The Relationship Between 6 Polymorphisms of Caveolin-1 Gene and the Risk of Breast Cancer

Fard, Zahra Tahmasebi; Nafisi, Nahid

doi:10.1016/j.clbc.2018.01.005

Cited by 8 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A part of the breast tissue subjected to surgery was placed in karyotype by a pathologist to be stored at -80°C, and after collecting all the samples, their DNA was extracted. The DNA of the samples was extracted by the salting-out method (13), and its quality and quantity were evaluated with agarose gel and Nano Drop. All extracted DNAs were then amplified with specific primers of the beta-globin gene that designed it (Forward: 5'-GAAGAGCCAAGGACAGGTAC-3' & Reverse: 5'-CAACTTCATCCACGTTCACC-3') and SYBR Green-based real-time PCR.…”

Section: Dna Extraction and Real-time Pcrmentioning

confidence: 99%

Molecular Detection of Human Cytomegalovirus in Breast Cancer of Iranian Women Using Real-time PCR

2021

View full text Add to dashboard Cite

Background: The role of carcinogenic viruses in developing breast cancer has not yet been identified. Many studies have examined the association between breast cancer and human cytomegalovirus (HCMV), but conflicting results have been reported. Objectives: The aim of this study was to evaluate the levels of IgM & IgG antibodies against HCMV by identifying the viral genome in the breast tissue of women with breast cancer. Methods: A total of 60 patients with breast cancer and 60 healthy individuals (40 cases with fibroadenoma and 20 healthy samples) were selected. Serum levels of IgM & IgG antibodies against HCMV were measured by ELISA, and after DNA extraction from the breast tissue, the presence of the cytomegaloviruses (CMV) genome was assessed by Real-Time PCR. Results: Real-time PCR results showed that 20 samples of breast cancer tissue and 5 samples of fibroadenoma were positive for CMV genome (P = 0.001, OR: 5.50, CI 95%: 1.90 - 15.89). All samples had CMV-IgG antibody in their serum, but their mean serum level was higher in the cancer group (48.27 ± 15.99 U/mL) than the control group (40.11 ± 18.01 U/mL) (P = 0.004). However, CMV-IgM anti-viral antibody was positive in 5 cases with cancer and 3 cases in the control group. The mean serum concentration of this antibody was higher in the cancer group (6.60 ± 6.75 U/mL) than the control group (4.92 ± 3.03 U/mL) (P = 0.099). Conclusions: Increased serum levels of anti-CMV antibodies in patients with cancer, as well as the presence of viral genomes in some cases, indicate the carcinogenesis effect of the virus.

show abstract

Section: Dna Extraction and Real-time Pcrmentioning

confidence: 99%

Molecular Detection of Human Cytomegalovirus in Breast Cancer of Iranian Women Using Real-time PCR

2021

View full text Add to dashboard Cite

show abstract

“…Cav1 is the main component of caveolae, and it participates in various biological events. It has been reported that genetic changes of Cav1 might modify the risk for breast cancer,151 and Cav1 acts both as a tumor suppressor as well as an oncogene, and plays a key role in breast cancer tumorigenesis 152. In addition to breast cancer carcinogenic process, Cav1 is also associated with lung cancer,153,154 colorectal cancer,155 gastric cancer,156,157 cervical cancer,158 hepatocellular carcinoma,159 pancreatic cancer,160 bladder cancer,161 pulmonary hypertension,162–164 virus infection,165,166 cardiovascular disease,167,168 diabetes mellitus,169 nanomedicines endocytosis170 and lipodystrophy 171.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

<p>Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment</p>

Qian

Pan

Huang

et al. 2019

OTT

View full text Add to dashboard Cite

Human breast cancer is one of the most frequent cancer diseases and causes of death among female population worldwide. It appears at a high incidence and has a high malignancy, mortality, recurrence rate and poor prognosis. Caveolin-1 (Cav1) is the main component of caveolae and participates in various biological events. More and more experimental studies have shown that Cav1 plays a critical role in the progression of breast cancer including cell proliferation, apoptosis, autophagy, invasion, migration and breast cancer metastasis. Besides, Cav1 has been found to be involved in chemotherapeutics and radiotherapy resistance, which are still the principal problems encountered in clinical breast cancer treatment. In addition, stromal Cav1 may be a potential indicator for breast cancer patients' prognosis. In the current review, we cover the state-of-the-art study, development and progress on Cav1 and breast cancer, altogether describing the role of Cav1 in breast cancer progression and application in clinical treatment, in the hope of providing a basis for further research and promoting CAV1 gene as a potential target to diagnose and treat aggressive breast cancers.

show abstract

“…It has been reported that alteration of the Cav-1 gene may change the risk of breast cancer ( Fard and Nafisi, 2018 ). It has been reported that genetic changes in Cav-1 might modify the risk for breast cancer, and Cav-1 acts as both a tumor suppressor and an oncogene and plays a key role in breast cancer tumorigenesis ( Deb et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Role of Caveolae family-related proteins in the development of breast cancer

Han,

Qiu,

et al. 2023

Front. Mol. Biosci.

View full text Add to dashboard Cite

Breast cancer has become the most significant malignant tumor threatening women’s lives. Caveolae are concave pits formed by invagination of the plasma membrane that participate in many biological functions of the cell membrane, such as endocytosis, cell membrane assembly, and signal transduction. In recent years, Caveolae family-related proteins have been found to be closely related to the occurrence and development of breast cancer. The proteins associated with the Caveolae family-related include Caveolin (Cav) and Cavins. The Cav proteins include Cav-1, Cav-2 and Cav-3, among which Cav-1 has attracted the most attention as a tumor suppressor and promoting factor affecting the proliferation, apoptosis, migration, invasion and metastasis of breast cancer cells. Cav-2 also has dual functions of inhibiting and promoting cancer and can be expressed in combination with Cav-1 or play a regulatory role alone. Cav-3 has been less studied in breast cancer, and the loss of its expression can form an antitumor microenvironment. Cavins include Cavin-1, Cavin-2, Cavin-3 and Cavin-4. Cavin-1 inhibits Cav-1-induced cell membrane tubule formation, and its specific role in breast cancer remains controversial. Cavin-2 acts as a breast cancer suppressor, inhibiting breast cancer progression by blocking the transforming growth factor (TGF-β) signaling pathway. Cavin-3 plays an anticancer role in breast cancer, but its specific mechanism of action is still unclear. The relationship between Cavin-4 and breast cancer is unclear. In this paper, the role of Caveolae family-related proteins in the occurrence and development of breast cancer and their related mechanisms are discussed in detail to provide evidence supporting the further study of Caveolae family-related proteins as potential targets for the diagnosis and treatment of breast cancer.

show abstract

The Relationship Between 6 Polymorphisms of Caveolin-1 Gene and the Risk of Breast Cancer

Cited by 8 publications

References 22 publications

Molecular Detection of Human Cytomegalovirus in Breast Cancer of Iranian Women Using Real-time PCR

Molecular Detection of Human Cytomegalovirus in Breast Cancer of Iranian Women Using Real-time PCR

<p>Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment</p>

Role of Caveolae family-related proteins in the development of breast cancer

Contact Info

Product

Resources

About