The relationship between age-related hearing loss and synaptic changes in the hippocampus of C57BL/6J mice

Effect of perinatally supplemented flavonoids on brain structure, circulation, cognition, and metabolism in C57BL/6J mice

“…An explanation might be that the habituation response is decreased due to hearing loss. C57BL/6J mice are prone to early onset hearing loss, but not starting at such an early age (Johnson et al, 1997;Yu et al, 2011). This makes it unlikely that hearing loss caused the absence of the habituation effect.…”

Clinical observation on hearing conditions of centenarians in northern district of China

“…It has been revealed that presbycusis is caused by degeneration of both the peripheral and the central auditory systems [14][15][16], of which the role of the central auditory system is more important [17,18]. The speech discrimination ability of the elderly is severely affected by degeneration of the cortical center, presenting with disproportionate decline of speech discrimination rate and pure-tone hearing thresholds [16].…”

“…16.0 (SPSS Inc., Chicago, IL, USA) was used for all statistical analysis. Centenarians and control groups were compared using Student's t test and Kruskal-Wallis test.…”

Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus

“…On the contrary, there is evidence that hearing loss causes degeneration in the hippocampus. Age-related increase of hearing thresholds in C57BL/6J mice was accompanied by synaptic degeneration in the hippocampus as well as decreased learning performance in the Morris water maze (Yu et al, 2011). Moreover, reversible conductive hearing loss in rats resulted in depression and memory deficits along with a decrease of dopamine and homovanillic acid content and of choline-acetyltransferase and acetylcholinesterase activity.…”