The Relationship between Alexithymia and Mental Health Is Fully Mediated by Anxiety and Depression in Patients with Psoriasis

Quinto, Rossella Mattea; Vincenzo, Francesco De; Graceffa, Dario; Bonifati, C.; Innamorati, Marco; Iani, Luca

doi:10.3390/ijerph19063649

Cited by 18 publications

(11 citation statements)

References 49 publications

(76 reference statements)

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“…The HADS was used to evaluate the overall mood, which has the advantage of assessing depression and anxiety using the same metric. 18,30 We investigated the potential link between the numbers of AEs or involved systems/ tissues and the HADS-Anxiety and HADS-Depression scores via the use of linear regression models. Although there were no significant changes in the HADS scores after acitretin treatment, the treatment-related AEs had some effects on psychological aspects such as anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

Impact of Adverse Events Associated With Acitretin Treatment of Moderate-to-Severe Plaque Psoriasis: Based on an Observational, Single-Center Study in Shanghai, China

Zhong,

Li,

et al. 2023

International Journal of Dermatology and Venereology

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Objective: Acitretin is a widely used systemic retinoid that is to treat psoriasis but has significant variations in efficacy and adverse events (AEs) among individuals. This study aimed to determine the impact of AEs associated with acitretin treatment of moderate-to-severe plaque psoriasis on the Dermatology Life Quality Index (DLQI) and Hospital Anxiety and Depression Scale (HADS) scores. Methods: This prospective, observational, single-center study was conducted from March 2021 to June 2022 and analyzed 116 patients with moderate-to-severe plaque psoriasis treated with acitretin who were followed up for 12 weeks. The primary outcome was the incidence of AEs related to acitretin, and the secondary objective was to investigate the effect of AEs on the DLQI and HADS scores. The generalized linear models were used to assess the association between AEs related to acitretin and DLQI scores or HADS scores, and the association between the involved system/tissue and DLQI scores or HADS scores. Results: A final total of 45 patients were included in the analysis, and a total of 157 treatment-related AEs involving nine organs or systems were reported in 41 patients. The most common AE was skin- or mucosa-related, with 72 cumulative events in 31 patients. AEs also commonly affected the endocrine, digestive, and genitourinary systems. Compared with the group with 0–2 AEs, the group with 3–5 AEs had a significantly increased DLQI score by 5.49 points (95% CI, 1.47–9.51) (P = 0.0089). Compared with AEs involving 0 to 1 system, AEs affecting 2 to 3 systems resulted in a significant increase in the DLQI score by 5.75 points (95% CI, 1.67–9.83) (P = 0.0071). Generalized linear models showed no statistically significant associations between AEs and the HADS scores. Conclusion: Our study demonstrates a high incidence of acitretin-related AEs. These AEs may affect quality of life but rarely cause psychological problems such as anxiety and depression.

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Section: Discussionmentioning

confidence: 99%

Impact of Adverse Events Associated With Acitretin Treatment of Moderate-to-Severe Plaque Psoriasis: Based on an Observational, Single-Center Study in Shanghai, China

Zhong,

Li,

et al. 2023

International Journal of Dermatology and Venereology

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“…Several articles found that one's emotional or psychological state contributed to mental health conditions (52,119,(129)(130)(131)(132)(133). Positive feelings such as hope, optimism, and self-efficacy were generally associated with better mental health status than helplessness, pessimism, worry/fear, distress, and anxiety (129,131,134,135).…”

Section: (Which Was Not Certified By Peer Review) Preprintmentioning

confidence: 99%

The Impact of COVID-19 Pandemic on Mental Health: A Scoping Review

Josiah

Ncube

2022

Preprint

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Background This scoping review assessed the COVID-19 impacts on mental health and associated risk factors. Methods A systematic literature search for relevant articles published in the period March 2020 to July 2022, was conducted in the APA PsychInfo, JBI Evidence Synthesis, Epistemonikos, PubMed, and Cochrane databases. Results A total of 72 studies met the inclusion criteria. Results showed that the commonly used mental health assessment tools were the Patient Health Questionnaire (41.7%), Generalized Anxiety Disorder Scale (36%), 21-item Depression, Anxiety, and Stress (13.9%), Impact of Event Scale (12.5%), Pittsburgh Sleep Quality Index (9.7%), Symptom Checklist and the General Health Questionnaire (6.9% each). The prevalence rate of depression ranged from 5-76.5%, 5.6-80.5% for anxiety, 9.1-65% for Post-Traumatic Stress Disorder, 8.3-61.7% for sleep disorders, 4.9-70.1% for stress, 7-71.5% for psychological distress, and 21.4-69.3% for general mental health conditions. The major risks included female gender, healthcare-related/frontline jobs, isolation/quarantine, poverty, lower education, COVID-19 risk, age, commodities, mental illness history, negative psychology, and higher social media exposure. The incidence of mental disorders increased along with the increasing cases of COVID-19 and the corresponding government restrictions. Conclusion Standard assessment tools were used for mental health assessment by the reviewed studies which were conducted during COVID-19. Mental health disorders like depression, anxiety, and stress increased during the COVID-19 pandemic and lockdowns. Various factors impacted the prevalence of mental health disorders. Policymakers need to provide social protective measures to improve coping capacities during critical health events to avoid negative impacts on the population. Further studies should investigate the effectiveness of interventions for reducing the prevalence and risk factors for mental health conditions during a public health challenge.

