effects of a fungal endophyte, Fusarium mairei, on growth and paclitaxel formation of Taxus cuspidata cells were investigated by adding fungal endophyte culture supernatant (FECS) to suspension cultures of T. cuspidata cells. The main effective chemical responsible for paclitaxel formation in FECS was an exopolysaccharide (EPS) of molecular weight *2 kDa. FECS fractions except EPS stimulated growth of Taxus cells but had no effects on paclitaxel accumulation. Additionally, elicitation efficiency of FECS based on different culture conditions was studied. EPS content in FECS was related to FECS culture conditions. FECS with long cultivation and high-aeration cultivation contained higher EPS content and resulted in higher paclitaxel yield than that with short cultivation and low-aeration cultivation. The maximum yield of paclitaxel from Taxus cultures, elicited by FECS with 9-day cultivation, was 4.7-fold that of the control cultures.

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The relationship between an endangered North American tree and an endophytic fungus

Cited by 81 publications

References 12 publications

Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22

Modiolide and pyrone derivatives from the sea fan-derived fungus Curvularia sp. PSU-F22

Endophytic fungi: novel sources of anticancer lead molecules

Effects of paclitaxel-producing fungal endophytes on growth and paclitaxel formation of Taxus cuspidata cells

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