The relations between vitamin D2 and D3 in the diet and plasma 250HD2 and 25OHD3 in elderly women in Great Britain

Newton, H. M. V.; Sheltawy, Marion J.; Hay, Alastair; Morgan, BarbaraG.E.

doi:10.1093/ajcn/41.4.760

Cited by 16 publications

(6 citation statements)

References 12 publications

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“…However, we had prospective information on vitamin D intake from foods and supplements in our cohort, and adjusting for these covariates did not alter our estimates substantially. While food frequency questionnaires, as used in the current study, have been shown to reflect plasma 25(OH)D levels reasonably well [r = 0.35; [18]], data of elderly people [19, 20] suggest that sun shine exposure is the most important determinant of total 25(OH)D level and therefore, in subjects with low sun exposure, total 25(OH)D level might constitute a better marker of dietary intake of vitamin D. It is therefore possible that, despite the fact that we were able to adjust for a number of important risk factors for osteoporosis including vitamin D intake, there may still be residual confounding for which we were unable to account.…”

Section: Discussionmentioning

confidence: 99%

Nightshift work and fracture risk: the Nurses’ Health Study

2008

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Summary-Night shift work suppresses melatonin production and has been associated with an increased risk of major diseases including hormonally related tumors. Experimental evidence suggests that light at night acts through endocrine disruption, likely mediated by melatonin. To date, no observational study has addressed the effect of night work on osteoporotic fractures, another condition highly sensitive to sex steroid exposure. Our study, to our knowledge the first to address this question, supports the hypothesis that night shift work may negatively affect bone health, adding to the growing list of ailments that have been associated with shift work.Introduction-We evaluated the association between night shift work and fractures at the hip and wrist in postmenopausal nurses.

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Section: Discussionmentioning

confidence: 99%

Nightshift work and fracture risk: the Nurses’ Health Study

2008

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“…The contribution of dietary vitamin D] is, however, thought to be of only marginal importance, approximately 10%. 10 The serum concentration of total I ,25(OH)2D showed no seasonal variation and the overall data was in agreement with the results of De Luca's' group where they studied adults aged 20-37 years The high individual variations of 1,25(OH)2D we have observed make it difficult to confer any real significance to its change in relation to serum 250HD] to the seasons or number of sunlight hours and suggest single measurements are inappropriate. However, it was interesting that the highest serum concentrations of 1,25(OH)2D observed were only in the winter/spring months and in the summer with the highest 250HD], 1,25(OH 2D) greater than 110 pmollL was not seen.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variation in Serum 25-Hydroxy Vitamin D₃ Does Not Affect 1,25-Dihydroxy Vitamin D

Hine

Roberts

1994

Ann Clin Biochem

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SUMMARY. The seasonal vanation of serum 25-hydroxy vitamin D 3 and 1,25-dihydroxy-vitamin D has been investigated. Blood was taken from 27 healthy volunteers, aged 21-44 years old at 3 monthly intervals over a period of 1 year. A scrolling monthly programme with 12 quarterly (3 month) time periods was developed. A summer associated increase in 25-hydroxy vitamin D 3 was significantly correlated with but lagged behind by 2 months, the increase in recorded sunlight hours. However, four individuals showed no seasonal rise but maintained constant concentrations throughout the year within the established reference range. Serum 1,25-dihydroxy vitamin D showed marked intra-individual variability with no seasonal pattern although the highest concentration (180 pmol/L) was observed in the winter and no concentration greater than 108 pmollL in the summer. Additional key phrases: scrolling 3-month analysis; sunlight assessmentIt is well established that there is a seasonal variation in the serum concentration of 25-hydroxy vitamin D 3 (250HD 3 ) associated with an increase after exposure to sunlight in the summer months and a decrease during the winter months.':" In contrast, there is no seasonal change in the serum concentration of 25-hydroxy vitamin D 2 as it is entirely dietary in origin.1 The effect of seasonal change on serum total 1,25-dihydroxy vitamin D (including D 2 and D 3 ) , the most physiologically active metabolite is less clear since studies using sequential sampling throughout the year the serum 1,25(OH)2D was shown to parallel the serum 250HD 3 concentration-while Chesney et al. I observed no seasonal variation at all.Routine measurement of these compounds is now much easier to carry out because of new improved commercial kits being available. It will be important, therefore, if changes in plasma concentrations of these compounds are to be linked with any pathological defined disease states that misinterpretation is not made because of a normal seasonal variation. The purpose of this investigation therefore was to establish the magnitude of the seasonal variation in the serum

