The relationship between adiponectin, NT-pro-BNP and left ventricular ejection fraction in non-cachectic patients with systolic heart failure: an observational study

Abstract

Objective: NT-pro-brain natriuretic peptide (NT-proBNP) has been shown to be an accurate diagnostic marker in patients with heart failure (HF). Adiponectin (Adp) levels are increased in HF but its diagnostic value is still uncertain in these patients. The study was designed to investigate the possible association of these markers in non-cachectic patients with newly diagnosed systolic heart failure. Methods: Fifty-seven systolic HF patients and 20 matched controls were enrolled in an observational cross-sectional study. Physical and echocardiographic examinations were performed and serum Adp, NT-proBNP, tumor necrosis factor-alpha (TNF-α) levels were measured. Study variables were compared between the groups. Correlation analyses were done and the diagnostic validity of the markers was compared with ROC analysis. Results: Adp and NT-proBNP levels were significantly higher in HF group (20.19±12.9 vs. 7.65±4.6 μg/mL; p<0.001 and 1051.74±606.2 vs. 222.53±65.6 pg/mL; p=0.002; respectively). TNF-α levels were similar between the groups (2.83±1.8 vs. 2.08±1.2 pg/mL; p=0.582). Correlation analysis showed significant association among Adp and NT-proBNP levels, (r=0.448; p<0.001), and left ventricular ejection fraction (LVEF) values (r=-0.466; p<0.001). The Adp and NT-proBNP showed comparable diagnostic performances with mean [95% confidence interval] areas under the curves of 0.857 (0.771-0.944) and 0.888 (0.815-0.960), respectively. Conclusion: There were significant correlation between Adp levels with NT-proBNP levels and LVEF values but no any association between Adp levels with body mass index values and TNF-α levels in patients with newly diagnosed systolic heart failure. The result may arouse suspicion about the hypothesis, which proposes that Adp levels simply reflects disease severity or cardiac cachexia in patients with HF. (Anadolu Kardiyol Derg 2013; 13: 221-6)

Associations of adiponectin and leptin with brain natriuretic peptide in African Americans: the Jackson Heart Study

“…The direct association of adiponectin and BNP has been consistently reported in observational studies [28,29]. Cross-sectional analyses have reported positive correlations of adiponectin and BNP in noncachectic patients with systolic heart failure [30]. Increased levels of adiponectin were associated with elevated BNP levels and LVH in hemodialysis patients with type 2 diabetes mellitus [31].…”

Relationship between Adipokines and Cardiovascular Ultrasound Parameters in Metabolic-Dysfunction-Associated Fatty Liver Disease

“…Moreover, although LVEF was not significantly associated with adiponectin in the univariate analysis, interestingly, we found a significant inversely proportional association after conducting the multivariate regression analysis. Similarly, several published studies reported a significant inverse correlation between adiponectin and LVEF, where adiponectin levels increase significantly as LVEF worsens [ 54 , 55 ]. Although adiponectin levels are not predictive of the development of heart failure in humans, several human studies demonstrated that increased circulating adiponectin levels were linked to increased mortality in patients with chronic heart failure with reduced ejection fraction (HFrEF) [ 56 , 57 , 58 , 59 , 60 ].…”

Neutrophil to lymphocyte ratio predicts poor functional capacity in patients with heart failure

“…[16][17][18][19] Previous studies have demonstrated the lack of a relationship between exercise capacity and conventional echocardiographic parameters such as LV function, and LV diameter. [20][21][22][23][24][25] Similarly, we found that FC was poorly correlated with echocardiographic parameters. In contrast, a strong correlation was found between N/L ratio and FC; moreover, N/L ratio was identified as an independent determinant of exercise capacity.…”