The relationship between alexithymia, reading the mind in the eyes and cognition in patients with multiple sclerosis

Seren, Burcu Karpuz; Ateş, Mustafa; Cinar, Bilge Piri; Demirel, Esra; Celebi, Ulufer; Atasoy, H. Tuğrul

doi:10.1016/j.msard.2022.104196

Cited by 4 publications

(4 citation statements)

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“…Conversely, in another study, Bodini et al (2008) reported a lower prevalence of 13.8% in Italian patients with MS (Bodini et al, 2008). Recent studies conducted with Turkish populations have found that the rate of alexithymia in MS patients can range from 24.2% to 40.8% (e.g., (Seren et al, 2022;Yilmaz et al, 2023). In the present study, the wide range in the prevalence of alexithymia may have prevented us from finding a significant difference in MentS-S. As discussed in the literature, these discrepancies could be attributed to differences in the clinical characteristics of the samples, cultural differences, or other unknown factors (Chahraoui et al, 2014).…”

Section: Discussionmentioning

confidence: 92%

“…(2008) reported a lower prevalence of 13.8% in Italian patients with MS (Bodini et al., 2008). Recent studies conducted with Turkish populations have found that the rate of alexithymia in MS patients can range from 24.2% to 40.8% (e.g., (Seren et al., 2022; Yilmaz et al., 2023). In the present study, the wide range in the prevalence of alexithymia may have prevented us from finding a significant difference in MentS‐S.…”

Section: Discussionmentioning

confidence: 99%

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Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

Kuzu Kumcu,

Törenli Kaya,

Hoşgören Alıcı

2024

Brain and Behavior

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BackgroundMentalization can be defined as a mental process by which an individual directly or indirectly perceives and interprets one's own and others' behavior, emotions, beliefs, and needs based on designed mental states. Mentalization problems may be linked to remove associative white matter fiber disconnection. Multiple sclerosis (MS) is one of the diseases with white matter lesions. By comparing MS patients with healthy controls, it was aimed to assess whether MS patients' mentalization skills are affected.MethodThis study involved 243 participants (170 healthy controls and 73 patients with MS). All the participants completed a sociodemographic questionnaire and the Mentalization Scale (MentS).ResultsWhile it was discovered that MentS scores for the dimension of others‐based mentalization (MentS‐O) were statistically lower in MS group, there was no statistically significant difference between the groups in terms of the dimensions of motivation to mentalize (MentS‐M) and self‐based mentalization (MentS‐S) scores.ConclusionWe may conclude that MS patients have trouble comprehending other people's thoughts. This effect can be one of the causes of MS patients' issues with social cognition.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

Kuzu Kumcu,

Törenli Kaya,

Hoşgören Alıcı

2024

Brain and Behavior

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“…Individuals with alexithymia exhibit impaired neurocognitive performance, particularly in working memory and executive function (Correro et al, 2021; Vermeulen, 2021). Deficiencies in social cognition, including theory of mind and empathy, are also observed in alexithymia (Karpuz Seren et al, 2022; Rösch et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Alexithymia in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates, and relationship with neurocognition and empathy

Peng,

Wang,

Wang

et al. 2023

Asia-Pacific Psychiatry

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IntroductionAlexithymia is highly prevalent and strongly related to adverse consequences in patients with schizophrenia. However, its associated factors remain largely unexplored. The present study aimed to determine the prevalence of alexithymia and its association with sociocultural characteristics, clinical symptoms, neurocognition, and empathy in 854 Chinese patients with schizophrenia.MethodDemographic information was collected through a self‐designed questionnaire. Alexithymia was assessed by the Toronto Alexithymia Scale (TAS‐20). We assessed clinical symptoms, neurocognition, and empathy via the following instruments: Positive and Negative Syndrome Scale, Repeatable Battery for the Assessment of Neuropsychological Status, and Interpersonal Reactivity Index. A multiple logistic regression model was conducted to determine the independent correlates of alexithymia.ResultsApproximately one‐third (n = 277, 32%) of patients with schizophrenia had alexithymia. Patients with alexithymia had significantly more severe negative symptoms, neurocognition, and empathy impairment than patients without alexithymia. Being male, negative symptoms, personal distress, empathic concern, and language functioning were independently associated with alexithymia.DiscussionOur findings demonstrate a high prevalence of alexithymia and its strong association with clinical symptoms, neurocognition, and empathy, which calls for timely screening and intervention for alexithymia in patients with schizophrenia. Targeting impaired language function, negative symptoms, and impaired affective empathy might help reduce alexithymia and its related negative consequences.

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“…Impaired theory of mind is related to a reduced perspective taking ability, which could have consequences for optimal social functioning (Bruno et al, 2022). Similarly, PwMS are more likely to have problems with feeling their emotions (alexithymia) than healthy controls, making it difficult for them to recognize emotions in themselves and those around them, leading to reduced empathy (Karpuz Seren et al, 2022).…”

Section: Social Cognition and Human Modelsmentioning

confidence: 99%

Social Cognition in Individuals with Multiple Sclerosis and Co-morbid Diabetes: The Role of Metformin and the Biomarker Monoacylglycerol Lipase

Ramani¹

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Multiple sclerosis (MS) can be associated with social cognition deficits. Metformin, a drug used to treat type II diabetes mellitus (DMII) improves social cognition in mice by repressing monoacylglycerol lipase (MgII) in the brain. Social cognition was compared in people with MS (PwMS) and comorbid DMII who are and who are not treated with metformin. We recruited 22 individuals with MS and DMII, and 17 matched healthy controls to establish baseline levels of the outcome measures. Differences were assessed in social cognitive outcomes and MgII levels between metformin and nonmetformin, and healthy control groups. Mgll levels were lowest in the metformin group, although differences were not statistically significant. There were no social cognition differences between the metformin and nonmetformin groups, but the MS group overall performed worse than controls on certain social cognition domains. Implications of these results are reported, with suggestions for future social cognition and MS investigations.

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The relationship between alexithymia, reading the mind in the eyes and cognition in patients with multiple sclerosis

Cited by 4 publications

References 45 publications

Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

Mentalizing self mind but not others: Self‐reported mentalization difficulties in multiple sclerosis

Alexithymia in Chinese patients with chronic schizophrenia: Prevalence, clinical correlates, and relationship with neurocognition and empathy

Social Cognition in Individuals with Multiple Sclerosis and Co-morbid Diabetes: The Role of Metformin and the Biomarker Monoacylglycerol Lipase

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