The Relationship between Airway Inflammation and Exacerbation in Chronic Obstructive Pulmonary Disease

Perng, Diahn Warng; Chen, Pei Ku

doi:10.4046/trd.2017.0085

Cited by 20 publications

(8 citation statements)

References 99 publications

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“…Scientific evidences support that short- and long-term exposures to ambient air pollutants are associated with a broad of adverse health outcomes ( Ferrante and Conti, 2017 ; Fiore et al, 2019 ), such as higher mortality rates, greater hospital admissions and increased outpatient visits ( Bremner et al, 1999 ; Cohen et al, 2017 ; Dehghani et al, 2017 ; Dockery et al, 1993 ). It has markedly detrimental consequences on asthma, bronchitis, pneumonia and COPD ( Dick et al, 2014 ; Perng and Chen, 2017 ; Raji et al, 2020 ; Vignal et al, 2017 ; Yarahmadi et al, 2018 ), where bacteria and viruses are the most accepted causative factors that harm airway stability, driving to infection exacerbation. Furthermore, air pollution represents an aggravating factor for infection diseases caused by some viral infections ( Domingo and Rovira, 2020 ), such as respiratory syncytial virus (RSV), influenza A and B, para influenza virus type 3, pneumonia and influenza-like illness ( Carugno et al, 2018 ; Croft et al, 2020 ; Fukuda et al, 2011 ; Huang et al, 2016 ; Huh et al, 2020 ; Liang et al, 2014 ; Lin et al, 2005 ; Silva et al, 2014 ; Somayaji et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Copat

Cristaldi

Fiore

et al. 2020

Environmental Research

321

240

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A new coronavirus (SARS-CoV-2) has determined a pneumonia outbreak in China (Wuhan, Hubei Province) in December 2019, called COVID-19 disease. In addition to the person-to person transmission dynamic of the novel respiratory virus, it has been recently studied the role of environmental factors in accelerate SARS-CoV-2 spread and its lethality. The time being, air pollution has been identified as the largest environmental cause of disease and premature death in the world. It affects body's immunity, making people more vulnerable to pathogens. The hypothesis that air pollution, resulting from a combination of factors such as meteorological data, level of industrialization as well as regional topography, can acts both as a carrier of the infection and as a worsening factor of the health impact of COVID-19 disease, has been raised recently. With this review, we want to provide an update state of art relating the role of air pollution, in particular PM 2.5 , PM 10 and NO 2 , in COVID-19 spread and lethality. The Authors, who first investigated this association, often used different research methods or not all include confounding factors whenever possible. In addition, to date incidence data are underestimated in all countries and to a lesser extent also mortality data. For this reason, the cases included in the reviewed studies cannot be considered conclusive. Although it determines important limitations for direct comparison of results, and more studies are needed to strengthen scientific evidences and support firm conclusions, major findings are consistent, highlighting the important contribution of PM 2.5 and NO 2 as triggering of the COVID-19 spread and lethality, and with a less extent also PM 10 , although the potential effect of airborne virus exposure it has not been still demonstrated.

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Section: Introductionmentioning

confidence: 99%

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Copat

Cristaldi

Fiore

et al. 2020

Environmental Research

321

240

View full text Add to dashboard Cite

show abstract

“…In patients with acute exacerbations of obstructive lung disease, the inflammatory cascade results in the release of proinflammatory molecules, such as cytokines and interleukins, mediated by neutrophils, macrophages, and lymphocytes. 17 , 18 The sympathetic responses to hypoxia and hypercapnia, in addition to the exacerbation through peripheral chemoreceptors, further enhance the overall catecholaminergic drive. 19 In a proinflammatory state, this robust catecholaminergic response may provide the foundation for the development of TTS.…”