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“…Psoriasis has been considered one of the most stress-related skin diseases, and its onset or recurrence is connected with stress markers (Cannavò et al, 2019;Hunter et al, 2013) and the relationship between stress and the exacerbation of the symptoms (Rousset & Halioua, 2018). Psoriasis has been related to a more significant presence of alexithymic traits (Quinto et al, 2022), sympto-matology related to higher levels of stress (Baker et al, 2013), and has been associated with depression (Pietrzak et al, 2017), anxiety (Fleming et al, 2017), and suicidal ideation (Cohen et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A Pilot of Brief Mindfulness-Based Intervention to manage emotions in patients with psoriasis

et al. 2023

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Psoriasis is a high incidence dermatosis related to stress, and its sufferers provide an appropriate target group to carry out interventions such as those based on mindfulness, aimed at helping emotion regulation. To assess the Compassionate Emotional Accompaniment Technique (CEAT) effects within a brief mindfulness-based intervention on emotional coping in patients with severe psoriasis to determine the efficacy of emotional coping after the induction of a negative emotional state. Forty-four adults (59.1% were women) aged 22-71 years (M = 51.95, SD = 11.87) with severe psoriasis were assigned randomly to the CEAT group or the Emotional Disclosure control group. Subjective discomfort, cognitive ability, affect, and heart rate were assessed before and after the interventions, with two follow-ups at 48 hours and seven days. The results show significant statistical differences in favor of the CEAT intervention versus the Emotional Disclosure group, being more effective in the emotional management after induction and follow-up. These results encourage interventions in a clinical setting with patients with severe psoriasis, so future research should consider using this intervention type to improve emotional management with this population group. La psoriasis es una dermatosis de alta incidencia relacionada con el estrés, constituyendo las personas que lo padecen, un grupo objetivo adecuado para llevar a cabo intervenciones basadas en mindfulness, destinadas a ayudar a la regulación de las emociones. El objetivo del presente estudio es evaluar los efectos de la Técnica de Acompañamiento Emocional Compasivo (CEAT), como una intervención breve basada en mindfulness, sobre el afrontamiento emocional en pacientes con psoriasis grave, para determinar la eficacia del afrontamiento emocional tras la inducción de un estado emocional negativo. Cuarenta y cuatro adultos (el 59,1% mujeres) con edades comprendidas entre los 22 y los 71 años (M = 51,95, DT = 11,87), con psoriasis grave, fueron asignados aleatoriamente a un grupo de intervención con CEAT o a un grupo control de intervención de Revelación Emocional. Se evaluaron malestar subjetivo, capacidad cognitiva, afecto y frecuencia cardíaca, antes y después de las intervenciones, con dos seguimientos a las 48 horas y a los siete días. Los resultados muestran diferencias estadísticas significativas a favor de la intervención CEAT frente al grupo de Revelación Emocional, siendo más eficaz en el manejo emocional tras la inducción y el seguimiento. Estos resultados podrían favorecer la intervención en entornos clínicos con pacientes con psoriasis grave, y futuras investigaciones podrían considerar el uso de esta para mejorar la gestión emocional en este tipo de población

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The Relationship between Alexithymia and Mental Health Is Fully Mediated by Anxiety and Depression in Patients with Psoriasis

Cited by 18 publications

References 49 publications

Impact of Adverse Events Associated With Acitretin Treatment of Moderate-to-Severe Plaque Psoriasis: Based on an Observational, Single-Center Study in Shanghai, China

Impact of Adverse Events Associated With Acitretin Treatment of Moderate-to-Severe Plaque Psoriasis: Based on an Observational, Single-Center Study in Shanghai, China

The Impact of COVID-19 Pandemic on Mental Health: A Scoping Review

A Pilot of Brief Mindfulness-Based Intervention to manage emotions in patients with psoriasis

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