The relationship between 25-hydroxyvitamin D levels and ambulatory arterial stiffness index in newly diagnosed and never-treated hypertensive patients

Ö, Malçok Gürel; Bilgiç, A; Demircelik, Bora; Özaydın, Mehmet; Bozduman, Fadime; Aytürk, Zübeyde; Yılmaz, Hikmet; Atar, Asli; Selçoki, Yusuf; Eryonucu, Beyhan

doi:10.1097/mbp.0000000000000157

Cited by 5 publications

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“…A negative relation between PWV and augmentation index and vitamin D was found in healthy adolescents [31], adolescents with diabetes mellitus [31] and children with chronic kidney disease [32]. Also, contrary to our results, Turkish authors [33] found a negative relation (r = -0.385, p < 0.001) between vitamin D status and AASI in adults with newly diagnosed hypertensive adults.…”

Section: Discussioncontrasting

confidence: 99%

Vitamin D in children with primary hypertension

Skrzypczyk

Ofiara

Szyszka

et al. 2018

Arterial Hypertension

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Introduction:Recent evidence suggests that vitamin D plays a role in pathogenesis of arterial hypertension. The aim was to assess vitamin D in children and adolescents with arterial hypertension. Material and methods: In 49 children (14.29 ± 3.17 years) with arterial hypertension we evaluated vitamin D status (according to Polish 2018 Guidelines), serum calcium, phosphorus, parathormone, alkaline phosphatase, office blood pressure, ABPM (including ambulatory arterial stiffness index [AASI]), BMI, GFR, uric acid, lipids and albuminuria. None of the children were supplemented with vitamin D. Results: Mean vitamin D concentration was 19.74 ± 9.68 ng/mL. Vitamin D severe deficiency (0-10 ng/mL) was found in 5 (10.2%), deficiency (> 10-20 ng/mL) in 29 (49.0%), suboptimal concentration (> 20-30 ng/mL) in 17 (34.7%), optimal concentration (> 30 to 50 ng/mL) in 1 (2.0%), and high concentration (> 50 to 100 ng/mL) in 2 (4.1%) children. Vitamin D was higher in spring-summer vs. autumn-winter (21.79 ± 10.19 vs. 15.53 ± 7.08 ng/mL, p = 0.03). Vitamin D correlated with height Z-score (r = 0.39, p < 0.01), BMI Z-score (r = -0.34, p = 0.02), uric acid (r = -0.31, p = 0.04), triglycerides (r = -0.37, p = 0.01), but not with office blood pressure and ABPM parameters except for heart rate (r = -0.38, p < 0.01). In 24 children treated with antihypertensive medications vitamin D correlated with AASI (r = 0.50, p = 0.04). Conclusions:1. Inadequate vitamin D supply is ubiquitous in children with arterial hypertension. 2. Vitamin D deficiency should be suspected especially in autumn-winter period and among obese and short children. 3. The relation between vitamin D status and ambulatory arterial stiffness index suggests negative influence of vitamin D on arterial wall but requires further investigations.

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Section: Discussioncontrasting

confidence: 99%

Vitamin D in children with primary hypertension

Skrzypczyk

Ofiara

Szyszka

et al. 2018

Arterial Hypertension

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“…Consistent with our findings, an observational study conducted among 544 healthy participants aged 20-79 years in the US showed an association between vitamin D insufficiency and increased arterial stiffness [50]. Similar findings regarding the association between 25(OH)D levels and arterial stiffness were also observed in two out of three smaller-scale observational studies conducted in Canadian, Turkish and Chinese populations (n=123-175) [51][52][53][54].…”

Section: Vitamin D and Pasisupporting

confidence: 90%

Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis

Sha,

Degen,

Vlaski

et al. 2024

Preprint

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Background: Potential calcium-related adverse events of vitamin D supplement use have not been addressed in large-scale, real-world data so far. Methods: Leveraging data from the UK Biobank, encompassing 445,493 individuals aged 40-69, we examined associations of high 25-hydroxyvitamin (25[OH]D) levels ≥100 nmol/L and vitamin D supplementation with hypercalcemia (plasma calcium >2.6 mmol/L), kidney stones, and atherosclerosis assessments (pulse wave arterial stiffness index and carotid intima-medial thickness). Regression models were comprehensively adjusted for 49 covariates. Results: Approximately 1.5% of the participants had high 25(OH)D levels, 4.3% regularly used vitamin D supplements, and 20.4% reported regular multivitamin use. At baseline, the hypercalcemia prevalence was 1.6%, and 1.1% were diagnosed with kidney stones during follow-up. High 25(OH)D levels were neither associated with calcium-related adverse events nor atherosclerosis assessments. Vitamin D and multivitamin supplementation were associated with an increased prevalence of hypercalcemia (odds ratios and 95% confidence intervals: 1.46[1.32-1.62] and 1.11[1.04-1.18], respectively) but were neither associated with atherosclerosis nor future kidney stones. Conclusion: High 25(OH)D levels observable in routine care were not associated with any adverse outcome. Vitamin D users have a slightly higher prevalence of hypercalcemia, possibly due to co-supplementation with calcium, but without higher atherosclerosis prevalence or risk of kidney stones.

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Vitamin D Deficiency and Cardiovascular Diseases: The Causality or Association?

Cheng

2018

International Journal of Gerontology

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The relationship between 25-hydroxyvitamin D levels and ambulatory arterial stiffness index in newly diagnosed and never-treated hypertensive patients

Abstract: Arterial stiffness measured by AASI in newly diagnosed and untreated patients with essential hypertension were significantly related to vitamin D levels.

Cited by 5 publications

References 0 publications

Vitamin D in children with primary hypertension

Vitamin D in children with primary hypertension

Safety Profile of Vitamin D Supplements Using Real-World Data from 445,493 Participants of the UK Biobank: Slightly Higher Hypercalcemia Prevalence but Neither Increased Risks of Kidney Stones nor Atherosclerosis

Vitamin D Deficiency and Cardiovascular Diseases: The Causality or Association?

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