The relationship between adiposity and stature in prepubertal children with celiac disease

Nwosu, Benjamin Udoka; Snook, Rachel I.; Maranda, Louise

doi:10.1515/jpem-2012-0312

Cited by 4 publications

(2 citation statements)

References 32 publications

(36 reference statements)

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“…Sin embargo, la presencia de obesidad no solo se ha observado en pacientes celiacos que están en tratamiento con DLG, sino también en aquellos que están con reciente diagnóstico 13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31 . La prevalencia de obesidad en distintas poblaciones celiacas al momento del diagnóstico y sin DLG varía de 0 a un 11,5% y cuando se evalúa malnutrición por exceso (sobrepeso y distintos grados de obesidad), este valor aumenta a un 44% (Tabla 1).…”

Section: Sobrepeso Y Obesidad En Pacientesunclassified

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Sobrepeso y obesidad en la enfermedad celiaca activa: posibles mecanismos fisiopatológicos

2019

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La enfermedad celiaca (EC) es una enteropatía crónica del intestino delgado, mediado por una respuesta inmune, gatillada por la exposición al gluten en individuos genéticamente susceptibles. La presentación clínica de la EC es variada y conduce a mala absorción. El estado nutricional en el momento del diagnóstico de la EC depende del tiempo en que la enfermedad ha estado activa, la extensión de la inflamación intestinal, grado de mala absorción e ingesta alimentaria. Sin embargo, en los últimos años se ha observado un cambio epidemiológico del estado nutricional en los pacientes celiacos al momento del diagnóstico. La presente revisión tuvo por objetivo realizar un análisis descriptivo de la presencia de obesidad en pacientes celiacos y de los posibles mecanismos fisiopatológicos que la explicarían.

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Section: Sobrepeso Y Obesidad En Pacientesunclassified

“…Van der Pals M. 2014 (20) 239 niños Suecia 4,2 82 13,8* Brambilla P. 2013 (21) 150 niños Italia 28,4 65,3 6,3* Nwosu BU. 2013 (22) 40 niños EE.UU.…”

Section: Autor N/grupo Población Estado Nutricional Etariounclassified

Sobrepeso y obesidad en la enfermedad celiaca activa: posibles mecanismos fisiopatológicos

2019

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Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis

et al. 2022

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Context Obesity is a significant risk factor for many pathological conditions. Whether a gluten-free diet (GFD) is a risk factor for overweight or obesity remains controversial. Objective The primary aim of this study was to assess the prevalence of body mass index (BMI) categories at disease presentation and the variation in BMI category from underweight/normal to overweight/obese and vice versa during a GFD. Data Sources PubMed, Scopus, and Web of Science databases were searched through February 2021 for retrospective, cross-sectional, and prospective studies reporting BMI categories at disease diagnosis and during a GFD. Data Extraction Data were extracted by 2 reviewers independently. Disagreements were resolved by consensus; a third reviewer was consulted, if necessary. Risk of bias was assessed with the Cochrane ROBINS-I tool. Data Analysis Subgroup analysis based on age (pediatric/adult patients), study design (prospective, cross-sectional, retrospective), and duration of GFD was performed.. Forty-five studies were selected (7959 patients with celiac disease and 20 524 healthy controls). The mean BMI of celiac patients at presentation was significantly lower than that of controls (P < 0.001). During a GFD, the mean BMI increased significantly (mean difference = 1.14 kg/m2 [95%CI, 0.68–1.60 kg/m2]; I2 = 82.8%; P < 0.001), but only 9% of patients (95%CI, 7%–12%; I2 = 80.0%) changed from the underweight/normal BMI category to the overweight/obese category, while 20% (95%CI, 11%–29%; I2 = 85.8%) moved into a lower BMI category. Conclusion Most celiac patients had a normal BMI at presentation, although the mean BMI was significantly lower than that of controls. A GFD does not increase the risk of becoming overweight/obese, especially in children. The quality of several studies was suboptimal, with moderate or high overall risk of bias and heterogeneity.

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Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children

et al. 2013

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BackgroundThe health consequences of lactose intolerance (LI) are unclear.AimsTo investigate the effects of LI on stature and vitamin D status.HypothesesLI subjects will have similar heights and vitamin D status as controls.Subjects and MethodsPrepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume <3cc; girls: Tanner 1 breasts), diagnosis of LI by hydrogen breath test, and no history of calcium or vitamin D supplementation. Vitamin D deficiency was defined as 25-hydroxyvitamin D [25(OH)D] <50 nmol/L. Gender-adjusted midparental target height (MPTH) z-score was calculated using NCHS data for 18 year-old adults. Data were expressed as mean ± SD.ResultsThere was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into normal weight (BMI <85th percentile) vs. overweight/obese (BMI ≥85th percentile), the normal weight controls had significantly higher 25(OH)D level than both the normal weight LI children (78.3 ± 32.6 vs. 62.9 ± 23.2, p = 0.025), and the overweight/obese LI children (78.3±32.6 vs. 55.3±16.5, p = 0.004). Secondly, there was no overall difference in height z-score between the LI children and controls. The normal weight LI patients had similar height as normal controls (-0.46 ± 0.89 vs. -0.71 ± 1.67, p = 0.53), while the overweight/obese LI group was taller than the normal weight controls (0.36 ± 1.41 vs. -0.71 ± 1.67, p = 0.049), and of similar height as the overweight/obese controls (0.36 ± 1.41 vs. 0.87 ± 1.45, p = 0.28). MPTH z-score was similar between the groups.ConclusionShort stature and vitamin D deficiency are not features of LI in prepubertal children.

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The relationship between adiposity and stature in prepubertal children with celiac disease

Abstract: Overweight/obese prepubertal children with CD were taller than both their normal-weight CD peers and the normal-weight controls, but were of similar height as the overweight/obese control subjects.

Cited by 4 publications

References 32 publications

Sobrepeso y obesidad en la enfermedad celiaca activa: posibles mecanismos fisiopatológicos

Sobrepeso y obesidad en la enfermedad celiaca activa: posibles mecanismos fisiopatológicos

Risk of obesity during a gluten-free diet in pediatric and adult patients with celiac disease: a systematic review with meta-analysis

Lactose Intolerance: Lack of Evidence for Short Stature or Vitamin D Deficiency in Prepubertal Children

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