The relations between scores on analogous scales from four personality questionnaires in 50 normal men

Curtin, François; Walker, Jean-Pierre; Badan, Maryse; Schulz, Pierre

doi:10.1016/0191-8869(95)00098-q

Cited by 21 publications

(12 citation statements)

References 10 publications

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“…50 Studies examining correlations of the HA and N scales with other self-report measures of trait anxiety also reveal a pattern of differential relationships. The N scale correlates highly 51 (r¼0.77) with Eysenck's Neuroticism scale; the HA scale correlates at a lower level 52 (r¼0.30), a finding in keeping with the fact that the item content of the Eysenck scale more closely parallels that of the facet scales of N than of HA. In summary, the differences in mean d values obtained for the two scales likely reflects the fact that the two scales measure the construct of trait anxiety in different ways-in brief, the two scales measure somewhat different constructs.…”

Section: Discussionsupporting

confidence: 58%

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

2004

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Studies of the association between polymorphisms of the serotonin transporter gene (5-HTT) and trait anxiety have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions under which the relationship holds. We conducted a meta-analysis of existing studies to provide formal statistical measures of the strength of the linked polymorphic region of the serotonin transporter gene (5-HTTLPR)-anxiety relationship. For the entire collection of 26 studies, results provided no support for a relationship between anxiety and the presence of the short form of the 5-HTTLPR polymorphism. There was strong evidence of the presence of moderating variables, however, and subsequent analysis revealed that choice of the measure of trait anxiety was significant. Studies using the Neuroticism scale of Costa and McCrae were found to produce a small positive effect (d¼0.23). Other potential moderators (country of study origin, type of subject) did not have a meaningful impact on d statistics. These findings indicate that 5-HTTLPR may in fact have a small but reliable influence on personality, particularly in the manifestation of trait anxiety when measured with a neuroticism scale based on the five-factor model of personality. Our results suggest that the success of future personality genetics research will be maximized by the use of personality measures from both the psychobiological and five-factor models.

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Section: Discussionsupporting

confidence: 58%

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

2004

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“…Two studies, [Jönsson et al, 1997[Jönsson et al, , 1998] however, use the monotony avoidance and impulsivity scales of the Karolinska Scales of Personality [Schalling et al, 1987] to measure NS. These scales have been shown to be significantly correlated with the novelty seeking scale [Curtin et al, 1995]. The range of d-values across samples and studies is obviously quite substantial (À0.89 to 0.62), and 11 of the d-values are negative in direction.…”

Section: Discussionmentioning

confidence: 97%

DRD4 and novelty seeking: Results of meta‐analyses

2002

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Studies of the association between polymorphisms within and near the dopamine D4 receptor (DRD4) gene and novelty seeking (NS) have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions under which the relationship holds. We conducted three meta-analyses of existing studies to provide formal statistical measures of the strength of the DRD4-NS relationship. Results provided no support for a relationship between NS and the presence of the 7-repeat allele of the VNTR polymorphism. A small positive effect, however, was found for long repeats of the same polymorphism. The most promising findings were obtained for the relationship with the -521 C/T promoter polymorphism, for which the analysis showed an effect size of 0.32. The positive findings are consistent with a polygenic model of influence on fundamental personality dimensions.

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“…Previous studies have shown that the variance shared by N and HA is between 26% and 55% (De Fruyt et al 2000). While Costa and McCrae’s N correlates highly with Eysenck’s N (0.77) (Aluja et al 2002), it correlates only modestly with Cloninger’s HA (0.30) (Curtin et al 1995), suggesting that measures of N may differ substantially from those of HA. Despite this, studies of the molecular genetic basis of anxiety-related traits have used both measures of N and HA almost equally.…”

Section: Introductionmentioning

confidence: 98%

5‐HTTLPR genotype and anxiety‐related personality traits: A meta‐analysis and new data

Munafò

Freimer²,

et al. 2008

American J of Med Genetics Pt B

243

153

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We investigated the strength of evidence for association of the 5-HTTLPR polymorphism and the personality trait of Harm Avoidance. We used new primary data from a large sample of adults drawn from the Finnish population. We also applied meta-analytic techniques to synthesize existing published data. The large number studies of the 5-HTTLPR polymorphism allowed us to apply a formal test of publication bias, as well as formally investigate the impact of potential moderating factors such as measurement instrument. Univariate ANOVA of primary data (n = 3,872), with 5-HTTLPR genotype as a between-groups factor, indicated no evidence of association with Harm Avoidance (p = 0.99). Meta-analysis indicated no evidence of significant association of 5-HTTLPR with Harm Avoidance (d = 0.02, p = 0.37), or EPQ Neuroticism (d = 0.01, p = 0.71), although there was evidence of association with NEO Neuroticism (d = 0.18, p < 0.001). Our analyses indicate that the 5-HTTLPR variant is not associated with Harm Avoidance. Together with our previous analyses of a large sample of participants with extreme Neuroticism scores (defined by the EPQ), we have data that excludes a meaningful genetic effect of the 5-HTTLPR on two measures of anxiety-related personality traits. There remains the possibility that the variant influences the NEO personality questionnaire measure of Neuroticism. However, a large, well-powered primary study is required to test this hypothesis directly and adequately.

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The relations between scores on analogous scales from four personality questionnaires in 50 normal men

Cited by 21 publications

References 10 publications

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety

DRD4 and novelty seeking: Results of meta‐analyses

5‐HTTLPR genotype and anxiety‐related personality traits: A meta‐analysis and new data

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