The relationship between 99mTc-HMPAO brain SPECT and the scores of real life rating scale in autistic children

Regional cerebral blood flow in childhood autism: a SPET study with SPM evaluation

“…Many areas showed a statistically significant reduction of cerebral perfusion, especially the temporo-parietal, frontal and occipital regions as reported in Table 1, in concordance with previous studies [13,16,17,24,27,28,30]. Figures 3 and 4 show the statistical parametric map (SPM) evaluations in the standard format viewed from the right, the back and the top of the brain and these anatomical spaces correspond to the atlas proposed by Talairach and Tournox [31].…”

“…In recent years, an approach based on tomographic methods to study the cerebral blood flow ( 133 Xe, 99m Tc-HMPAO and 99m Tc-ECD), metabolism with PET ( 18 F-FDG) and functional changes with MRI has been introduced [16][17][18][19][20][21][22][23][24][25][26][27][28]. The aim of our study was to establish a relationship between regional cerebral blood flow assessed with 0143-3636 c 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins 99m Tc-ECD SPET and the clinical manifestation and progression of autistic disease, comparing the results with those obtained in a control group of normal children.…”

Reduced effect of stimulation of AMPA receptors on cerebral O2 consumption in a rat model of autism

“…Most investigators have assumed that ASD is associated with reduced cerebral function, metabolism and blood flow and there are studies that have reported such decrements in several brain regions (Haznedar et al, 2006). However, others have reported little or no change in cerebral metabolism or blood flow (Kaya et al, 2002). Interestingly, as early as 1985, it was reported that cerebral glucose utilization was elevated in autism (Rumsey et al, 1985).…”

Hyperbaric oxygen therapy may improve symptoms in autistic children

“…Multiple independent single photon emission computed tomography (SPECT) and positron emission tomography (PET) research studies have demonstrated hypoperfusion to several areas of the autistic brain, most notably the temporal lobes [26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Several studies show that reduced blood flow to the temporal regions and other brain areas correlates with many of the clinical findings associated with autism including repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication, sensory perception, and social interaction [27,29,31,[39][40][41][42].…”