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“…Unfortunately, a majority of the US population has vitamin D insufficiency with particular subgroups of the population at an even greater risk (e.g. the elderly and those with dark skin) even among otherwise healthy adults ( 7 , 8 ) . Moreover, considerable differences in 25(OH)D serum concentration exist between racial/ethnic groups in the USA, most strikingly between non-Hispanic whites and non-Hispanic blacks.…”

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confidence: 99%

Predicted vitamin D status and incidence of tooth loss and periodontitis

Jiménez

Giovannucci

Kaye

et al. 2013

Public Health Nutr.

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Objective Vitamin D insufficiency is highly prevalent, with particular subgroups at greater risk (e.g. the elderly and those with darker skin). Vitamin D insufficiency may partly explain US racial/ethnic disparities in the prevalence of periodontitis and tooth loss. We evaluated the association between a predictor score of plasma 25-hydroxyvitamin D (25(OH)D) and incidence of periodontitis and tooth loss. Design Detailed biennial questionnaires were collected on medical history, lifestyle practices and incident periodontitis and tooth loss. The predictor score was derived from variables known to influence circulating concentrations of plasma 25(OH)D and validated against plasma concentrations among a sub-sample. Multivariable Cox proportional-hazards models with time-varying covariates estimated the association between the predicted 25(OH)D score and time until first tooth loss. Subjects A total of 42 730 participants of the Health Professionals Follow-Up Study aged 40–75 years at baseline were followed from 1986 to 2006. Setting USA, representing all fifty states and the District of Columbia. Results We observed 13 581 incident tooth loss events from 539 335 person-years. There was a dose-dependent significant inverse association across quintiles of the predicted 25(OH)D score and incidence of tooth loss. In multivariable analyses, the highest quintile of the updated predicted 25(OH)D score compared with the lowest was associated with a 20 % lower incidence of tooth loss (hazard ratio 5 0·80, 95 % CI 0·76, 0·85; P value for trend <0·0 0 1); UV-B was also independently associated. Results for the predicted 25(OH)D score and periodontitis were similar. Conclusions These results are suggestive of an association between predictors of vitamin D and lower incidence of tooth loss and periodontitis.

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The relations between vitamin D2 and D3 in the diet and plasma 250HD2 and 25OHD3 in elderly women in Great Britain

Cited by 16 publications

References 12 publications

Nightshift work and fracture risk: the Nurses’ Health Study

Nightshift work and fracture risk: the Nurses’ Health Study

Seasonal Variation in Serum 25-Hydroxy Vitamin D₃ Does Not Affect 1,25-Dihydroxy Vitamin D

Predicted vitamin D status and incidence of tooth loss and periodontitis

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The relations between vitamin D2 and D3 in the diet and plasma 250HD2 and 25OHD3 in elderly women in Great Britain

Cited by 16 publications

References 12 publications

Nightshift work and fracture risk: the Nurses’ Health Study

Nightshift work and fracture risk: the Nurses’ Health Study

Seasonal Variation in Serum 25-Hydroxy Vitamin D3 Does Not Affect 1,25-Dihydroxy Vitamin D

Predicted vitamin D status and incidence of tooth loss and periodontitis

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Seasonal Variation in Serum 25-Hydroxy Vitamin D₃ Does Not Affect 1,25-Dihydroxy Vitamin D