Section: Resultsmentioning

confidence: 99%

Takotsubo syndrome and respiratory diseases: a systematic review

Wang

Liang

et al. 2022

European Heart Journal Open

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Aims Takotsubo syndrome (TTS) is a rare cardiovascular condition characterized by reversible ventricular dysfunction and a presentation resembling that of acute myocardial infarction. An increasing number of studies has shown the association of respiratory diseases with TTS. Here, we comprehensively reviewed the literature and examined the available evidence for this association. Methods and Results After searching PubMed, EMBASE, and Cochrane Library databases, two investigators independently reviewed 3117 studies published through May 2021. Of these studies, 99 met the inclusion criteria (n = 108 patients). In patients with coexisting respiratory disease and TTS, the most common TTS symptom was dyspnea (70.48%), followed by chest pain (24.76%) and syncope (2.86%). The most common type of TTS was apical, accounting for 81.13% of cases, followed by the midventricular (8.49%), basal (8.49%), and biventricular (1.89%) types. Among the TTS cases, 39.82% were associated with obstructive lung disease and 38.89% were associated with pneumonia. Coronavirus disease 2019 (COVID-19), which has been increasingly reported in patients with TTS, was identified in 29 of 42 patients with pneumonia (69.05%). The overall mortality rate for patients admitted for respiratory disease complicated by TTS was 12.50%. Conclusion Obstructive lung disease and pneumonia are the most frequently identified respiratory triggers of TTS. Medications and invasive procedures utilized in managing respiratory diseases may also contribute to the development of TTS. Furthermore, the diagnosis of TTS triggered by these conditions can be challenging due to its atypical presentation. Future prospective studies are needed to establish appropriate guidelines for managing respiratory disease with concurrent TTS.

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“…Various environmental factors, such as CS, bacteria, or harmful particulates, can injure epithelial cells directly or indirectly. 25 The disruption of the structural integrity and dysfunction of the airway epithelium is related to the occurrence and development of COPD. For example, alterations of the epithelial barrier integrity can lead to increased bronchial mucus secretion and small airway fibrosis and obstruction, which ultimately result in ventilatory dysfunction and airway remodeling.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of cigarette smoke, Klebsiella pneumoniae, and their combination on airway epithelial barrier function in mice

Mei

et al. 2023

Environmental Toxicology

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Background: The airway epithelium acts as a physical barrier to protect pulmonary airways against pathogenic microorganisms and toxic substances, such as cigarette smoke (CS), bacteria, and viruses. The disruption of the structural integrity and dysfunction of the airway epithelium is related to the occurrence and progression of chronic obstructive pulmonary disease.Purpose: The aim of this study is to compare the effects of CS, Klebsiella pneumoniae (KP), and their combination on airway epithelial barrier function. Methods:The mice were exposed to CS, KP, and their combination from 1 to 8 weeks. After the cessation of CS and KP at Week 8, we observed the recovery of epithelial barrier function in mice for an additional 16 weeks. To compare the epithelial barrier function among different groups over time, the mice were sacrificed at Weeks 4, 8, 16, and 24 and then the lungs were harvested to detect the pulmonary pathology, inflammatory cytokines, and tight junction proteins. To determine the underlying mechanisms, the BEAS-2B cells were treated with an epidermal growth factor receptor (EGFR) inhibitor (AG1478). Results:The results of this study suggested that the decreased lung function, increased bronchial wall thickness (BWT), elevated inflammatory factors, and reduced tight junction protein levels were observed at Week 8 in CS-induced mice and these changes persisted until Week 16. In the KP group, increased BWT and elevated inflammatory factors were observed only at Week 8, whereas in the CS + KP group, decreased lung function, lung tissue injury, inflammatory cell infiltration, and epithelial

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The Relationship between Airway Inflammation and Exacerbation in Chronic Obstructive Pulmonary Disease

Cited by 20 publications

References 99 publications

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Takotsubo syndrome and respiratory diseases: a systematic review

Comparative study of cigarette smoke, Klebsiella pneumoniae, and their combination on airway epithelial barrier function in mice

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